Basic science and clinical practice intersect in this dynamic look at the extracellular matrix (ECM). The ECM consists of a diverse range of components that work bidirectionally with surrounding cells to create a dynamic and responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes to the ECM are well-recognized and understood. However, it is becoming increasingly understood that the hepatic ECM responds dynamically to stress well before fibrosis. Despite this new knowledge, this topic has not been addressed recently. This symposium will bring basic researchers who study ECM in both non-hepatic and liver models together with clinical investigators to focus on new areas of study and promote the use of ECM-directed therapies in human liver disease.
Upon completion of this activity, participants will be able to: