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Single Topic Conferences
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Basic Research Single Topic Conference
The Henry M. and Lillian Stratton Basic Research Single Topic Conference Mitochondria and Hepatotoxicity Friday June 8 - Saturday June 9, 2012 Emory Conference Center Hotel – Atlanta, GA
Course Directors: Neil Kaplowitz, MD, Hartmut W. Jaeschke, PhD and John J. Lemasters, MD, PhD
Description This Single Topic Conference will bring together 150-250 scientists working on the basic and clinical aspects of hepatotoxicity. The focus of the meeting will be on how mitochondrial dysfunction in the context of other cellular and subcellular events contributes to hepatic pathobiology leading to apoptotic and necrotic cell death. The mechanistic actions of a wide variety of toxicants will be considered, ranging from acetaminophen to antivirals to fatty liver disease. Recent developments in the field will be emphasized. Attendees will include both basic and clinical investigators. Junior investigators and pre- and post-doctoral trainees will be encouraged to attend.
Goals and Objectives:
- New approaches to assess and screen mitochondrial function in vivo and in vitro
- Types of mitochondrial dysfunction that can contribute to toxicity
- Relation of mitochondrial dysfunction to other cellular events, such as protein kinase cascades, oxidative stress, signal transduction, etc.
- Generation of interest by junior investigators in hepatic pathophysiology
Call for Abstracts We are no longer accepting abstract submissions.
* Continuing Medical Education credits will not be provided at this conference.
Support of this conference by the Henry M. and Lillian Stratton Estate is gratefully acknowledged.
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| 7:00 am | | | | 8:00 am | | Neil Kaplowitz, MD, Hartmut W. Jaeschke, PhD and John J. Lemasters, MD, PhD | |
Session I: Mitochondrial Biogenesis and Turnover | Moderator: Neil Kaplowitz, MD | | 8:10 am |
Introduction to Mitochondria and Bioenergetics | | | 8:30 am | | | | 8:40 am | Mitochondrial Biogenesis in Response to Oxidative Stress | | | 9:00 am | | | | 9:10 am |
Molecular Basis of Mitochondrial Behaviors | | | 9:30 am | | | | 9:40 am |
Mitochondria Quality Control in Oxidative Stress | | | 10:00 am | | | | 10:10 am | | | |
Session II: Mitochondria in Cell Death – Outer Membrane | Moderator: Xiao-Ming Yin, MD, PhD | | 10:40 am |
Death Receptors Signaling in Models of Liver Disease: From Membrane to Cell Death | | | 11:00 am | | | | 11:10 am |
The Role of Mitochondrial Apoptosis Channel MAC in Apoptosis | Kathleen W. Kinnally, PhD | | 11:30 am | | | | 11:40 am |
ER Protein Misfolding and Mitochondrial Oxidative Stress Cause Apoptosis | | | Noon | | | | 12:10 pm | | | |
Session III: Mitochondria in Cell Death – Inner Membrane, Matrix and Beyond | Moderator: Christian Trautwein, MD | | 1:10 pm | Iron Translocation from Lysosomes to Mitochondria in Oxidative Stress-Induced Injury | John J. Lemasters, MD, PhD | | 1:30 pm | | | | 1:40 pm |
Regulation of Programmed Necrosis | | | 2:00 pm | | | | 2:00 pm |
Lipotoxicity: Free Fatty Acid-induced Apoptosis in Nonalcoholic Fatty Liver Disease | | | 2:30 pm | | | | 2:40 am |
Mitochondria, Calcium, and Apoptosis | Michael H. Nathanson, MD, PhD | | 3:00 pm | | | | 3:10 pm | | | | 5:00 pm | | | | 7:00 pm | | |
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| 7:00 - 8:00 am | | | | Session IV: Alcoholic and Non-Alcoholic Steatohepatitis | Moderator: John J. Lemasters, MD, PhD | | 8:00 am | Mitochondrial Toxicity in Alcoholic and Non-Alcoholic Liver Disease | José C. Fernández-Checa, PhD | | 8:20 am | | | | 8:30 am | Role of Autophagy in Ethanol-Induced Hepatotoxicity and Steatosis | | | 8:50 am | | | | 9:00 am |
Intravital Imaging of Mitochondrial Uncoupling During the Evolution of Ethanol-induced Steatosis | | | 9:20 am | | | | 9:30 am | Mitochondrial Proteomics in ASH and NASH | | | 9:50 am | | | | 10:00 am | | | | 10:40 am | | | |
Session V: Drugs and Viruses | Moderator: Hartmut W. Jaeschke, PhD | | 11:00 am | Hepatitis C and Mitochondria | Steven A. Weinman, MD, PhD | | 11:20 am | | | | 11:30 am |
Mitochondrial Dysfunction in Drug-Induced Steatosis and Steatohepatitis | | | 11:50 am | Discussion/Closing Remarks | | | Noon | | | |
Session IA: Mitochondrial Toxicity in Acetaminophen Poisoning (Joint Session with the Clinical Research Conference) | Moderator: Paul B. Watkins, MD and John J. Lemasters, MD, PhD | | 1:10 pm |
Mitochondrial Reactive Oxygen and Nitrogen Species in Acetaminophen Hepatotoxicity | | | 1:30 pm | | | | 1:40 pm | Signal Transduction in Hepatotoxicity | | | 2:00 pm | | | | 2:10 pm | The Role of Mitochondria in Injury and Repair from Acetaminophen Poisoning | | | 2:30 pm | | | | 2:40 pm | | |
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