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Friday, September 14, 2018 - 8:00 am to Saturday, September 15, 2018 - 5:00 pm
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Course Description / Need Statement

The Hepatic Fibrosis: New Concepts and Controversies conference will serve as an update on current progress made in hepatic fibrosis with many new discoveries that have shaped the field including basic research of fibrosis and the role of the microbiome and gut-liver axis. In addition, significant new information about non-alcoholic fatty liver disease and the potential role of nonparenchymal cells in fibrosis, with emphasis on nonparenchymal-stellate cell crosstalk will be discussed. Also, translational aspects of fibrosis and cirrhosis, including translation of findings into humans as well as discoveries that may lead to novel therapies will be covered.

Program Chairs

  • Don C. Rockey, MD, FAASLD
  • Meena B. Bansal, MD
  • Natalie J. Torok, MD, MSc, FAASLD

Location

  • Hyatt Regency DFW International Airport
    DFW Airport, TX

Continuing Education

  • CME – 11 AMA PRA Category 1 Credits™

Travel Note

US residents: Please review the Real ID Act regarding boarding federally regulated commercial aircrafts. Depending on your state of residence, you may need to provide a second form of identification at the airport.

Schedule Note

Breakfast is served at 7 am ET both days.

Registration Pricing Early Bird: On or Before August 17

  • Member $325
  • Trainee & Assoc. Members $185
  • Student Member $90
  • Non-Member $540
    Any physician, scientist, or researcher with doctoral-level training who is not employed by Industry (pharma/device/etc.)
  • Trainee & Assoc. Non-Member $235
    Any physician, scientist or researcher in a training program as certified by the director of their training program. This category also includes, but is not limited to, the degrees of MS, NP, PA, RN, and other related or comparable degrees.
  • Student Non-Member $115
  • Industry $775
    Any Industry (pharma/device/etc.) employee with or without medical training.

* Requests for cancellations must be submitted in writing to meetings@aasld.org. Cancellations received on or before August 17 will be refunded in full. Refunds between August 18 and August 30 will be subject to a $50.00 cancellation fee. Cancellations on or after August 31 are not eligible for a refund.

Registration Pricing: On or After August 17

  • Member $425
  • Trainee & Assoc. Members $210
  • Student Member $105
  • Non-Member $640
    Any physician, scientist, or researcher with doctoral-level training who is not employed by Industry (pharma/device/etc.)
  • Trainee & Assoc. Non-Member $260
    Any physician, scientist or researcher in a training program as certified by the director of their training program. This category also includes, but is not limited to, the degrees of MS, NP, PA, RN, and other related or comparable degrees.
  • Student Non-Member $130
  • Industry $875
    Any Industry (pharma/device/etc.) employee with or without medical training.

* Requests for cancellations must be submitted in writing to meetings@aasld.org. Cancellations received on or before August 17 will be refunded in full. Refunds between August 18 and August 30 will be subject to a $50.00 cancellation fee. Cancellations on or after August 31 are not eligible for a refund.

Friday, September 14 -- Session I

Session I: Biology of Organ Fibrosis, What’s New?
Moderators: Don C. Rockey, MD, FAASLD and Rebecca G. Wells, MD

  • 8:00 am – 8:10 am
    Welcome and Opening Remarks
    Don C. Rockey, MD, FAASLD
  • 8:10 am – 8:30 am
    Liver Fibrosis from 2006-2017: Where We’ve Been and Where We Are Heading?
    Rebecca G. Wells, MD
  • 8:30 am – 8:40 am
    Discussion
  • 8:40 am – 9:00 am
    Mechanisms of Lung Fibrosis
    Victor J. Thannickal, MD
  • 9:00 am – 9:10 am
    Discussion
  • 9:10 am – 9:30 am
    Lessons Learned from Skin Fibrosis
    Carol Feghali Bostwick PhD
  • 9:30 am – 9:40 am
    Discussion
  • 9:40 am – 10:10 am
    Break

Friday, September 14 -- Session II

Session II: Microbiome, Immunity, and Fibrosis: The Gut-Liver Axis
Moderators: Meena B. Bansal, MD and Bernd Schnabl, MD

  • 10:10 am – 10:30 am
    The Microbiome and the Liver
    Arash Grakoui, PhD
  • 10:30 am – 10:40 am
    Discussion
  • 10:40 am – 11:00 am
    Gut-Liver Axis and Fibrosis
    Bernd Schnabl, MD
  • 11:00 am – 11:10 am
    Discussion
  • 11:10 am – 11:30 am
    The Role of Adaptive Immunity in the Gut in Liver Fibrosis
    Khalidur Rahman, PhD
  • 11:30 am – 11:40 am
    Discussion
  • 11:45 am – 1:15 pm
    Lunch and Poster Viewing

