Hepatology Table of Contents 

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TABLE OF CONTENTS
Volume 51 Issue 4 , Pages 1095 - 1478 (April 2010)

Master's Perspective
Biliary physiology and disease: Reflections of a physician-scientist (p 1095-1106)
Gustav Paumgartner
Published Online: Nov 30 2009 2:46PM
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Editorials
Should antiviral treatment be extended to patients with chronic hepatitis B and mildly elevated alanine aminotransferase? (p 1107-1109)
Anna S. Lok
Published Online: Dec 9 2009 7:09PM
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Inhibition of mammalian target of rapamycin: The janus face of immunosuppression? (p 1113-1115)
Christopher Soll, Pierre-Alain Clavien
Published Online: Feb 3 2010 10:31AM
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Partial hepatectomy versus radiofrequency ablation for hepatocellular carcinoma: Confirming the trial that will never be, and some comments on the indications for liver resection (p 1116-1118)
Pietro E. Majno, Gilles Mentha, Vincenzo Mazzaferro
Published Online: Mar 1 2010 3:13PM
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Hemochromatosis gene (HFE) mutations and cancer risk: Expanding the clinical manifestations of hereditary iron overload (p 1119-1121)
Silvia Fargion, Luca Valenti, Anna Ludovica Fracanzani
Published Online: Jan 28 2010 9:46AM
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Viral Hepatitis
Twelve weeks posttreatment follow-up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin (p 1122-1126)
Michelle Martinot-Peignoux, Christiane Stern, Sarah Maylin, Marie-Pierre Ripault, Nathalie Boyer, Laurence Leclere, Corinne Castelnau, Nathalie Giuily, Ahmed El Ray, Ana-Carolina Cardoso, Rami Moucari, Tarik Asselah, Patrick Marcellin
Published Online: Nov 30 2009 2:46PM
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Effectiveness of hepatitis C treatment with pegylated interferon and ribavirin in urban minority patients (p 1137-1143)
Paul Feuerstadt, Ari L. Bunim, Heriberto Garcia, Jordan J. Karlitz, Hatef Massoumi, Amar J. Thosani, Andrew Pellecchia, Allan W. Wolkoff, Paul J. Gaglio, John F. Reinus
Published Online: Nov 13 2009 2:10PM
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Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations (p 1144-1157)
Sophie E. Krieger, Mirjam B. Zeisel, Christopher Davis, Christine Thumann, Helen J. Harris, Eva K. Schnober, Christopher Mee, Eric Soulier, Cathy Royer, Mélanie Lambotin, Fritz Grunert, Viet Loan Dao Thi, Marlène Dreux, François-Loïc Cosset, Jane A. McKeating, Catherine Schuster, Thomas F. Baumert
Published Online: Nov 30 2009 2:46PM
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Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C (p 1158-1167)
Salvatore Petta, Calogero Cammà, Concetta Scazzone, Claudio Tripodo, Vito Di Marco, Antonino Bono, Daniela Cabibi, Giusalba Licata, Rossana Porcasi, Giulio Marchesini, Antonio Craxí
Published Online: Dec 4 2009 10:08AM
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Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus (p 1168-1175)
Susanne Knapp, Usama Warshow, Doha Hegazy, Louise Brackenbury, I. Neil Guha, Andrew Fowell, Ann-Margaret Little, Graeme J. Alexander, William M.C. Rosenberg, Matthew E. Cramp, Salim I. Khakoo
Published Online: Nov 30 2009 2:46PM
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Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: Systematic review of randomized trials (p 1176-1184)
Tahany Awad, Kristian Thorlund, Goran Hauser, Davor Stimac, Mahasen Mabrouk, Christian Gluud
Published Online: Dec 23 2009 9:09AM
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Efficacy of entecavir in chronic hepatitis B patients with mildly elevated alanine aminotransferase and biopsy-proven histological damage (p 1185-1189)
I-Chin Wu, Ching-Lung Lai, Steven-Huy Bui Han, Kwang-Hyup Han, Stuart C. Gordon, You-Chen Chao, Chee-Kiat Tan, William Sievert, Tawesak Tanwandee, Dong Xu, Boon-Leong Neo, Ting-Tsung Chang
Published Online: Nov 9 2009 9:27AM
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Steatohepatitis/Metabolic Liver Disease
