Dr. Lok is the Alice Lohrman Andrews Research Professor in Hepatology at the Department of Internal Medicine at the University of Michigan Health System in Ann Arbor, MI. She is also Director of Clinical Hepatology and Associate Chair for Clinical Research, in the Department of Internal Medicine.
Dr. Lok obtained her medical degree from University of Hong Kong in Hong Kong and her hepatology training under the late Dame Sheila Sherlock at the Royal Free Hospital in London, UK. She was a faculty at the University of Hong Kong until she moved to the United States in 1992. Dr. Lok was the Chief of Hepatology at Tulane University in New Orleans in 1992-5 and was recruited to the University of Michigan in 1995.
Dr. Lok's research focuses on the natural history and treatment of hepatitis B and C. She was one of the first to describe the different phases of chronic HBV infection and transition as well as reversion from one phase to another, the incidence of reactivation of HBV replication in patients receiving chemotherapy, the association between pretreatment aminotransferase levels and response to antiviral therapy for hepatitis B, and the prevalence and clinical significance of HBV genotypes and precore/core promoter variants. Her research has been supported by federal grants from the Veterans Health Administration and the National Institutes of Health.
Dr. Lok has published more than 350 articles, reviews, editorials, and book chapters. She is one of the editors of the 12th edition of 'Sherlock's Diseases of the Liver and Biliary System.' She is also a co-author of the AASLD Guidelines on Hepatitis B. Dr. Lok served as Associate Editor of HEPATOLOGY in 2001-6, Co-Editor of Journal of Viral Hepatitis in 2007-9, and Senior Associate Editor of GASTROENTEROLOGY in 2011-2.
Dr. Lok has served on various NIH study sections as well as Research Award Panels of the American Liver Foundation (ALF) and the American Gastroenterological Association (AGA). She was a member of the ALF National Board of Directors in 2004-7.
Dr. Lok joined AASLD in 1988 and served on many committees, including Membership and Mentorship Committee, Publication Committee, Hepatology Associates Committee, Scientific Program Committee, Clinical Research Committee, Training and Workforce Committee and International Education Committee. She currently serves on the Global Outreach and Engagement Committee, Governing Board and Nominating Committee. Dr. Lok served as a Councilor-at-Large in 2001-3.
Dr. Lok has trained numerous fellows and junior faculty from all over the world. Her dedication to training and mentoring was recognized by the Michigan Institute for Clinical and Health Research Distinguished Mentor Award in 2012. Dr. Lok received many other awards throughout her career. Recent awards include the Distinguished Scientist Award from the Hepatitis B Foundation and the Distinguished Women Scientist from the AGA in 2008, and the Distinguished Service Award from the AASLD in 2011. She was inducted into the Association of American Physicians in 2012.
Conflict of Interest
Dr. Anna S. Lok has received research grants from Bristol-Myers Squibb, Gilead Sciences and Target Pharma.