Friday, September 14 -- Session III

Session III: NASH, Fibrosis Progression and HCC in NAFLD
Moderators: Ekihiro Seki, MD, PhD and Robert F. Schwabe, MD

  • 1:15 pm – 1:35 pm
    Mechanisms of NASH-related Fibrosis
    Anna Mae Diehl, MD, FAASLD
  • 1:35 pm – 1:45 pm
    Discussion
  • 1:45 pm – 2:05 pm
    Fibrosis Progression in NASH: Slow or Fast -- The Geneticist’s Perspective
    Elizabeth K. Speliotes, MD, PhD, MPH
  • 2:05 pm – 2:15 pm
    Discussion
  • 2:15 pm – 2:35 pm
    Angiocrine Signaling in Fibrosis and HCC
    Vijay Shah, MD
  • 2:35 pm – 2:45 pm
    Discussion
  • 2:45 pm – 3:05 pm
    Cutting to the Chase: Modeling Common Aberrations in HCC Irrespective of Etiology and Fibrosis
    Satdarshan (Paul) Singh Monga, MD, FAASLD
  • 3:05 pm – 3:15 pm
    Discussion
  • 3:15 pm – 3:35 pm
    Myofibroblasts and Tumor Microenvironment in NASH / HCC
    Robert F. Schwabe, MD
  • 3:35 pm – 3:45 pm
    Discussion

Friday, September 14 -- Session IV

Session IV: Nonparenchymal Cells and Fibrosis
Moderators: Rebecca G. Wells, MD and Cynthia Ju, PhD

  • 3:45 pm – 4:05 pm
    The Role of the Macrophages in Resolving Inflammation
    Cynthia Ju, PhD
  • 4:05 pm – 4:25 pm
    The Origin and Contribution of LSECs to Fibrosis
    Laurie D. DeLeve, MD, PhD, FAASLD
  • 4:25 pm – 4:45 pm
    Endothelial Cell-derived Factors in Fibrosis and HCC
    Hellmut G. Augustin, MD, PhD
  • 4:45 pm – 5:00 pm
    Panel Discussion
  • 5:00 pm – 5:45 pm
    Oral Abstract Presentations

Saturday, September 15 -- Session V

Session V: Emerging Concepts in Liver Fibrosis
Moderators: David Brigstock, PhD, FAASLD and Jelena Mann, MD

  • 8:00 am – 8:10 am
    Opening Remarks
    Meena B. Bansal, MD
  • 8:10 am – 8:30 am
    Proteostasis and Fibrosis Resolution
    Pranoti Mandrekar, MD
  • 8:30 am – 8:40 am
    Discussion
  • 8:40 am – 9:00 am
    Epigenetic Regulation of Stellate Cell Activation
    Jelena Mann, MD
  • 9:00 am – 9:10 am
    Discussion
  • 9:10 am – 9:30 am
    Fibrosis and the Aging Liver
    Natalie J. Torok, MD, MSc, FAASLD
  • 9:30 am – 9:40 am
    Discussion
  • 9:40 am – 10:00 am
    The Exosome as a Driver of Liver Fibrosis
    David Brigstock, PhD, FAASLD
  • 10:00 am – 10:10 am
    Discussion
  • 10:10 am – 10:30 am
    Break

Saturday, September 15 -- Session VI

Session VI: Moving from the Bench to the Bedside in Fibrosis
Moderators: Meena B. Bansal, MD and Manal F. Abdelmalek, MD, MPH, FAASLD

  • 10:30 am – 10:50 am
    Of Mice and Men Or Why Does “Everything” Work in Mice But Not In Humans?: Novel Animal Models
    Ekihiro Seki, MD, PhD
  • 10:50 am – 11:00 am
    Discussion
  • 11:00 am – 11:20 am
    Currently Available and Emerging Antifibrotic Therapies in Human Fibrosis
    Don C. Rockey, MD, FAASLD
  • 11:20 am – 11:30 am
    Discussion
  • 11:30 am – 11:50 am
    Challenges in Clinical Trial Development in Liver Fibrosis
    Manal F. Abdelmalek, MD, MPH, FAASLD
  • 11:50 am – Noon
    Conference Summary and Wrap-Up
    Natalie J. Torok, MD, MSc, FAASLD
  • Noon
    Adjourn