Functional proteomic analysis of nonalcoholic fatty liver disease in rat models: Enoyl-coenzyme a hydratase down-regulation exacerbates hepatic steatosis (p 1190-1199)
Xuequn Zhang, Juntao Yang, Yuanbiao Guo, Hua Ye, Chaohui Yu, Chengfu Xu, Lei Xu, Songfeng Wu, Wei Sun, Hangdong Wei, Xue Gao, Yunping Zhu, Xiaohong Qian, Ying Jiang, Youming Li, Fuchu He
Published Online: Dec 4 2009 10:11AM
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Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo (p 1200-1208)
Nicole K. Paulk, Karsten Wursthorn, Zhongya Wang, Milton J. Finegold, Mark A. Kay, Markus Grompe
Published Online: Nov 30 2009 2:46PM
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Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease (p 1209-1217)
Luca Valenti, Ahmad Al-Serri, Ann K. Daly, Enrico Galmozzi, Raffaela Rametta, Paola Dongiovanni, Valerio Nobili, Enrico Mozzi, Giancarlo Roviaro, Ester Vanni, Elisabetta Bugianesi, Marco Maggioni, Anna Ludovica Fracanzani, Silvia Fargion, Christopher P. Day
Published Online: Feb 23 2010 8:57AM
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Hepatobiliary Malignancies
Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systems (p 1218-1225)
Matthew Hennig, Michele T. Yip-Schneider, Sabrina Wentz, Huangbing Wu, S. K. Hekmatyar, Patrick Klein, Navin Bansal, C. Max Schmidt
Published Online: Nov 30 2009 2:46PM
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Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice (p 1226-1236)
Achim Weber, Regina Boger, Binje Vick, Toni Urbanik, Johannes Haybaeck, Stefan Zoller, Andreas Teufel, Peter H. Krammer, Joseph T. Opferman, Peter R. Galle, Marcus Schuchmann, Mathias Heikenwalder, Henning Schulze-Bergkamen
Published Online: Nov 30 2009 2:46PM
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Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma (p 1237-1243)
Christian Toso, Shaheed Merani, David L. Bigam, A.M. James Shapiro, Norman M. Kneteman
Published Online: Nov 13 2009 2:08PM
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Serotonin promotes tumor growth in human hepatocellular cancer (p 1244-1254)
Christopher Soll, Jae Hwi Jang, Marc-Oliver Riener, Wolfgang Moritz, Peter Johannes Wild, Rolf Graf, Pierre-Alain Clavien
Published Online: Nov 20 2009 12:39PM
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Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma (p 1255-1263)
Dong-Jiang Tang, Sui-Sui Dong, Ning-Fang Ma, Dan Xie, Leilei Chen, Li Fu, Sze Hang Lau, Yan Li, Yan Li, Xin-Yuan Guan
Published Online: Nov 30 2009 2:46PM
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Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9 (p 1264-1273)
Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Hisashi Ishida, Takuya Miyagi, Atsushi Hosui, Norio Hayashi
Published Online: Nov 30 2009 2:46PM
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A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma (p 1274-1283)
Giuseppe Cabibbo, Marco Enea, Massimo Attanasio, Jordi Bruix, Antonio Craxì, Calogero Cammà
Published Online: Dec 4 2009 10:11AM
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Hepatic resection versus radiofrequency ablation for very early stage hepatocellular carcinoma: A Markov model analysis (p 1284-1290)
Yun Ku Cho, Jae Kyun Kim, Wan Tae Kim, Jin Wook Chung
Published Online: Nov 30 2009 2:46PM
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Autoimmune, Cholestatic and Biliary Disease
Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice (p 1291-1301)
Heping Yang, Kwangsuk Ko, Meng Xia, Tony W.H. Li, Pilsoo Oh, Jiaping Li, Shelly C. Lu
Published Online: Nov 30 2009 2:46PM
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The predictors of the presence of varices in patients with primary sclerosing cholangitis (p 1302-1310)
Sombat Treeprasertsuk, Kris V. Kowdley, Velimir A. C. Luketic, M. Edwyn Harrison, Timothy McCashland, Alex S. Befeler, Denise Harnois, Roberta Jorgensen, Jan Petz, Jill Keach, Jeff Schmoll, Tanya Hoskin, Prabin Thapa, Felicity Enders, Keith D. Lindor
Published Online: Nov 13 2009 2:09PM
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HFE C282Y homozygotes are at increased risk of breast and colorectal cancer (p 1311-1318)
