Lopa Mishra, MD, FAASLD
George Washington University
Lopa Mishra, M.D. is currently Director, Center for Translational Medicine, Department of Surgery, George Washington University from 2015 where she moved from Houston Texas. Dr. Mishra was at MD Anderson from December 2009 until 2015, as Professor and Chair of Gastroenterology, Hepatology and Nutrition. In 2010, she was named holder of the endowed position: Del & Dennis McCarthy Distinguished Professorship. Dr. Mishra also served as Associate Director of the Texas Digestive Diseases Center, an NCI-funded, multi-investigator program project in gastrointestinal (GI) cancers.
Under Dr. Mishra’s leadership, the department grew from one clinical program to eight programs in GI cancers, including a major colon cancer prevention program. The department’s outstanding faculty, some of whom Dr. Mishra has recruited, are ranked among the nation’s leaders in the prevention, diagnosis and treatment of diseases of the digestive tract and liver with a substantial focus on cancers. One example of the department’s outstanding work is the 2013 “exceptional-outstanding” score from the National Cancer Institute of the Gastrointestinal Cancer Program (GICP) for the Cancer Center Support Grant. Reflecting her strong commitment to education, Dr. Mishra re-energized the fellowship program between MD Anderson and UT Houston. Dr. Mishra’s efforts extended far beyond Houston: she initiated the first MD Anderson Global Academic Program with sub-Saharan Africa, including Ethiopia, Kenya and South Africa.
Dr. Mishra’s work is in developing new therapeutics targeting liver cancer. She discovered that that the TGF-β pathway is the effector pathway for the human stem cell syndrome with an 800fold risk of cancer (Beck-Wiedmann Syndrome), Science 2003,2005, PNAS, 2008, JNCI 2012, JCI, 2013, 2016-in press. Dr. Mishra’s linking of TGF-β signaling with changes in E-cadherin and β-catenin for the first time in a human disease provide important clues to a common basis for the development of human liver and gastrointestinal cancers. Her current focus on mechanistic studies identifying key signaling pathways in foregut cancers, which has led her to explore new therapeutics targeted at liver and gastrointestinal cancer. Studies have yielded potentially powerful insights into the origins of lethal hepatocellular carcinoma, 40% of which are clonal and could arise from STICs, thus providing key insights using TGF-beta signaling to target subpopulations who could respond to treatment.
Her research has led to more than 200 peer review articles. She has mentored over 70 physicians and scientists- many to leadership positions in academic medicine and science. For her outstanding work, Dr. Mishra has received many honors including: American Gastroenterological Association Award for Top Women in Gastroenterology (2008), Funderburg Scholar in Gastric Cancer (2003-05), Betty and Harry Myerberg Award for Excellence in Research in Liver Development (1998), Elisabeth and John Cox Award for Innovative Clinical Therapy of Esophageal Cancer (1996), USV Industry New Investigator Award (1995) and the Stuart Mill Prize in Tropical Medicine (1981). In 2015, she was elected Fellow of the American Association for the Advancement of Science (AAAS). AAAS Fellows are elected by members of the 141-year-old organization.
Disclosures of Potential Conflicts of Interest
Dr. Lopa Mishra has no conflicts.