Dr. Laurie D. DeLeve has been on the faculty at the University of Southern California in Los Angeles since 1990 and is Professor of Medicine and Senior Associate Chair for Scientific Affairs in the Department of Medicine at the Keck School of Medicine. She received her MD at the Erasmus University of Rotterdam in the Netherlands and her PhD at the University of Toronto in Canada. She did her training in Internal Medicine at the University of Michigan in Ann Arbor, followed by a fellowship in Gastroenterology/Hepatology at UCLA. Dr. DeLeve is a physician scientist and is involved in patient care, basic research, and education of medical student, residents and Fellows.
Dr DeLeve’s NIH-funded research has focused on the biology and pathobiology of liver sinusoidal endothelial cells (LSECs). Early work from her laboratory demonstrated that LSECs were the initial target in sinusoidal obstruction syndrome and these studies provided significant insight into the mechanisms of this syndrome. Subsequent research examined the role of LSECs in other forms of injury. In recent years, Dr. DeLeve’s lab was the first to identify resident and bone marrow sinusoidal endothelial cell progenitor cells, so-called bone marrow sprocs. Her laboratory is currently examining the role of bone marrow sprocs in acute and chronic liver injury. In acute injury, bone marrow sprocs are critical for repair of liver injury and drive liver regeneration.
AASLD has been Dr. DeLeve’s professional home since she completed her Fellowship and she has been a member since 1991. She has served the society in several ways. She has been a Councilor-at-Large, member and Chair of the Education Committee, Chair of the Federal Agency Liaison Committee, Chair of the International Education Sub-committee, Chair of the Educational Materials Committee, and member of the Scientific Planning committee, the CME Oversight committee, the Basic Research Committee, the Awards Committee, and a member of the Steering committee for the Fibrosis SIG. She (co)-organized a Single Topic Conference, two Clinical Updates in Hepatology, and an AASLD Federal Roundtable. She has participated in abstract review panels, chaired annual meeting sessions, and moderated Early Morning workshops.
Conflict of Interest
Dr. Laurie DeLeve consults for Daiichi Sankyo, Seagen and Pfizer.