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The AASLD Liver Meeting 2017, Washington DC, October 20-24

Monday, November 16

Poster Session III
8:00 am - 5:30 pm
Presenters in attendance 12:30 pm - 2:00 pm

Adaptive and Innate Immunology
Alcohol: Clinical and Experimental
Basic Fibrosis Research
Clinical and Translational Fibrosis Research
Cost-Effectiveness and Economics of Care
Encephalopathy and Other Complications of Cirrhosis
Experimental Studies in Cirrhosis and Portal Hypertension
Health Economics and Cost Effectiveness of Viral Hepatitis
Hepatitis B: Epidemiology and Natural History
Hepatitis B: Virology, Immunology, and Pathogenesis
Pediatric Liver Disease
Viral Hepatitis in Liver Transplant

Late-breaking posters

 

Adaptive and Innate Immunology

1282 Mincle Signaling Exacerbates Autoimmune Hepatitis
Alejandro Torres Hernandez, Stephanie Greco, S. Rae Rokosh, Lena Tomkoetter, Donnele Daley, Muhammad Atif Salyana, Aleksandr Kalabin, Gregor Werba, George Miller
New York University School of Medicine

1283 Macrophage Specific ß-catenin Controls Innate Immunity by Regulating IAP-JNK Axis in Liver Inflammatory Injury
Shi Yue1, Changyong Li1, Xingliang Zhou2, Ronald W. Busuttil1, Qilong Ying2, Jerzy Kupiec-Weglinski1, Bibo Ke1
1The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, 2Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC

1284 The long noncoding RNA VL30-1 is a key regulator of liver injury via enhancement of HIF1a mediated inflammation
Xinshou Ouyang, Sheng-Na Han, Irma Garcia-Martinez, Luke Cai, Richard A. Flavell, Wajahat Z. Mehal
Yale University

1285 Galectin-3 mediates NLRP3 inflammasome signaling and contributes to pathogenesis of primary biliary cirrhosis
Jijing Tian1, 2, Guo-Xiang Yang1, Fu-Tong Liu1, M. Eric Gershwin1, Natalie J. Torok1, Joy Jiang1
1UCDMC, 2Chinese Academy of Sciences, Beijing, China

1286 Kupffer cells signature in alcoholic steatohepatitis in mice encompasses loss of signalling/ chaperone and enrichment of cytoskeleton proteins in the lipid rafts
Angela Dolganiuc1, Tracie Lo2
1University of Florida, 2New York Medical College

1287 IL28B genetic variants determine the extent of monocyte-induced activation of NK cells in hepatitis C
Benjamin Krämer1, Beatriz . Sastre Turrión2, Claudia Finnemann1, Philipp Lutz1, Andreas Glässner1, Franziska Wolter1, Pavlos Kokordelis1, Dominik J. Kaczmarek1, Felix Goeser1, Christian P. Strassburg1, Ulrich Spengler1, Jacob Nattermann1
1Univeritiy of Bonn, 2Hospital Ramón y Cajal - IRYCIS

1288 High baseline expression of type 1 interferon (IFN)-inducible genes involved in cell-autonomous immunity predicts mortality in patients with decompensated alcoholic cirrhosis
Marc Pineton de Chambrun1, Emmanuel Weiss1, Pierre-Emmanuel Rautou2, Magali Fasseu1, Mikhael Giabicani1, Rakhi Maiwall3, Dominique C. Valla2, 1, Didier Lebrec2, 1, Francois Durand2, 1, Pierre de la Grange4, Sophie Lotersztajn1, 2, Richard Moreau1, 2
1Inserm and Paris Diderot University, 2Hôpital Beaujon, 3Institute of Liver and Biliary Science, 4Genosplice

1289 Proportion of Intrahepatic CD56Bright Natural Killer Cells Correlates with Well-preserved Liver Function
Erin H. Doyle1, Adeeb Rahman2, Arielle L. Klepper1, Sang Kim3, Brandy M. Haydel4, Sander S. Florman5, M. Isabel Fiel6, Thomas D. Schiano5, Andrea D. Branch1
1Icahn School of Medicine at Mount Sinai, 2Icahn School of Medicine at Mount Sinai, 3The Mount Sinai Hospital, 4Icahn School of Medicine at Mount Sinai, 5The Mount Sinai Hospital, 6The Mount Sinai Hospital

1290 Activation of hepatic innate immunity markedly alters the IL-22/IL-22R1/IL-22BP axis within the liver: Implications for hepatic immunity.
Wagdi Almishri, Julie Deans, Mark Swain
University of Calgary

1291 Impaired TRAF6 methylation and TLR responses in liver tissue and circulating monocytes from patients with spontaneous bacterial peritonitis
Irina Tikhanovich, Jody C. Olson, Ryan Taylor, Brian Bridges, Kenneth Dorko, Benjamin R. Roberts, Steven A. Weinman
University of Kansas Medical Center

1292 Implants of matrix-embedded endothelial cells rescue ischemic tissue and liver engraftment in hepatectomized mice
Pedro Melgar-Lesmes1, Mercedes Balcells2, 1, Elazer R. Edelman1, 3
1Massachusetts Institute of Technology, Cambridge, MA, USA, 2Institut Químic de Sarrià, Ramon Llull Univ, 3Brigham and Women’s Hospital, Harvard Medical School

1293 Identification of liver monocytic myeloid-derived suppressor cells and elucidation of their roles in non-alcoholic fatty liver disease
Liying Yao, Masanori Abe, Teruki Miyake, Yoshiko Nakamura, Yusuke Imai, Yohei Koizumi, Takao Watanabe, Osamu Yoshida, Masashi Hirooka, Yoshio Tokumoto, Bunzo Matsuura, Yoichi Hiasa
Ehime Universiy Graduate School of Medicine

1294 Chronic alcohol consumption skews hepatic dendritic cell homeostasis and reveals a novel potential cellular source of TNFa
Holger Fey, Costica Aloman
University of Illinois at Chicago

1295 Effects of myeloid cell-selective deficiency of IL-6 for liver regeneration after partial hepatectomy (PH) in mice.
Carolina Fernandez Mena1, Jorge Almagro1, Marta Puerto1, 2, Albert Quintana3, Juan Hidalgo3, Rafael Bañares1, 2, Javier Vaquero1, 2
1Hospital General Universitario Gregorio Marañón - IiSGM, 2CIBERehd, 3Instituto de Neurociencias - Universidad Autónoma de Barcelona

1296 Intracellular crawling of lymphocytes through hepatic sinusoidal endothelial cells - a novel step in the adhesion cascade?
Shishir Shetty, Daniel A. Patten, Chris J. Weston, David H. Adams
University of Birmingham

1297 Inhibition of the FGL2:Fc?RIIB Immunosuppressive Pathway Restores Antiviral T and B Cell Responses During Chronic Viral Infection
Ramzi Khattar, Olga Luft, Kaveh Farrokhi, Vanessa Rojas Luengas, Hassan Sadozai, Gary Levy, Nazia Selzner
University Health Network

