Hepatology Editor's Picks 

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Alcoholic Cirrhosis Patients had High Prevalence of Complications at Diagnosis 

A recent study by Danish researchers discovered patients with alcoholic cirrhosis had a high prevalence of complications at the time of the disease diagnosis. Researchers noted that complications, such as ascites (excessive fluid in the abdomen), were predictors of mortality, but did not develop in a predictable sequence. 

“Our findings demonstrate that alcoholic cirrhosis patients have a high prevalence of complications at the time of their diagnosis,” said Dr. Jepsen. These complications are strong predictors of one-year mortality, but not of the risk of developing more complications. Due to the random sequence of complication development the clinical course of alcoholic cirrhosis cannot be determined based on the presence or absence of particular cirrhosis complications.

Cigarette Smoking, Fructose Consumption Exacerbate Liver Disease 

Recent studies suggest that modifiable risk factors such as cigarette smoking and fructose consumption can worsen nonalcoholic fatty liver disease (NAFLD). Past studies indicate that more than 30 million Americans have NAFLD and approximately 8 million may have nonalcoholic steatohepatitis (NASH). Researchers found that obese rats exposed to cigarette smoking showed a significant increase in ALT serum levels (indicating liver disease) and worsens the severity of NAFLD in obese rats.  

In patients with NAFLD, daily fructose ingestion was associated with reduced fatty liver (steatosis), but increased fibrosis. A second fructose study investigated the effects of curcumin on fructose-induced hypertriglyceridemia and fatty liver in rats. Curcumin, a compound derived from turmeric (curcuma root), is sold as an herbal supplement and is believed to have anti-inflammatory, anti-tumor, and anti-viral properties. Novel insights into the potential therapeutic mechanisms of curcumin on fructose-induced hepatic steatosis associated with insulin and leptin resistance were provided.

These studies indicate modifying risks such as smoking and fructose consumption offer potential benefits for those with liver diseases. Further studies are needed to explore these benefits in preventing the progression of liver disease.