Nicholas J. Osborne, Lyle C. Gurrin, Katrina J. Allen, Clare C. Constantine, Martin B. Delatycki, Christine E. McLaren, Dorota M. Gertig, Gregory J. Anderson, Melissa C. Southey, John K. Olynyk, Lawrie W. Powell, John L. Hopper, Graham G. Giles, Dallas R. English
Published Online: Nov 30 2009 2:46PM
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Liver Failure/Cirrhosis/Portal Hypertension
Disruption of the growth hormone - Signal transducer and activator of transcription 5 - Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis (p 1319-1326)
Leander Blaas, Jan-Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova
Published Online: Nov 30 2009 2:46PM
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Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis (p 1327-1333)
Beate Appenrodt, Frank Grünhage, Martin G. Gentemann, Lydia Thyssen, Tilman Sauerbruch, Frank Lammert
Published Online: Nov 20 2009 12:39PM
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Liver Injury/Regeneration
Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes (p 1334-1344)
Giuseppe Lo Sasso, Nicola Celli, Mariaelena Caboni, Stefania Murzilli, Lorena Salvatore, Annalisa Morgano, Michele Vacca, Tommaso Pagliani, Paolo Parini, Antonio Moschetta
Published Online: Nov 13 2009 2:08PM
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CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis (p 1345-1353)
Mirko Moreno Zaldivar, Katrin Pauels, Philipp von Hundelshausen, Marie-Luise Berres, Petra Schmitz, Jörg Bornemann, M. Anna Kowalska, Nikolaus Gassler, Konrad L. Streetz, Ralf Weiskirchen, Christian Trautwein, Christian Weber, Hermann E. Wasmuth
Published Online: Nov 13 2009 2:09PM
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Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity (p 1354-1362)
Hua Wang, Ogyi Park, Fouad Lafdil, Kezhen Shen, Norio Horiguchi, Shi Yin, Xin-Yuan Fu, George Kunos, Bin Gao
Published Online: Nov 13 2009 2:10PM
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The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse (p 1363-1372)
Yoichiro Uchida, Bibo Ke, Maria Cecilia S. Freitas, Haofeng Ji, Danyun Zhao, Elizabeth R. Benjamin, Nader Najafian, Hideo Yagita, Hisaya Akiba, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski
Published Online: Nov 30 2009 2:46PM
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Role of transforming growth factor betasignaling and expansion of progenitor cells in regenerating liver (p 1373-1382)
Arun Thenappan, Ying Li, Krit Kitisin, Asif Rashid, Kirti Shetty, Lynt Johnson, Lopa Mishra
Published Online: Nov 30 2009 2:46PM
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Liver Biology/Pathobiology
Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma (p 1383-1390)
Markus Reschke, Ingvar Ferby, Ewa Stepniak, Nina Seitzer, David Horst, Erwin F. Wagner, Axel Ullrich
Published Online: Nov 13 2009 2:10PM
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Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice (p 1391-1400)
Erin E. Sparks, Kari A. Huppert, Melanie A. Brown, M. Kay Washington, Stacey S. Huppert
Published Online: Nov 13 2009 2:09PM
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Progenitor-derived hepatocellular carcinoma model in the rat (p 1401-1409)
Jesper B. Andersen, Roberto Loi, Andrea Perra, Valentina M. Factor, Giovanna M. Ledda-Columbano, Amedeo Columbano, Snorri S. Thorgeirsson
Published Online: Dec 4 2009 10:11AM
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Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine (p 1410-1419)
Ann M. Thomas, Steven N. Hart, Bo Kong, Jianwen Fang, Xiao-bo Zhong, Grace L. Guo
Published Online: Nov 30 2009 2:46PM
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The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells (p 1420-1429)
Palash Mandal, Pil-Hoon Park, Megan R. McMullen, Brian T. Pratt, Laura E. Nagy
Published Online: Nov 13 2009 2:10PM
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Rapid Communication
Bioluminescence imaging allows measuring CD8 T cell function in the liver (p 1430-1437)