1298 MAIT cells are enriched in portal tracts and respond to biliary epithelial cells presenting bacterial ligands during liver inflammation
Hannah C. Jeffery1, Bonnie Van Wilgenburg3, Kathryn Stirling1, Krishan Parekh1, Sheree Roberts1, Ayako Kurioka3, Stuart Hunter1, David H. Adams1, 2, Paul Klenerman3, Ye H. Oo1, 2
1University of Bimringham, 2University of Birmingham NHS Foundation Trust, 3University of Oxford

1299 Alterations in liver dendritic cell subtypes during non-alcoholic steatohepatitis
Eva-Carina Heier, Hannes Borchardt, Henrike Julich, Christoph Eckert, Niklas Klein, Thomas Tschernig, Veronika Lukacs-Kornek
Saarland University

1300 Soluble CD163 plasma concentration is related with necroinflammatory activity and liver function impairment in compensated cirrhotic patients and is not related with bacterial translocation
Francesco Figorilli2, 1, Karen Louise Thomsen2, Jane MacNaughtan2, I. Jane Cox3, Alba Moratalla4, Isidora Ranchal2, Holger J. Møller5, Rajeshwar Mookerjee2, Nathan Davies2, Rajiv Jalan 2
1Universita' di Cagliari, 2UCL Medical School, Royal Free Campus, 3nstitute of Hepatology, London, Foundation for Liver Research, 69-75 Chenies Mews, 4Hospital General Universitario de Alicante, CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), 5Aarhus University Hospital

1301 Hepatitis B X-interacting protein (HBXIP) negatively regulates IFN-ß production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
Hang Zhang
Hangzhou Normal University

Alcohol: Clinical and Experimental

1302 Toll-like receptor 9 and B-cell activating factor signals induce impaired immunological memory in cirrhosis.
Hiroyoshi Doi1, David E. Kaplan3, Eiichi Hayashi1, Jun Arai1, Risa Omori1, Manabu Uchikoshi1, Kenichi Morikawa4, Junichi Eguchi2, Takayoshi Ito2, Hitoshi Yoshida1
1Showa University, 2Showa University Koto Toyosu Hospital, 3University of Pennsylvania, 4Hokkaido University

1303 Low Dose Zinc Sulfate (220mg) Supplementation for Three Months Normalizes Zinc Levels, Endotoxeima, Pro-Inflammatory/Fibrotic Biomarkers & Improves Clinical Parameters in Alcoholic Cirrhosis– A Double-Blind Placebo Controlled – (ZAC) Clinical Trial
Mohammad K. Mohammad1, 2, Keith C. Falkner1, Ming Song1, Craig J. McClain1, 2, Matthew C. Cave1, 2
1university of louisville, 2Robely Rex Veteran Hospital

1304 Acrolein, a lipid-derived aldehyde, is a critical pathogenic mediator and potential therapeutic target for alcoholic liver disease
Wei-Yang Chen1, Jingwen Zhang1, Shirish Barve1, Craig J. McClain1, 2, Swati Joshi-Barve1
1University of Louisville, 2Robley Rex VAMC

1305 Intestinal HIF-1a Deletion Exacerbates Alcohol-induced Hepatic Steatosis Mediated by Intestinal Dysbiosis and Barrier Dysfunction
Tuo Shao1, Liming Liu1, Fengyuan Li1, Lihua Zhang1, Craig J. McClain1, 2, Wenke Feng1
1University of Louisville, 2Robley Rex VAMC

1306 Fibroblast growth factor 21 is critically involved in alcohol-induced hepatic lipid metabolism and adipose tissue lipolysis in mice
Cuiqing Zhao1, Liming Liu1, Ying Yang1, Craig J. McClain1, 2, Wenke Feng1
1University of Louisville, 2Robley Rex VAMC

1307 Early prediction of response in patients with severe acute alcoholic hepatitis by using Lille model on day 4
Mauricio Garcia-Saenz de Sicilia1, Chitharanjan Duvoor2, José T. Altamirano4, 5, Veronica Prado3, 4, Juan Caballeria3, 4, Andres Duarte-Rojo1
1University of Arkansas for Medical Sciences, 2University of Arkansas for Medical Sciences, 3Liver Unit, Hospital Clinic, 4Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), 5Vall d’Hebron Institut de Recerca

1308 Ethanol-impairs mTOR activity by a novel non-canonical PI3K?-PP2A axis activating skeletal muscle autophagy that underlies sarcopenia.
Gangarao Davuluri2, Samjhana Thapaliya2, Avinash Kumar2, Megan R. McMullen2, Rebecca L. McCullough2, Laura E. Nagy2, Sathyamangla V. Naga Prasad3, Srinivasan Dasarathy1
1Cleveland Clinic, 2Cleveland Clinic, 3Cleveland Clinic

1309 Differential Changes In Pro-Apoptotic Plasma Glycochenodeoxycholate And Fecal Glycodeoxycholate Characterize Bile Acid Metabolome In Alcoholic Liver Disease
Puneet Puri2, Andrew R. Joyce1, Amon Asgharpour2, Mohammad S. Siddiqui2, Richard K. Sterling2, R. Todd Stravitz 2, Velimir A. Luketic2, Scott C. Matherly2, Kalyani Daita2, Susan A. Walker2, Stephanie Taylor2, Christian E. Ammons2, Faridoddin Mirshahi2, Arun J. Sanyal2
1Venebio, 2Virginia Commonwealth University

1310 Ethanol Exposure Inhibits Hepatocellular Lipophagy by Inactivating the Small Regulatory GTPase Rab7
Ryan J. Schulze1, Shaun Weller1, Micah B. Schott1, Karuna Rasineni2, Barbara Schroeder1, Carol A. Casey2, Mark A. McNiven1
1Mayo Clinic, 2University of Nebraska Medical Center

1311 Alcohol modifies the composition of the intrahepatic macrophage pool through FOXO3-dependent and cell type specific apoptosis
Zhuan Li, Jie Zhao, Steven A. Weinman
University of Kansas Medical Center

1312 PDE4 inhibition attenuates alcohol induced hepatic oxidative stress by increasing antioxidant enzyme expression
Diana Avila1, Jingwen Zhang1, Craig J. McClain1, 2, Shirish Barve1, Leila Gobejishvili1
1University of Louisville, 2Robley Rex VAMC

1313 Hepatocyte-specific deletion of the essential circadian clock transcription factor BMAL1 enhances chronic ethanol-induced depletion of hepatic glycogen in mice
Uduak S. Udoh, Telisha Swain, Shannon Bailey
University of Alabama at Birmingham

1314 Ceramide Synthase May Regulate Hepatic Perilipin 2 and Lipid Metabolism in Experimental Alcoholic Steatosis
Bianca Williams, Jason Correnti, Rotonya M. Carr
University of Pennsylvania

