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Matrix Biology and the Liver: Beyond Collagen and Fibrosis

Date/Time

  • Saturday, November 10, 8:00 am - 5:00 pm

Program Chairs

  • Gavin E. Arteel, PhD, FAASLD
  • Rebecca G. Wells, MD

Session Description / Needs Statement

Basic science and clinical practice intersect in this dynamic look at the extracellular matrix (ECM). The ECM consists of a diverse range of components that work bidirectionally with surrounding cells to create a dynamic and responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes to the ECM are well-recognized and understood. However, it is becoming increasingly understood that the hepatic ECM responds dynamically to stress well before fibrosis. Despite this new knowledge, this topic has not been addressed recently. This symposium will bring basic researchers who study ECM in both non-hepatic and liver models together with clinical investigators to focus on new areas of study and promote the use of ECM-directed therapies in human liver disease.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Recognize the diverse and dynamic nature of the hepatic extracellular matrix (ECM) and how it communicates bidirectionally with the hepatic environment
  • Recall factors that influence the ECM, both quantitatively and qualitatively
  • Identify new avenues of therapy and research for ECM in liver diseases

Continuing Education

  • CME – 7.00 AMA PRA Category 1 Credits™

 

Session I: What Is the Matrix of the Liver and Who Makes It?

Moderators: TBD

  • 8:00 am - 8:10 am
    Welcome and Introductions
  • 8:10 am - 8:40 am
    Keynote: Matrisome – Definition and Methods
  • 8:40 am - 9:00 am
    Acute Phase Glycoproteins (Including Liver Matrisome)
  • 9:00 am - 9:20 am
    Heterogeneity in Matrix-Producing Cells
  • 9:20 am - 9:50 am
    Keynote: Collagens of the Liver – A Big Family With Different Functions
  • 9:50 am - 10:05 am
    Panel Discussion
  • 10:05 am -10:25 am
    Break

Session II: 3D Structure of the Matrix: Microscale

Moderators: TBD

  • 10:25 am - 10:55 am
    Keynote: Synthetic Matrices and Their Uses
  • 10:55 am - 11:15 am
    Hyaluronic Acid in the Liver
  • 11:15 am - 11:35 am
    Proteoglycans and Their Role in Regulating ECM Structure and Function
  • 11:35 am - 11:55 am
    Matrix Cross-linking and Structure
  • 11:55 am - 12:10 pm
    Panel Discussion
  • 12:10 pm - 1:30 pm
    Intermission: Meet-the-Professor Luncheons

Session III: 3D Structure of the Matrix: Macroscale

Moderators: TBD

  • 1:30 pm - 2:00 pm
    Keynote: Mechanobiology of Tissues
  • 2:00 pm - 2:20 pm
    The Matrix of the Interstitial Spaces of the Liver and Ducts
  • 2:20 pm - 2:50 pm
    Keynote: New Tools to Study the Matrix
  • 2:50 pm - 3:05 pm
    Panel Discussion
  • 3:05 pm - 3:25 pm
    Break

Session IV: The Matrix in Disease: Therapeutic Implications

Moderators: TBD

  • 3:25 pm - 3:45 pm
    The Matrix as a Direct Therapeutic Target
  • 3:45 pm - 4:05 pm
    ECM Microenvironment and Cancer
  • 4:05 pm - 4:25 pm
    Incorporating the ECM into New Models of the Liver
  • 4:25 pm - 4:50 pm
    Panel Discussion
  • 4:50 pm - 5:00 pm
    Closing Remarks
AASLD Foundation