Sign In

DAMPs and New Receptor Signaling in Liver Disease

Date/Time 

  • Friday, October 20, 8 am-Noon

Program Chairs 

  • Natalia Nieto, PhD
  • Yasuko Iwakiri, PhD

Continuing Education Information

  • CME – 3.75 AMA PRA Category 1 Credits™ 

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Better understand damage-associated molecular patterns (DAMPs) that act as endogenous danger signals to induce and exacerbate inflammatory response.
  • Have a new knowledge of signaling pathways that contribute to the pathophysiology of liver disease.
  • Gain new ideas for clinical treatments and approaches.

Session Description/Needs Statement

Gain a solid background on the mechanisms that activate and potentiate hepatic injury, inflammation and fibrosis through an in-depth presentation of the different yet related basic molecular mechanisms that underlie various types of hepatic damage.

Session I: DAMPs

  • 8-8:15 am
    Mitochondria-derived DAMPs and Fibrosis
    Yury Popov, MD, PhD
  • 8:15-8:30 am
    Hepatic Stellate Cell-derived Hyaluronic Acid Drives Stellate Cell Activation and Fibrosis
    Ekihiro Seki, MD, PhD
  • 8:30-8:45 am
    Neutrophil-derived DAMPs in NASH Progression
    Allan Tsung, MD
  • 8:45-9 am
    Redox-dependent Regulation of Hepatocyte AIM2 Inflammasome Activation in Sterile Liver Injury in Mice
    Melanie Scott, MD, PhD
  • 9-9:20 am
    Discussion
  • 9:20-9:30 am
    Break

Session II: HMGB1, A Critical DAMP in Liver Disease

  • 9:30-9:45 am
    Endotoxin Sensing by the Liver Parenchyma: A Mechanism for Systemic HMGB1 Release
    Timothy R. Billiar, MD
  • 9:45-10 am
    Role of the HMGB1 Post-translational Modifications and Signaling via the Receptor for Advanced Glycation End-products in Liver Fibrosis
    Harriett Gaskell, PhD
  • 10-10:15 am
    Identification of A Receptor-mediated HMGB1 Pro-inflammatory Loop in Alcoholic Liver Disease
    Natalia Nieto, PhD
  • 10:15-10:30 am
    HMGB1-induced Receptor Signaling in Acetaminophen-induced Liver Injury
    Daniel J. Antoine, PhD
  • 10:30-10:50 am
    Discussion
  • 10:50-11 am
    Break

Session III: Novel Signaling Pathways in Liver Disease

  • 11-11:15 am
    The IRAKM-Mincle Axis Links Cell Death to Inflammation: Pathophysiological Implications for Alcoholic Liver Disease
    Xiaoxia Li, PhD
  • 11:15-11:30 am
    Spontaneous Hepatocellular Carcinoma After the Combined Deletion of Akt Isoforms
    Nissim Hay, PhD
  • 11:30-11:45 am
    Hippo Signaling Interactions with Wnt/β-catenin and Notch Signaling Repress Liver Tumorigenesis
    Yingzi Yang, PhD
  • 11:45 am-Noon
    Discussion