1315 Alcohol stimulates macrophage activation through caspase dependent hepatocyte derived release of CD40L containing extracellular vesicles
Vikas K. Verma1, Haiyang Li1, 4, Ruisi Wang1, Petra Hirsova1, Sheng Cao1, Harmeet Malhi1, Patricia C. Contreras3, Patrick S. Kamath1, Gregory J. Gores1, Vijay Shah1, 2
1Mayo Clinic, 2TREAT Consortium, 3Conatus Pharmaceuticals, 4Affiliated Hospital of Guiyang Medical College

1316 Coffee Consumption Protects Against and Caucasian Race Increases Risk of Alcoholic Hepatitis Among Heavy Drinkers
Ashwani K. Singal2, Puneet Puri3, Suthat Liangpunsakul4, Andrew Borst4, Arun J. Sanyal3, Naga P. Chalasani4, Barry P. Katz4, Zhangsheng Yu4, Xiaowei Ren4, Patrick S. Kamath1, Vijay Shah1
1Mayo Clinic, 2University of Alabama Birmingham, 3Virginia Commonwealth University, 4Indiana University

1317 Interplay between microRNA-21 and TGF-beta signaling regulates mesenchymal phenotypes in alcoholic liver injury
Tami Annable1, 2, Kelly McDaniel2, 1, Yuyan Han3, 2, Julie Venter3, 2, Ying Wan1, 2, Lindsey Kennedy2, Nan Wu3, 2, Tina Kyritsi3, 2, Tianhao Zhou3, 2, Jessica S. Garner1, Heather L. Francis1, 2, Shannon S. Glaser3, 2, Gianfranco Alpini3, 2, Fanyin Meng1, 2
1Scott & White Hospital, Texas A&M HSC College of Medicine, 2Central Texas Veterans Healthcare System, 3Texas A&M HSC College of Medicine

1318 Increased IL-17 production in Paneth cells of the small intestinal crypts is an early indicator of steatohepatitis in an acute-on-chronic alcohol model in mice
Benedek Gyongyosi, Patrick Lowe, Arvin Iracheta-Vellve, Abhishek Satishchandran, Aditya Ambade, Banishree Saha, Gyongyi Szabo
UMass Medical School

1319 Microbiota protects mice against acute alcohol-induced liver injury
Peng Chen, Yukiko Miyamoto, Magdalena Mazagova, Lars Eckmann, Bernd Schnabl
University of California San Diego

1320 Hepatocyte-specific StARD1 deletion attenuates alcoholic steatohepatitis
Vicent Ribas1, 2, Susana Nuñez2, 1, Carmen Garcia-Ruiz2, 1, Jose Fernandez-Checa 2, 1
1Hospital Clínic i Provincial de Barcelona, IDIBAPS, 2Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC))

1321 Infection in alcoholic hepatitis: a major prognostic indicator and potential therapeutic target
Richard Parker1, 4, Fiona Jones2, Daniel J. Wheatley3, Ian A. Rowe1, Christopher Corbett3, Andrew Holt4, Stephen Stewart2
1University of Birmingham, 2Mater Misericordiae University Hospital, 3New Cross Hospital, 4University Hospitals Birmingham NHS Foundation Trust

1322 Nogo-B facilitates M1 polarization of Kupffer cells and contributes to the pathogenesis of alcohol liver disease in humans and mice
Jin-Kyu Park1, Moon Young Kim1, 2, Soon Koo Baik2, Mee-Yon Cho3, Teruo Utsumi1, Yasuko Iwakiri1
1Yale University School of Medicine, 2Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, 3Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine

1323 Ethanol-Induced Alterations In The Intestinal Methionine Metabolic Pathway Promote Tight Junction Disruption.
Dan Feng1, 2, Paul G. Thomes3, Natalia A. Osna1, 2, Dean J. Tuma1, 2, Kusum K. Kharbanda1, 2
1Veterans Affairs Nebraska-Western Iowa Health Care System, 2University of Nebraska Medical Center, 3Cannon Research Center, Carolinas Healthcare System

1324 Role of Pre-mRNA Splicing Regulator SLU7 in Mediating Detrimental Action of Ethanol in the Liver
Jiayou Wang1, 2, Xudong Hu1, 3, Alvin Jogasuria1, Kwangwon Lee1, Jiashin Wu1, Min You1
1Northeast Ohio Medical University (NEOMED), 2Guangzhou University of Chinese Medicine, 3Shanghai University of Traditional Chinese Medicine

1325 Impaired Proteasome Function is Associated with Alcohol-Induced Hepatic Receptor Interacting Protein 3-Mediated Necroptosis, Steatosis and Liver Injury
Wen-Xing Ding, Shaogui Wang, Hong-Min Ni
The University of Kansas Medical Center

1326 Characteristic features of microbiomes in alcoholic liver disease analyzed by 16S ribosomal RNA gene pyrosequencing and transcriptional fragment length polymorphism methods using fecal samples: the impact of abstinence
Makiko Taniai, Etsuko Hashimoto, Kuniko Yamamoto, Yuichi Ikarashi, Kazuhisa Kodama, Tomomi Kogiso, Nobuyuki Torii, Katsutoshi Tokushige
Tokyo Women's Medical University

1327 LPS-TLR4 pathway mediates ductular reaction expansion in alcoholic hepatitis
Gemma Odena1, Raluca Dumitru2, Jiegen Chen1, José T. Altamirano3, 4, Veronica L. Massey1, Hiroshi Matsushita5, Daniel Rodrigo-Torres3, Oriol Morales-Ibanez3, Juan Caballeria6, 3, Pere Gines6, 3, Ekihiro Seki5, Pau Sancho-Bru3, Ramon Bataller1, 3
1University of North Carolina at Chapel Hill, 2University of North Carolina at Chapel Hill, 3Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBER de Enfermedades Hepaticas y Digestivas (CIBERehd), 4Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca, 5Cedars-Sinai Medical Center, 6Hospital Clínic

1328 Positive familial metabolic traits predispose and increase severity of alcoholic cirrhosis
Ajeet S. Bhadoria2, Chandan K. Kedarisetty1, Ankit Bhardwaj2, Guresh Kumar2, Tanmay S. Vyas1, Jaya Benjamin3, Varsha Shasthry3, Manoj Kumar1, Shiv K. Sarin1
1Institute of Liver and Biliary Sciences, 2Institute of Liver and Biliary Sciences, 3Institute of Liver and Biliary Sciences

1329 The Epidemiology and Costs of Alcoholic Cirrhosis in the United States. A Review of 50,567 Admissions from the 2012 National Inpatient Sample.
Jennifer Saad1, Neil Volk1, Shawn Shah1, Joseph Shatzel1, Harley Friedman1, Rolland C. Dickson2
1Dartmouth Hitchcock Medical Center, 2Dartmouth Hitchcock Medical Center

1330 Gut Bacterial Load Influences Neutrophil Infiltration And Liver Inflammation In An Acute-On-Chronic Alcohol Feeding Model In Mice
Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Gyongyi Szabo
UMass Medical School

