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Basic Research Single Topic Conference 
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The Henry M. and Lillian Stratton
Basic Research Single Topic Conference

Mitochondria and Hepatotoxicity
Friday June 8 - Saturday June 9, 2012
Emory Conference Center Hotel – Atlanta, GA

Course Directors: Neil Kaplowitz, MD, Hartmut W. Jaeschke, PhD and John J. Lemasters, MD, PhD

Description
This Single Topic Conference will bring together 150-250 scientists working on the basic and clinical aspects of hepatotoxicity. The focus of the meeting will be on how mitochondrial dysfunction in the context of other cellular and subcellular events contributes to hepatic pathobiology leading to apoptotic and necrotic cell death. The mechanistic actions of a wide variety of toxicants will be considered, ranging from acetaminophen to antivirals to fatty liver disease. Recent developments in the field will be emphasized. Attendees will include both basic and clinical investigators. Junior investigators and pre- and post-doctoral trainees will be encouraged to attend.

Goals and Objectives:

  • New approaches to assess and screen mitochondrial function in vivo and in vitro
  • Types of mitochondrial dysfunction that can contribute to toxicity
  • Relation of mitochondrial dysfunction to other cellular events, such as protein kinase cascades, oxidative stress, signal transduction, etc.
  • Generation of interest by junior investigators in hepatic pathophysiology

Call for Abstracts
We are no longer accepting abstract submissions.

* Continuing Medical Education credits will not be provided at this conference.

Support of this conference by the Henry M. and Lillian Stratton Estate is gratefully acknowledged.

 

 Registration

 Clinical Research STC

Continue learning about acetaminophen poisoning. Register for both the Basic and Clinical STCs and save $100.

 Important Documents

Fact Sheet [PDF]

 Conference Center Housing

Reserve your room at the Emory Conference Center Hotel online or call 800-933-6679. Use "AASLD" for the group code.

 ‭(Hidden)‬ Custom List View Classes

 Friday, June 8, 2012

SessionFilterPresenterFilter
7:00 am
Breakfast
8:00 am
Welcome and Overview
Neil Kaplowitz, MD, Hartmut W. Jaeschke, PhD and
John J. Lemasters, MD, PhD
Session I: Mitochondrial Biogenesis and Turnover
Moderator: Neil Kaplowitz, MD
8:10 am
Introduction to Mitochondria and Bioenergetics
Dean P. Jones, PhD
8:30 am
Discussion
8:40 am
Mitochondrial Biogenesis in Response to Oxidative Stress
Rick G. Schnellman, PhD
9:00 am
Discussion
9:10 am
Molecular Basis of Mitochondrial Behaviors

Jodi Nunnari, PhD

9:30 am
Discussion
9:40 am
Mitochondria Quality Control in Oxidative Stress
Xiao-Ming Yin, MD, PhD
10:00 am
Discussion
10:10 am
Break
Session II: Mitochondria in Cell Death – Outer Membrane
Moderator: Xiao-Ming Yin, MD, PhD
10:40 am
Death Receptors Signaling in Models of Liver Disease: From Membrane to Cell Death
Christian Trautwein, MD
11:00 am
Discussion
11:10 am
The Role of Mitochondrial Apoptosis Channel MAC in Apoptosis
Kathleen W. Kinnally, PhD
11:30 am
Discussion
11:40 am
ER Protein Misfolding and Mitochondrial Oxidative Stress Cause Apoptosis
Randal J. Kaufman, PhD
Noon
Discussion
12:10 pm
Lunch
Session III: Mitochondria in Cell Death – Inner Membrane, Matrix and Beyond
Moderator: Christian Trautwein, MD
1:10 pm
Iron Translocation from Lysosomes to Mitochondria in Oxidative Stress-Induced Injury
John J. Lemasters, MD, PhD
1:30 pm
Discussion
1:40 pm
Regulation of Programmed Necrosis
Alexei Degterev, PhD
2:00 pm
Discussion
2:00 pm
Lipotoxicity: Free Fatty Acid-induced Apoptosis in Nonalcoholic Fatty Liver Disease
Harmeet Malhi, MBBS
2:30 pm
Discussion
2:40 am
Mitochondria, Calcium, and Apoptosis
Michael H. Nathanson, MD, PhD
3:00 pm
Discussion
3:10 pm
Abstract Oral Session
5:00 pm
Poster Session
7:00 pm
Dinner

 Saturday, June 9, 2012

SessionFilterPresenterFilter
7:00 - 8:00 am
Breakfast
Session IV: Alcoholic and Non-Alcoholic Steatohepatitis
Moderator: John J. Lemasters, MD, PhD
8:00 am
Mitochondrial Toxicity in Alcoholic and Non-Alcoholic Liver Disease
José C. Fernández-Checa, PhD
8:20 am
Discussion
8:30 am
Role of Autophagy in Ethanol-Induced Hepatotoxicity and Steatosis
Wen-Xing Ding, MD, PhD
8:50 am
Discussion
9:00 am
Intravital Imaging of Mitochondrial Uncoupling During the Evolution of Ethanol-induced Steatosis
Zhi Zhong, MD, PhD
9:20 am
Discussion
9:30 am
Mitochondrial Proteomics in ASH and NASH
Shannon M. Bailey, PhD
9:50 am
Discussion
10:00 am
Abstract Oral Session
10:40 am
Break
Session V: Drugs and Viruses
Moderator: Hartmut W. Jaeschke, PhD
11:00 am
Hepatitis C and Mitochondria
Steven A. Weinman, MD, PhD
11:20 am
Discussion
11:30 am
Mitochondrial Dysfunction in Drug-Induced Steatosis and Steatohepatitis
Bernard Fromenty, PhD
11:50 am
Discussion/Closing Remarks
Noon
Lunch
Session IA: Mitochondrial Toxicity in Acetaminophen Poisoning (Joint Session with the Clinical Research Conference)
Moderator: Paul B. Watkins, MD and John J. Lemasters, MD, PhD
1:10 pm
Mitochondrial Reactive Oxygen and Nitrogen Species in Acetaminophen Hepatotoxicity
Jack A. Hinson, PhD
1:30 pm
Discussion
1:40 pm
Signal Transduction in Hepatotoxicity
Neil Kaplowitz, MD
2:00 pm
Discussion
2:10 pm
The Role of Mitochondria in Injury and Repair from Acetaminophen Poisoning
Hartmut W. Jaeschke, MD
2:30 pm
Discussion
2:40 pm
Break