Dirk Stabenow, Marianne Frings, Christina Trück, Katja Gärtner, Irmgard Förster, Christian Kurts, Thomas Tüting, Margarete Odenthal, Hans-Peter Dienes, Karin Cederbrant, Ulrike Protzer, Percy A. Knolle
Published Online: Feb 3 2010 10:31AM
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Reviews
Portal fibroblasts: Underappreciated mediators of biliary fibrosis (p 1438-1444)
Jonathan A. Dranoff, Rebecca G. Wells
Published Online: Oct 23 2009 10:07AM
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Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis (p 1445-1449)
Guadalupe Garcia-Tsao, Scott Friedman, John Iredale, Massimo Pinzani
Published Online: Nov 30 2009 2:46PM
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Hepatobiliary Complications of Hematopoietic Cell Transplantation, 40 Years On (p 1450-1460)
George B. McDonald
Published Online: Jan 28 2010 9:46AM
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Hepatology Elsewhere
Antagonizing MicroRNA-122 and treatment of hepatitis C virus infection (p 1461-1463)
Sébastien Pfeffer, Thomas F. Baumert
Published Online: Mar 29 2010 2:30PM
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Patatin-like phospholipase domain containing 3: A case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease (p 1463-1465)
Devanshi Seth, Ann K. Daly, Paul S. Haber, Christopher P. Day
Published Online: Mar 29 2010 2:30PM
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Image of the Month
Madelung's disease and alcoholic liver disorder (p 1466-1467)
Mei-Ju Ko, Hsien-Ching Chiu
Published Online: Nov 30 2009 2:46PM
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Correspondence
No contribution to liver fibrosis, but possible carcinogenesis? (p 1468-1469)
Da-Wei Zhang, Huijie Bian
Published Online: Feb 19 2010 3:18PM
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Reply (p 1469)
Kojiro Taura, Kouichi Miura, David Brenner
Published Online: Feb 19 2010 3:17PM
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Importance of the compensatory anti-inflammatory response following severe sepsis on cirrhosis (p 1469-1470)
Philip A. Berry, Charalambos G. Antoniades, Julia Wendon
Published Online: Jan 28 2010 9:46AM
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Reply (p 1470)
Thierry Gustot, Richard Moreau
Published Online: Feb 19 2010 3:17PM
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A missing link in the puzzle: Brown adipose tissue (p 1470-1471)
Tugrul Purnak, Ersan Ozaslan, Cumali Efe, Hasan Sevimler
Published Online: Jan 28 2010 9:46AM
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Reply (p 1471-1472)
Elisa Fabbrini, Shelby Sullivan, Samuel Klein
Published Online: Mar 29 2010 2:29PM
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The link between hepatosteatosis and cells of the immune system (p 1472)
Anna Alisi, Nadia Panera, Valerio Nobili
Published Online: Jan 28 2010 9:46AM
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Reply (p 1472-1473)
Ian N. Hines
Published Online: Mar 1 2010 3:13PM
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Non-HFE-related hemochromatosis: The role of genetic factors (p 1473-1474)
Agustin Castiella, Eva Zapata, Pedro Otazua, Leire Zubiaurre, Javier Fernandez
Published Online: Feb 19 2010 3:18PM
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Reply (p 1474)
Anna Ludovica Fracanzani, Alberto Piperno, Luca Valenti, Silvia Fargion
Published Online: Mar 1 2010 3:13PM
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Matrix metalloproteinase-9 in fulminant hepatic failure (p 1475-1476)
Lluis Palenzuela, Antoni Mas, Joan Montaner, Juan Cordoba
Published Online: Jan 28 2010 9:46AM
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Reply (p 1476)
Justin H. Nguyen
Published Online: Mar 1 2010 3:13PM
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Toll-like receptor 4 status influences hepatic metabolism, although its interaction with a high-fructose, energy, and prebiotic diet remains uncertain (p 1477)
Richard D. Johnston, Ian A. MacDonald, Guruprasad P. Aithal
Published Online: Feb 1 2010 12:01PM
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Reply (p 1477-1478)
Ina Bergheim, Astrid Spruss
Published Online: Mar 1 2010 3:13PM
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