1331 Tributyrin, a butyrate pro-drug, attenuates alcohol-induced inflammation and neutrophil-mediated hepatic injury
Hridgandh Donde1, Smita Ghare1, Jingwen Zhang1, Swati Joshi-Barve1, Craig J. McClain1, 2, Shirish Barve1
1University of Louisville, 2Robley Rex VAMC

1332 Differential microRNA expression profiles in patients with alcoholic hepatitis (AH): Preliminary findings from the Translational Research and Evolving Alcoholic Hepatitis Treatment (TREAT) consortium
Suthat Liangpunsakul1, Naga P. Chalasani1, Guanglong Jiang2, Yunlong Liu2, Vijay Shah3, Arun J. Sanyal4, Svetlana Radaeva5, David W. Crabb1
1Indiana University School of Medicine, 2Center for Computational Biology and Bioinformatics, Indiana University, 3Mayo Clinic College of Medicine, 4Virginia Commonwealth University, 5NIH/NIAAA

1333 Oral pentamidine (VLX103) prevents the development of alcoholic liver disease in mice
Ghulam Ilyas1, Enpeng Zhao1, Kathryn Tanaka3, Francois Ravenelle2, Mark J. Czaja1
1Albert Einstein College of Medicine, 2Verlyx Pharma Inc, 3Albert Einstein College of Medicine

1334 Inflammatory and apoptotic markers in alcoholic hepatitis patients: interim analyses
Leila Gobejishvili1, Vatsalya Vatsalya1, Mohammad K. Mohammad1, Shirish Barve1, Craig J. McClain1, 2
1University of Louisville, 2Robley Rex VAMC

1335 Zinc deficency inactivate hepatic mitochondrial biogensis pathway in rats chronically fed alcohol: A mechanism of perturbed hepatic mitochondrial respiratory complexes and ROS generation
Qian Sun, Wei Zhong, Wenliang Zhang, Zhanxiang Zhou
University of North Carolina at greensboro

1336 Nuclear receptor Rev-Erba functions as a transcriptional activator of Chop to control SHP mediated alcoholic fatty liver
Zhihong Yang1, Hiroyuki Tsuchiya2, Sangmin Lee1, Yuxia Zhang3, Li Wang1
1university of Connecticut, 2university of Utah, 3University of Kansas Medical Center

1337 The Alcoholic Hepatitis Histology Score Performs Poorly in a Cohort of Severe Alcoholic Hepatitis in the United States
Gene Y. Im1, Aparna Goel1, Stephen C. Ward2, Yujin Hoshida1, Thomas D. Schiano1, Scott L. Friedman1, Swan N. Thung2
1Icahn School of Medicine at Mount Sinai, 2Icahn School of Medicine

1338 Genetic Ablation of MitoNEET Alleviates Alcoholic Steatosis/Steahepatitis in Mice
Alvin Jogasuria1, Werner J. Geldenhuys1, Jiayou Wang1, 2, Xudong Hu1, 3, Kwangwon Lee1, Prabodh Sadana1, Jiashin Wu1, Min You1
1Northeast Ohio Medical University (NEOMED), 2Guangzhou University of Chinese Medicine, 3Shanghai University of Traditional Chinese Medicine

1339 Cross talk between hepatocytes and macrophages in Alcoholic Liver Disease: which language do they use?
Veronica Marin1, Kyle L. Poulsen2, Laura E. Nagy2, 3, Claudio Tiribelli1, 4, Natalia Rosso1
1Fondazione Italiana Fegato, 2Cleveland Clinic, 3Case Western Reserve University, 4University of Trieste

1340 Sarcopenia and adipopenia set in with cirrhotic decompensation in patients with alcoholic liver disease
Varsha Shasthry1, Jaya Benjamin1, Chethan Kalal2, Lovkesh Anand2, Ankit Bhardwaj2, Vanshja Pandit1, Ankur Arora3, S. Rajesh3, Viniyendra Pamecha4, Vikas Jain5, Guresh Kumar6, Y.K Joshi1, Shiv K. Sarin2, Puneet Puri7
1Institute of liver and biliary sciences, 2Institution of liver and biliary sciences, 3Institution of liver and biliary sciences, 4Institute of liver and biliary sciences, 5Institution of liver and biliary sciences, 6Institution of liver and biliary sciences, 7University of Virginia

1341 The role of proinflammatory cytokines, adipokines and lipid peroxidation in short term mortality in patients with Severe Alcoholic Hepatitis.
Onan Perez-Hernandez1, 2, Geraldine del Carmen Quintero-Platt1, Carlos Jorge-Ripper1, 2, Camino Maria Fernandez-Rodriguez1, 2, Maria Blanca Monereo Muñoz1, Maria Jose Sanchez-Perez1, Emilio Gonzalez-Reimers1, 2, Ruben Hernandez-Luis1, 2
1Hospital Universitario de Canarias, 2Universidad de La Laguna

1342 Nosocomial Infection in Severe Alcoholic Hepatitis
Onan Perez-Hernandez1, 2, Geraldine del Carmen Quintero-Platt1, Emilio Gonzalez-Reimers1, 2, Maria Jose Sanchez-Perez1, Pedro Abreu-Gonzalez3, Maria Jose de la Vega-Prieto4, Carlos Jorge-Ripper1, 2, Francisco Santolaria-Fernandez1, 2
1Hospital Universitario de Canarias, 2Universidad de la Laguna, 3Universidad de La Laguna, 4Hospital Universitario de Canarias

1343 Effects of Alcohol and Abstinence on Liver Stiffness as measured by Transient Elastography
Izabella Pokorski1, Yang Wu2, Martin Weltman2, Guy D. Eslick3
1Nepean Blue Mountains Local Health District , 2Nepean Hospital , 3The University of Sydney

1344 Microparticles Are Markers Of Immune Cell Stress And Predict Severity And Outcomes In Patients With Alcoholic Liver Disease
Sukriti Sukriti1, Jaswinder S. Maras1, Shvetank Sharma1, Madhumita Premkumar2, Sukanta Das1, Shabir Hussain1, Guresh Kumar1, Naminita Gogoi3, Ashok K. Choudhury2, Chinmay Mukhopadhyay3, Nirupma Trehanpati1, Shiv K. Sarin1, 2
1Institute of Liver and Biliary Sciences, 2Institute of Liver and Biliary Sciences, 3JNU

1345 An alarmin cytokine IL-33 inhibits type I NKT cells and neutrophil accumulation into liver and mediates attenuation of alcoholic liver disease
Igor Maricic, Ekihiro Seki, Idania Marrero, Vipin Kumar
University of California

1346 Macrophage Migration Inhibitory Factor is Protective in a Model of Chronic-Binge Ethanol Feeding in Mice
Kyle L. Poulsen3, Natalia Rosso1, Veronica Marin1, Megan R. McMullen3, Adam R. Morris3, Claudio Tiribelli1, 2, Laura E. Nagy3, 4
1Italian Liver Foundation - Liver Research Center, 2Universita degli Studi di Trieste, 3Center for Liver Disease Research - Cleveland Clinic Foundation, 4Center for Liver Disease Research - Cleveland Clinic Foundation

