The Henry M. and Lillian Stratton Basic Research Single Topic Conference:Pattern Recognition Receptors and Innate Immune Signaling Pathways in Liver Diseases
September 12-14, 2009
Emory Conference Center Hotel, Atlanta, Georgia
Course Directors: David A. Brenner, MD; Stanley M. Lemon, MD;
Gyongyi Szabo, MD, PhD
Fact Sheet
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Travel Awards:
A limited number of travel awards will be available for trainees whose abstract submission has been accepted.
Course Description
This conference will provide a state-of-the-art update on the role of pattern recognition receptors (PRR) and their signaling pathways in the broad spectrum of liver diseases. The role of toll-like receptors (TLRs) and helicases will be discussed with particular interest in the utilization of the different intracellular adapter molecules and signaling pathways as they relate to different types of liver diseases. The role of pattern recognitions receptors will be reviewed in viral, alcoholic, and non-alcoholic hepatitis as well as in autoimmune disease, liver regeneration, and transplantation. TH interaction between TLR-mediated inflammatory pathways and cancer will be discussed.
Goals and Objectives:
• Provide up-to-date information on the role of toll-like receptors and related pattern recognition receptors in relation to the pathophysiology of liver diseases.
• Highlight new and expanding areas of research and foster collaboration between hepatology researchers, clinical investigators, and experts in the field of pattern recognition receptors.
• Raise knowledge and awareness about pattern recognition receptors, their signaling pathways, and the role of innate immune system in various liver diseases that may provide a target for future therapeutic interventions.
Who Should Attend:
Scientists and clinicians interested in basic and translational research in liver diseases and hepatitis.
Note:* All presentations will be twenty minutes followed by ten minute discussions.
Saturday, September 12, 2009
5:00-5:10pm Opening Remarks
Session 1: Toll-like Receptors - The Unfolding Mysteries
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5:10-5:40pm
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Toll-like Receptors – Endotoxin and Beyond
Bruce Beutler, MD
Scripps Research Institute |
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5:40-6:10pm
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TLRs: Linking Inflammation to Diseases
Douglas Golenbock, MD
University of Massachusetts Medical School |
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6:10-6:40pm
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IKKi and IRF3 Signaling
Kate Fitzgerald, MD
University of Massachusetts Medical School |
| 6:40-6:50pm |
Day 1 Wrap-up |
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Sunday, September 13, 2009
8:00-8:10am Opening Remarks
Session 2: Pattern Recognition Receptors in Viral Hepatitis
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8:10-8:40am
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TLR3-Mediated Control of HCV Infection
Kui Li, PhD
University of Tennessee-Memphis |
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8:40-9:10am
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Pattern Recognition in Viral Hepatitis Infections
Michael Gale Jr., PhD
University of Washington |
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9:10-9:40am
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Viral Evasion of Innate Immune Signaling Pathways
Stanley Lemon, MD
The University of Texas Medical Branch at Galveston |
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9:40-10:10am
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Induction and Inhibition of Interferon Effector Functions by HCV
Frank Chisari, MD
The Scripps Research Institute |
| 10:10-10:40am |
Break |
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10:40-11:10am
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TLR-Mediated Signals in Liver Cell Cross-Talk
Nicholas Crispe, MD
Seattle Biomedical Research Institute |
Session 3: TLRs, Endogenous Ligands and Autoimmunity
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11:10-11:40am
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Inflammasome and Sensing the Enemy Within
Kenneth L. Rock, MD
University Massachusetts Medical School |
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11:40-12:10pm
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TLRs and Inflammasome in APAP Injury
Waj Mehal, MD
Yale University |
| 12:10pm-1:10pm |
Lunch |
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1:10-1:40pm
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TLRs and Sterile Inflammation in Ischemia Liver Injury
Timothy Billiar, MD
University of Pittsburgh |
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1:40-2:10pm
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TLR9 in Primary Biliary Cirrhosis
Eric Gershwin, MD
UC Davis |
Session 4: TLRs and Metabolic Pathways in Fatty Liver Diseases
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2:10-2:40pm
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Rp105 in Insulin Resistance and Fatty Liver
Chris Karp, MD
Cincinnati Children’s Hospital |
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2:40-3:10pm
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Nuclear Receptor-Mediated Repression of Inflammation; Lessons from the Brain
Kaoru Saijo, MD, PhD
UCSD School of Medicine |
| 3:10-3:40pm |
Break |
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3:40-4:10pm
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Toll-like Pathways and Nuclear Receptors
Genhong Cheng, PhD
University of California, Los Angeles |
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4:10-4:40pm
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MyD88-Dependent and–Independent Pathways in Alcoholic and Non-Alcoholic Fatty Liver
Pranoti Mandrekar, PhD
University of Massachusetts Medical Center |
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4:40-5:10pm
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TLR4 and Kupffer Cells in NASH
Chantal Rivera, MD
Louisiana University |
| 5:10-5:30pm |
Day 2 Wrap-up |
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| 5:30-7:00pm |
Poster |
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| 7:00pm |
Dinner |
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Monday, September 14, 2009
8:00-8:10am Opening Remarks
Session 5: Linking Liver Regeneration, Fibrosis and Cancer
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8:10-8:40am
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NF-kB Signaling, TLRs and Hepatocellular Cancer
Guobin He, MD, PhD
University of California, San Diego |
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8:40-9:10am
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TLR4, Liver Tumors and Alcohol
Keigo Machida, MD
University of Southern California, School of Medicine |
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9:10-9:40am
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TLRs and Liver Fibrosis
David Brenner, MD
UCSD School of Medicine |
| 9:40-10:10am |
TLR4-Dependent Leukocyte Homing to the Liver is Mediated by the Secretion of CXCL1 by Hepatic Stellate Cells
Amelie E. Bigorgne |
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| 10:10-10:40am |
Break |
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Session 6: TLR from Bench to Bedside
| 10:40-11:10am |
Clinical and Preclinical Studies with ANA773, an Oral Prodrug of a TLR7 Agonist, Suggests Therapeutic Potential in Patients Chronically Infected by HCV
Simon Fletcher |
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11:10-11:40am
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Novel Small Molecule TLR7 and TLR8 Agonists
Ekambar Kandimalla, MD
Idera Pharmaceuticals |
Tentative Program (Note: Topics and speakers are subject to change.)