Hepatology April Table of Contents 

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Comments from the Editors

The perils and promise of high-dimensional biology

Editorials

Hepatitis B surface antigen quantification as a current-day paradox: Obtaining the gold in the face of diminishing returns

Antiangiogenic therapy: Not just for cancer anymore?

Viral Hepatitis

Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy

Factors of accuracy of transient elastography (fibroscan) for the diagnosis of liver fibrosis in chronic hepatitis C

HBV superinfection in HCV chronic carriers: A disease that is frequently severe but associated with the eradication of HCV

Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma

Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: Similar effectiveness of lamivudine, tenofovir, or combination therapy

Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B

Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients

The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains

Steatohepatitis/Metabolic Liver Disease

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

Hepatobiliary Malignancies

Radiologic-pathologic correlation of hepatocellular carcinoma treated with internal radiation using yttrium-90 microspheres

MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma

Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-  signaling from tumor suppression to oncogenesis in early chronic hepatitis B

Autoimmune, Cholestatic and Biliary Disease

A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

Liver Failure/Cirrhosis/Portal Hypertension

Computer-assisted image analysis of liver collagen: Relationship to Ishak scoring and hepatic venous pressure gradient

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

Detection of novel biomarkers of liver cirrhosis by proteomic analysis

Liver Injury/Regeneration

Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice

CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)- -induced apoptosis

Liver Biology/Pathobiology

Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative

An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice

AASLD Practice Guidelines

Diagnosis, management, and treatment of hepatitis C: An update

Rapid Communication

Differential expression of lumican and fatty acid binding protein-1: New insights into the histologic spectrum of nonalcoholic fatty liver disease

Hepatology Elsewhere

Advanced chronic hepatitis C: How to handle if you cannot halt?

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumors

Image of the Month

A woman with chronic anemia and cholestatic liver disease

Correspondence

Histological changes in hepatitis C virus antibody-positive, hepatitis C virus RNA-negative subjects suggest persistent virus infection

Reply

How does bacterial DNA induce liver failure in cirrhosis?

Reply

Insulin resistance and platelet count/spleen diameter ratio: Two simple, easy-to-get tests for predicting esophageal varices in cirrhosis

Reply

A crossing in therapy for hepatitis C virus genotype 2 or 3: Increasing ribavirin dose with shortened duration or reducing ribavirin dose with standard duration

Reply

Liver failure as initial presentation of autoimmune hepatitis: Clinical characteristics, predictors of response to steroid therapy, and outcomes

The Cobas AmpliPrep-Cobas TaqMan real-time polymerase chain reaction assay fails to detect hepatitis C virus RNA in highly viremic genotype 4 clinical samples

Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity

Emerging new chemokine CXCR3 antagonists and their potential clinical and therapeutic applications