1347 Creatine Supplementation Does Not Prevent Alcoholic Steatosis.
Dan Feng1, 2, Ryan W. Barton2, Paul G. Thomes3, Dean J. Tuma1, 2, Natalia A. Osna1, 2, Kusum K. Kharbanda1, 2
1Veterans Affairs Nebraska-Western Iowa Health Care System, 2university Nebraska Medical Center, 3Cannon Research Center, Carolinas Healthcare System

1348 The L-carnitine alleviate hepatic fibrosis in a non-alcoholic steatohepatitis
Hajime Sunagozaka1, Masao Honda1, Taro Yamashita1, Hikari Okada1, Naoki Oishi1, Tetsuro Shimakami1, Kazuya Kitamura1, Kuniaki Arai1, Yoshio Sakai1, Tatsuya Yamashita1, Naoto Nagata2, Toshinari Takamura2, Eishiro Mizukoshi1, Shuichi Kaneko1
1kanazawa university Hospital, 2 Kanazawa University Graduate School of Medical Sciences

1349 Functional role of the Lin28/let-7 system during alcoholic liver injury
Kelly McDaniel2, 1, Tami Annable2, 1, Yuyan Han3, 2, Tianhao Zhou3, 2, Julie Venter3, 2, Ying Wan1, 2, Jessica S. Garner1, Nan Wu3, 2, Shannon S. Glaser3, 2, Heather L. Francis1, 2, Gianfranco Alpini3, 2, Fanyin Meng1, 2
1Scott & White Hospital, Texas A&M HSC College of Medicine, 2Central Texas Veterans Healthcare System, 3Texas A&M HSC College of Medicine

1350 Elevated leukocyte count combined with radiologic evidence of a nodular liver surface in uninfected patients strongly predicts histologic alcoholic hepatitis, obviating the need for liver biopsy
Nitzan Roth1, Behnam Saberi 2, Jared Macklin3, John Donovan1, Andrew Stolz1, Gary C. Kanel4, Neil Kaplowitz1
1University of Southern California, 2The Johns Hopkins University, 3University of Southern California, 4University of Southern California

1351 Molecular chaperone Hsp90 regulates cell-specific induction of epigenetic genes important in macrophage activation and lipid metabolism during alcoholic liver injury
Pranoti Mandrekar, Aditya Ambade, Arlene Lim
University of Massachusetts Medical School

1352 Cyr61 protection of hepatocytes from alcohol-induced endoplasmic reticulum stress
Sang Geon Kim, Tae Hyun Kim, Hyun Joo Kim
Seoul National University

Basic Fibrosis Research

1353 IL-13Ra1 signaling and M2 macrophages but not Th2 T cells drive progression of CCL4-induce fibrosis
Shih-Yen Weng1, Xiaoyu Wang1, Yong Ook Kim1, Leonard Kaps1, Yilang Tang2, Olena Molokanova1, Jeff R. Crosby3, Michael L. McCaleb3, Brombacher Frank4, Tobias Bopp5, Hans-Joerg Schild5, Ari Waisman2, Detlef Schuppan1, 6
1Institute of Translational Immunology, University Medicine, Johannes Gutenberg University, Mainz, Germany, 2Institute for Molecular Medicine, 3Isis Pharmaceuticals, 4Institute of Infectious Disease and Molecular Medicine, 5Institute of Immunology and Research Center for Immunotherapy at UMC Mainz, 6Beth Israel Deaconess Medical Center

1354 Myofibroblastic conversion of portal fibroblasts and mesothelial cells isolated from adult mouse liver
Ingrid A. Lua, Kinji Asahina
Department of Pathology, Keck Scool of Medicine

1355 Selective disruption of dynamin GTPase activity in HSC increases murine fibrogenesis in vivo and promotes HSC activation in vitro
Qian Ding1, Ruisi Wang1, Thiago de Assuncao1, Meng Yin2, Sheng Cao1, Usman Yaqoob1, Richard Ehman2, Robert C. Huebert1, Vijay Shah1
1Mayo Clinic, 2Mayo Clinic

1356 Binding of hepatic stellate cell (HSC)-secreted exosomes to HSC is heparin- and integrin-dependent
Li Chen1, Ruju Chen1, Sherri Kemper1, David Brigstock1, 2
1Nationwide Childrens Hospital, 2The Ohio State University

1357 Potential of connective tissue growth factor as a novel therapeutic target against hepatic fibrosis
Yuki Makino, Hayato Hikita, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
Osaka University Graduate School of Medicine

1358 Exosome-mediated activation of TLR3 in stellate cells stimulates IL-17A production of ?d T cells in liver fibrosis of mice
Wonhyo Seo, Hyuk-Soo Eun, So Yeon Kim, Seol-Hee Park, Jong-Min Jeong, Won-Mook Choi, Myung-Ho Kim, Won-IL Jeong
KAIST

1359 Efficacy of an ASK1 Inhibitor to Reduce Fibrosis and Steatosis in a Murine Model of NASH is Associated with Normalization of Lipids and Hepatic Gene Expression and a Reduction in Serum Biomarkers of Inflammation and Fibrosis
Satyajit Karnik1, Michael R. Charlton2, Li Li1, Michelle Nash1, Maisoun Sulfab1, David Newstrom1, Erik G. Huntzicker1, Dorothy French1, Zachary D. Goodman3, Tracy Shafizadeh4, Steve Watkins4, David Breckenridge1, Daniel Tumas1
1Gilead Sciences, 2Mayo Clinic, 3Inova Fairfax Hospital, 4Metabolon Inc

1360 Endothelial Niche Derived Notch Signaling Pathway Balanced Liver Regeneration and Fibrosis in Distinct Ways
Lin Wang
Fourth Military Medical University

1361 Liver fatty acid-binding protein is required for Perilipin 5 to restore lipid droplets in activated hepatic stellate cells
Jianguo Lin1, Elizabeth P. Newberry2, Nicholas O. Davidson2, Anping Chen1
1Saint Louis University, 2Washington University in St. Louis

1362 Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury
Katharine Irvine1, Andrew D. Clouston1, Antje Blumenthal3, Elizabeth E. Powell1, 2
1The University of Queensland, 2Princess Alexandra Hospital, 3The University of Queensland

1363 Mast cells interact with proliferating cholangiocytes to activate hepatic stellate cells and promote fibrosis via TGF-ß1 signaling during cholestatic injury
Lindsey Kennedy2, Laura Hargrove1, Jennifer Owens2, Heather L. Francis2, 1
1Scott and White Memorial Hospital, 2Central Texas Veteran's Health Care System

