Sign In

Matrix Biology and the Liver: Beyond Collagen and Fibrosis

Date/Time

  • Saturday, November 10, 8:00 am - 5:00 pm

Program Chairs

  • Gavin E. Arteel, PhD, FAASLD
  • Rebecca G. Wells, MD

Session Description / Needs Statement

Basic science and clinical practice intersect in this dynamic look at the extracellular matrix (ECM). The ECM consists of a diverse range of components that work bidirectionally with surrounding cells to create a dynamic and responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes to the ECM are well-recognized and understood. However, it is becoming increasingly understood that the hepatic ECM responds dynamically to stress well before fibrosis. Despite this new knowledge, this topic has not been addressed recently. This symposium will bring basic researchers who study ECM in both non-hepatic and liver models together with clinical investigators to focus on new areas of study and promote the use of ECM-directed therapies in human liver disease.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Recognize the diverse and dynamic nature of the hepatic extracellular matrix (ECM) and how it communicates bidirectionally with the hepatic environment
  • Recall factors that influence the ECM, both quantitatively and qualitatively
  • Identify new avenues of therapy and research for ECM in liver diseases

Continuing Education

  • CME – 7.00 AMA PRA Category 1 Credits™

 

Session I: What Is the Matrix of the Liver and Who Makes It?

Moderators: David A. Brenner, MD and James P. Luyendyk, PhD

  • 8:00 am - 8:10 am
    Welcome and Introductions
  • 8:10 am - 8:40 am
    Keynote: Matrisome – Definition and Methods
    Alexandra Naba, PhD
  • 8:40 am - 9:00 am
    The Liver Matrisome and Acute Phase Responses
    Gavin E. Arteel, PhD, FAASLD
  • 9:00 am - 9:20 am
    Heterogeneity in Matrix-Producing Cells
    Dean Sheppard, MD
  • 9:20 am - 9:50 am
    Keynote: Collagens of the Liver – A Big Family With Different Functions
    Detlef Schuppan, MD, PhD
  • 9:50 am - 10:05 am
    Panel Discussion
  • 10:05 am -10:25 am
    Break

Session II: 3D Structure of the Matrix: Microscale

Moderators: Harmeet Malhi, MD, MBBS, FAASLD and Scott L. Friedman, MD, FAASLD

  • 10:25 am - 10:55 am
    Keynote: Synthetic Matrices and Their Uses
    Andres Garcia, MD
  • 10:55 am - 11:15 am
    Hyaluronic Acid in the Liver
    Michele Pritchard, PhD
  • 11:15 am - 11:35 am
    Proteoglycans and Their Role in Regulating ECM Structure and Function
    Liliana Schaefer, MD
  • 11:35 am - 11:55 am
    Matrix Cross-linking and Structure
    Yury Popov, MD, PhD
  • 11:55 am - 12:10 pm
    Panel Discussion
  • 12:10 pm - 1:30 pm
    Intermission: Meet-the-Professor Luncheons

Session III: 3D Structure of the Matrix: Macroscale

Moderators: Vijay Shah, MD and Tatiana Kisseleva, MD, PhD

  • 1:30 pm - 2:00 pm
    Keynote: Mechanobiology of Tissues
    Val M. Weaver, PhD
  • 2:00 pm - 2:20 pm
    The Matrix of the Interstitial Spaces of the Liver and Ducts
    Rebecca G. Wells, MD
  • 2:20 pm - 2:50 pm
    Keynote: New Tools to Study the Matrix
    James Fitzpatrick, PhD
  • 2:50 pm - 3:05 pm
    Panel Discussion
  • 3:05 pm - 3:25 pm
    Break

Session IV: The Matrix in Disease: Therapeutic Implications

Moderators: Don C. Rockey, MD, FAASLD and Yasuko Iwakiri, PhD

  • 3:25 pm - 3:45 pm
    The Matrix as a Direct Therapeutic Target
    Jonel Trebicka, MD, PhD
  • 3:45 pm - 4:05 pm
    ECM Microenvironment and Cancer
    Robert F. Schwabe, MD
  • 4:05 pm - 4:25 pm
    Incorporating the ECM into New Models of the Liver
    Robert E. Schwartz, MD, PhD
  • 4:25 pm - 4:50 pm
    Panel Discussion
  • 4:50 pm - 5:00 pm
    Closing Remarks