Hepatology June Table of Contents 

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Master's Persective

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

Comments from the Editors
Hepatology as a model for health care

Editorials

Golgi protein 73 as a biomarker of hepatocellular cancer: Development of a quantitative serum assay and expression studies in hepatic and extrahepatic malignancies

Hepatic progenitor cell-mediated regeneration and fibrosis: Chicken or egg?

Pioglitazone: More than just an insulin sensitizer

Viral Hepatitis

Hepatitis C virus persisting after clinically apparent sustained virological response to antiviral therapy retains infectivity in vitro

Elevations in alanine aminotransferase levels late in the course of antiviral therapy in hepatitis C virus RNA-negative patients are associated with virological relapse

Seroconversion to hepatitis C virus alternate reading frame protein during acute infection

The cyclophilin inhibitor Debio 025 combined with PEG IFN2a significantly reduces viral load in treatment-naïve hepatitis C patients

Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways

Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model

Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma

Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy

Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3 kinase pathways 

Steatohepatitis/Metabolic Liver Disease

Loss of protein kinase C function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice

Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats
 
Hepatobiliary Malignancies

Association between hypothyroidism and hepatocellular carcinoma: A case-control study in the United States

MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas 

Liver Failure/Cirrhosis/Portal Hypertension

Impact of pretransplant hyponatremia on outcome following liver transplantation

Liver Injury/Regeneration

Bile salt-induced pro-oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long-Evans Cinnamon rat model

Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury

Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-Ay mice

Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice

Liver Biology/Pathobiology

Locating the stem cell niche and tracing hepatocyte lineages in human liver

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization

ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver

Age-related decrease in proteasome expression contributes to defective nuclear factor-B activation during hepatic ischemia/reperfusion

AASLD Practice Guidelines

Vascular disorders of the liver

Hepatology Elsewhere

Adipocyte-hepatocyte crosstalk and the pathogenesis of nonalcoholic fatty liver disease

The structure behind diversity: Covariance networks in hepatitis C virus sequences are associated with treatment response

Closing the gap: The tight junction protein occludin and hepatitis C virus entry

Image of the Month

Ascites and variceal bleeding occurring in a 20-year-old with cystic fibrosis

Correspondence

Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis

Insulin resistance in prediction of esophageal varices

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Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to drug-induced liver injury

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Hepatitis B virus clearance rate estimates

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Hemochromatosis: Platelets and aspartate aminotransferase are useful high-degree fibrosis marker

Reply: Utility of platelets and aspartate aminotransferase vs serum ferritin and serum hyaluronic acid as markers of cirrhosis in hemochromatosis

Validation of simplified diagnostic criteria for autoimmune hepatitis in Italian patients

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Values for upper limit of normal should be given for liver enzymes

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