1364 Hepatocyte autophagy impairment promotes ductular reaction and fibrogenesis by hepatic stellate cells
Youngmin A. Lee1, Luke A. Noon1, 2, Tingfang Lee1, Marie-Luise Berres3, 7, Fatemeh P. Parvin-Nejad1, Kemal M. Akat4, Hsin I Chou1, Varinder Athwal1, 8, M. Isabel Fiel5, Ronald E. Gordon6, Scott L. Friedman1
1Icahn School of Medicine at Mount Sinai, 2Centro de Investigación Principe Felipe (CIPF), 3University Hospital, RWTH Aachen, 4HHMI/Rockefeller University, 5Icahn School of Medicine at Mount Sinai, 6Icahn School of Medicine at Mount Sinai, 7Icahn School of Medicine at Mount Sinai, 8University of Manchester

1365 Hepatocyte- and hepatic stellate cell-specific deletion of liver fatty acid binding protein (L-Fabp) reveals divergent, cell-type specific roles in hepatic lipid trafficking and fibrogenesis.
Elizabeth P. Newberry1, Susan M. Kennedy1, Gianfranco Alpini3, Anping Chen2, Nicholas O. Davidson1
1Washington University School of Medicine, 2St. Louis University, 3Central Texas Veterans Health Care System and Texas A&M HSC College of Medicine

1366 Fibrous network composition and cell heterogeneity modulate long-range force transmission by cells in matrices
Robert N. Kent, Jude D. Han, Rebecca G. Wells
University of Pennsylvania

1367 Dual combination therapy directed against lysyl oxidase-like 2 (LOXL2) and apoptosis signal-regulating kinase 1 (ASK1) potently inhibits fibrosis and portal hypertension in a new mouse model of PSC-like liver disease
Naoki Ikenaga1, Susan B. Liu1, Zhen-Wei Peng1, Andrew E. Greenstein2, Dorothy French2, Victoria Smith2, Yury Popov1
1Beth Israel Deaconnes , 2Gilead Sciences, Inc

1368 Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis and tumorigenesis
Zhen-Wei Peng1, 3, Naoki Ikenaga1, Susan B. Liu1, Deanna Sverdlov1, Paul Weinreb2, Shelia Violette2, Dean Sheppard4, Detlef Schuppan1, Yury Popov1
1Beth Israel Deaconess Medical Center, 2Biogen Idec, Inc, 3The First Affiliated Hospital of Sun Yat-sen University, 4University of California, San Francisco School of Medicine

1369 Opioid Growth Factor Receptor-Like 1; a Novel Bone Marrow Cells-Derived Factor That Accelerates Regeneration of Murine Fibrotic Liver
Takayo Yanagawa1, 5, Hideaki Sumiyoshi1, 5, Sachie Nakao1, 5, Masato Ohtsuka2, Minoru Kimura2, Yousuke Chiba1, 3, Shintaro Satake1, 3, Tadashi Moro1, 4, Hiromi Chikada2, Akihide Kamiya2, Yutaka Inagaki1, 5
1Tokai University School of Medicine, 2Tokai University School of Medicine, 3Tokai University Scool of Engeneering, 4Minophagen Pharmaceutical Co. Ltd., 5Tokai University Graduate School of Medicine

1370 Interleukin 15 regulates transforming growth factor ß1-induced collagen production in hepatic stellate cells by controlling a network of suppressors of collagen transcription
Kohtaro Ooka3, Huanzi Han1, Holger Fey1, Costica Aloman1, Jingjing Jiao2
1University of Illinois at Chicago, 2University of Texas MD Anderson Cancer Center, 3University of Illinois at Chicago

1371 NLRP3 inflammasome modulation of hepatic stellate cell activation: role in liver fibrosis
Alexander Wree1, 2, Matthew D. McGeough1, Davide Povero1, Akiko Eguchi1, Hal M. Hoffman1, Ariel E. Feldstein1
1UCSD, 2University Hospital, RWTH-Aachen

1373 The paracrine effect of hepatocellular carcinoma (HCC) on adenosine monophosphate activated kinase (AMPK) in human hepatic stellate cells and its pharmacological modulation
Katrin Schölzel, Lisa Longato, Hazel Hummels, Tu Vinh Luong, Brian Davidson, Massimo Pinzani, Krista Rombouts
UCL Institute for Liver and Digestive Helath

1374 Novel treatment strategy for liver fibrosis by hybrid inhibitors targeting peripheral cannabinoid-1 receptors (CB1R) and inducible NO synthase (iNOS)
Resat Cinar, Malliga Iyer, Ziyi Liu, Tony Jourdan, Zongxian Cao, Katalin Erdelyi, Grzegorz Godlewski, Gergo Szanda, Jie Liu, Pal Pacher, Kenner Rice, George Kunos
National Institutes of Health

1375 Proof of liver regeneration after resolution of fibrosis by siRNA against HSP47 encapsulated in vitamin A-coupled liposome employing CCl4 mice engineered with Sox9-CreERT2/ROSA-YFP genes
Naoki Fujitani1, Akihiro Yoneda2, Yuya Murakami1, Miyuki Nishimura1, Miyono Miyazaki3, Keiko Kajiwara3, Kenjiro Minomi3, Yasuaki Tamura2, Yoshiro Niitsu1
1Sapporo Medical University, 2Institute for the Promotion of Business-Regional Collaboration, 3Hokkaido Laboratory, Nitto Denko Corporation

1376 Oral hepatotropic DPP4 inhibitors attenuate NASH and bilary fibrosis in part through macrophage modulation
Xiaoyu Wang1, Shih-Yen Weng1, Yong Ook Kim1, Thomas Klein3, Detlef Schuppan1, 2
1Institue of Translational Immunology, 2Division of Gastroenterology, 3Boehringer Ingelheim Pharma

1377 Branched-chain amino acids prevent hepatic fibrosis and the development of liver tumors by suppressing TGF-ß signaling
Kai Takegoshi1, Masao Honda1, Hikari Okada1, Riuta Takabatake1, Takayoshi Shirasaki1, Naoto Matsuzawa1, Toshinari Takamura1, Takuji Tanaka2, Shuichi Kaneko1
1Kanazawa University, 2Tohkai Cytopathology Institute

1378 Membrane type I-matrix metalloprotease-cleaved collagens derived from hepatic stellate cells play critical role in liver regeneration after partial hepatectomy in rats
Akihiro Yoneda1, 2, Miyuki Nishimura2, Naoko Urushihara2, 3, Tomoko M. Sudo2, 3, Kenjiro Minomi2, 3, Yasuaki Tamura1, Yoshiro Niitsu2
1Institute for the Promotion of Business-Regional Collaboration, Hokkaido University, 2Sapporo Medical University, 3Hokkaido Laboratory, Nitto Denko Corporation

1379 Selective antibody targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal via crosslinking-dependent and independent mechanisms
Naoki Ikenaga1, Susan B. Liu1, Zhen-Wei Peng1, Shuhei Yoshida1, Deanna Sverdlov1, Satyajit Karnik2, Amanda Mikels-Vigdal2, Victoria Smith2, Detlef Schuppan1, Yury Popov1
1Beth Israel Deaconess Medical Center , 2Gilead Sciences, Inc

1380 IL-22 enhances TGF-beta pro-fibrotic function in hepatic stellate cells in a p38/MAPK dependent manner.
Thomas Fabre1, 2, Manuel Flores Molina1, 2, Naglaa H. Shoukry1, 3
1Centre de recherche du CHUM, 2Université de Montréal, 3Université de Montréal

1381 MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis.
Eva Moran-Salvador, Pier P. Paoli, Graham R. Smith, Agata Page, Rachel M. Howarth, Fiona Oakley, Jelena Mann, Derek Mann
Newcastle University

1382 Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis
Fernando Magdaleno1, 2, Elena Arriazu2, Marina Ruiz de Galarreta2, Yu Chen1, Xiadong Ge1, 2, Laura Conde de la Rosa2, Natalia Nieto1, 2
1University of Illinois at Chicago, 2Icahn School of Medicine at Mount Sinai

1383 IL-10-producing regulatory B cells from chronic hepatitis B patients suppressed CD4+T cells proliferation and enhanced regulatory T cells function
Li-sha Cheng, Yun Liu, Wei Jiang
Zhongshan hospital

1384 SNAP-23 Heterozygous Mice Are Resistant To Experimental Fibrosis
Haleigh B. Eubanks, Jessica R. Goree, Michel Fausther, Jonathan A. Dranoff
University of Arkansas for Medical Sciences

1385 GP38/PODOPLANIN marks a novel subset of progenitor cells in chronic liver injury
Henrike Julich1, Christoph Eckert1, Yong Ook Kim2, Hannes Borchardt1, Niklas Klein1, Eva-Carina Heier1, Thomas Tschernig3, Detlef Schuppan2, Veronika Lukacs-Kornek1
1Saarland University, 2Johannes Gutenberg University, 3Saarland University

1386 Characterization of obesity-related modifications in hepatic stellate cells
Guanhua Xie1, Marzena Swiderska-Syn1, Mariana V. Machado1, Mark Jewell1, Richard T. Premont1, Gregory A. Michelotti1, Raffaele Teperino2, Anna Mae Diehl1
1Duke University Medical Center, 2Institute of Experimental Genetics (IEG) - HDC

1387 Mice lacking calmodulin kinase II gamma (CaMKII gamma) are resistant to experimental fibrosis/cirrhosis
Elise G. Lavoie, Jessica R. Goree, Jonathan A. Dranoff
University of Arkansas for the Medical Sciences

1388 Engineering Healthy And Cirrhotic Human Liver Matrix: A New 3D Platform For Investigating Liver Cirrhosis And HCC
Giuseppe Mazza2, Lisa Longato2, Walid Al-Akkad1, Andrea Telese2, Luca Urbani3, Andrew R. Hall2, Benjamin Robinson4, Luca Frenguelli2, Oliver Willacy2, Marco Curti2, Kevin Moore2, Domenico Tamburrino5, Gabriele Spoletini5, Massimo Malago2, Tu Vinh Luong2, Armando E. Del Rio Hernandez4, Paolo De Coppi3, Krista Rombouts2, Massimo Pinzani2
1UCL, 2UCL, Institute for Liver and Digestive Health, 3UCL, Institute for Child Health, 4Imperial College, 5Royal Free, Division of Surgery

1389 Rev-erb and TGF-ß Differentially Regulate Autophagy in Hepatic Stellate Cells
Paul G. Thomes1, Nicole A. Feilen1, Jennifer H. Benbow1, Elizabeth Brandon-Warner1, Cathy Culberson1, Terrence M. Donohue2, Laura W. Schrum1
1Carolinas Medical Center, 2Omaha VA Medical Center & Univ. of Nebraska Medical Center

1390 Molecular mechanism responsible for tissue stiffness in advanced chronic liver fibrogenesis
Takao Sakai
Institute of Translational Medicine, University of Liverpool

1391 Antifibrogenic properties of monoacylglycerol lipase inhibitors
Aida Habib1, Jinghong Wan1, Pushpa Hegde1, Emmanuel Weiss1, Arthur Brouillet2, Richard Moreau1, Sophie Lotersztajn1
1Inserm U1149, Center for Research on inflammation, 2Inserm U955

1392 Induction of XBP1 Leads to Hepatic Stellate Cell Activation
Rosa S. Kim, Daisuke Hasegawa, Xiaochen Sun, Takuma Tsuchida, Dipankar Bhattacharya, Hsin I Chou, David Y. Zhang, Yujin Hoshida, Scott L. Friedman
Icahn School of Medicine at Mount Sinai

1393 Role of CREBH activation induced by HCV infection in up-regulation of TGF-ß2 expression and fibrogenesis
Takeshi Chida1, 2, Masahiko Ito1, Kazuhito Kawata2, Yoshimasa Kobayashi2, Tetsuro Suzuki1
1Hamamatsu university school of medicine, 2Hamamatsu university school of medicine

1394 Expression of ENTPD1/CD39 is protective in a mouse model of biliary fibrosis
Linda Feldbrügge1, 3, Shuji Mitsuhashi1, Eva Csizmadia1, Xiaofeng Sun1, Moritz Schmelzle2, Simon C. Robson1
1BIDMC, 2Charité, 3University Hospital Leipzig

1395 Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice by rescuing Mig-6, EGFR/MET signal inhibitor.
Hikari Okada1, Masao Honda1, Jean S. Campbell2, Kai Takegoshi1, Yoshio Sakai1, Taro Yamashita1, Takayoshi Shirasaki1, Riuta Takabatake1, Mikiko Nakamura1, Takuji Tanaka3, Shuichi Kaneko1
1Kanazawa University Graduate School of Medical Science, 2University of Washington School of Medicine, 3The Tohkai Cytopathology Institute

1396 Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-ß1
Jingjing Ge, Na Chang, Zhongxin Zhao, Lei Tian, Lin Yang, Liying Li
Capital Medical University

1397 HIV infected Kupffer cells mediate pro-fibrogenic effects on stellate cells through secretion of TGFß1
Ankur Panchal, Arevik Mosoian, Lumin Zhang, M. Isabel Fiel, Sander S. Florman, Myron E. Schwartz, Andrea D. Branch, Meena B. Bansal
Icahn School of Medicine at Mount Sinai

1398 Melatonin Suppresses Activation of Hepatic Stellate Cells through RORa-mediated inhibition of 5-lipoxygenase.
Shiva Shajari1, Almudena Laliena1, 2, Janette Heegsma1, María Jesús Tunõn2, 3, Han Moshage1, Klaas Nico Faber1
1University Medical Center Groningen, 2Institute of Biomedicine (IBIOMED) , 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)

1399 Single adenoviral delivery of relaxin attenuates established liver fibrosis by suppressing collagen cross-link and enhancing collagen degradation
Jung Il Lee1, Ja Kyung Kim1, Hye Young Chang2, Kwan Sik Lee1
1Yonsei University, 2Yonsei University College of Medicine

1400 Galectin-1 promotes the activation of hepatic stellate cell and liver fibrosis through glycosylation-dependent interactions
Ming-Heng Wu
Taipei Medical University

1401 TRPC6 Channels Contribute to Hepatic Stellate Cell Activation Leading to Liver Fibrosis
Kyu-Hee Hwang, Ji-Hee Kim, Soo-Jin Kim, Kyu-Sang Park, Seung-Kuy Cha
Yonsei University Wonju College of Medicine

1402 Targeting Activated Stromal Fibroblasts in Primary Sclerosing Cholangitis
Anja Moncsek1, Achim Weber2, Beat Mullhaupt1, Joachim C. Mertens1
1University Hospital Zürich, 2University Hospital Zürich

1403 Modulation of Extracellular Matrix Remodeling by Activation of the Aryl Hydrocarbon Receptor
Cheri L. Lamb1, 2, Kristen A. Mitchell1, 2
1Boise State University, 2Boise State University

1404 MicroRNA profiling of circulating exosomes in HBV cirrhosis patients following anti-HBV therapy
Min Cong1, Li Chen2, Tianhui Liu1, Ping Wang1, Jidong Jia1, David Brigstock2, Hong You1
1Beijing Friendship Hospital, 2The research Institute at Nationwide Children's Hospital

1405 Identification of Axon guidance signaling pathway mediators in hepatic stellate cells and liver fibrogenesis
Jinsheng Guo1, David Zhang2, Yujing Wu1, Daisuke Hasegawa2, Scott L. Friedman1, 2
1Zhong Shan Hospital, Fu Dan University, 2 Icahn School of Medicine at Mount Sinai

1406 PDGFRa ubiquitination leads to its p62 mediated autophagic degradation in a synectin dependent manner in HSC
Haibin Yu, Mary Drinane, Usman Yaqoob, Vikas K. Verma, Thiago de Assuncao, Sheng Cao, Vijay Shah
Mayo Clinic

1407 Reactive gamma-ketoaldehydes induce a proinflammatory phenotype, oxidative stress, and activation of autophagy in primary human hepatic stellate cells
Lisa Longato1, Fausto Andreola1, Sean S. Davies2, Jackson L. Roberts2, Giuseppe Fusai1, Massimo Pinzani1, Kevin Moore1, Krista Rombouts1
1University College London, 2Vanderbilt University

1408 Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation.
Luigi Locatelli, Pier P. Paoli, Timothy Hardy, Rachel M. Howarth, Fiona Oakley, Derek Mann
Newcastle University

1409 Human precision Cut Liver Slices model for testing anti-fibrotic drugs
Lynda Aoudjehane1, 2, Margaux Legrand1, Grégoire Bisch1, Rolland Delelo2, Chantal Housset2, Pierre Balladur3, Claire Goumard4, Jérôme Becquart1, Yvon Calmus2, 5, Filomena Conti2, 5
1Faculté de Médecine Pierre et Marie Curie, 2CDR Saint-Antoine, 3Service de Chirurgie Digestive, 4Service de Chirurgie Digestive, 5Unité de Transplantation Hépatique

1410 The AMPK-related kinase NUAK2 interacts with TGF-ß and regulates the activation of hepatic stellate cells
Cristina Tosti Guerra1, Alessandra Caligiuri1, Angela Provenzano1, Krista Rombouts2, Massimo Pinzani2, Fabio Marra1
1University of Florence, 2University College London

1411 The bile acid-phospholipid conjugate Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) disturbs pro-fibrogenic Integrin and TGFß signaling
Jie Su, Hongying Gan-Schreier, Walee Chamulitrat, Wolfgang Stremmel, Anita Pathil
University of Heidelberg

1412 Curcumin blocks the loss of lipid droplets in activated hepatic stellate cells by increasing perilipin 5 gene expression in vitro
DingYu Zhang
Wuhan Medical Treatment Center

1413 Versican: A Novel Modulator of Hepatic Fibrosis
Terence N. Bukong1, Sean B. Maurice1, 2, Barinder Chahal2, 1, David Schaeffer2, Paul J. Winwood2, 1
1University of Northern BC, 2University of British Columbia

1414 Hepatic stellate cell-derived retinoid enhances functional maturity of human embryonic stem cell-derived hepatocytes on drug metabolism
Hyuk-Soo Eun, Wonhyo Seo, Won-IL Jeong
KAIST

1415 Calcium Mobilization through L-type Channels in Hepatic Stellate Cell is Essential for TGF-b-mediated CTGF Induction in Pyk2-dependent Manner.
Jonghwa Kim1, SoHee Kang1, Soohyun Park1, Ju-Yeon Cho1, Won Sohn1, David A. Brenner 2, Yong-Han Paik1
1Samsung medical center, 2UC San Diego

1416 Paracrine suppression of proliferation and activation of hepatic myofibroblasts by adipose-derived stem cells
Danial Afsharzadeh2, Shiva Shajari1, Linda Brouwer2, Han Moshage1, Martin C. Harmsen2, Klaas Nico Faber1
1University medical center Groningen, 2University Medical Center Groningen

1418 Deactivation of human and rat cirrhotic hepatic stellate cells: a novel alternative use for the glucagon-like 1 receptor agonist Liraglutide.
Fernanda C. de Mesquita1, 2, Sergi Guixé-Muntet1, Jose Luis Rosa3, Jaime Bosch1, Jarbas R. de Oliveira2, Jordi Gracia-Sancho1
1IDIBAPS - Hospital Clinic de Barcelona - CIBEREHD, 2PUCRS, 3Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), University of Barcelona

1419 Serine Protease Omi/HtrA2 Reduces Oxidative Stress and Preserves Mitochondrial Function in Liver Fibrosis
Seung Kew Yoon1, 2, Wonhee Hur1, Joon Ho Lee1, Sung Woo Hong1, Jung-Hee Kim1, Jung Eun Choi1, Sung Min Kim1, Eun Byul Lee1
1The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, 2St. Mary's Hospital, The Catholic University of Korea

1420 Cancer associated fibroblasts in intrahepatic cholangiocarcinoma is derived from portal fibroblasts, but not hepatic stellate cells; immunohistochemical study in human tissues.
Naoki Uyama1, Rei A. Ito1, Ami Kurimoto1, Tomohiro Okamoto1, Akito Yada1, Hideaki Sueoka1, Seikan Hai1, Hisashi Kosaka1, Yuichi Kondo1, Ikuo Nakamura1, Kazuhiro Suzumura1, Yasukane Asano1, Toshihiro Okada1, Tadamichi Hirano1, Junichi Yamanaka1, Norifumi Kawada2, Jiro Fujimoto1
1Hyogo College of Medicine, 2Osaka City University Graduate School of Medicine,

1421 Human neutrophil peptide-1 enhances alcohol-induced hepatocyte apoptosis in vivo and in vitro.
Rie Ibusuki2, 1, Hirofumi Uto2, 3, Masaya Kozono2, Kohei Oda2, Akihiko Oshige2, Kotaro Kumagai2, Seiichi Mawatari2, Tsutomu Tamai2, Akihiro Moriuchi2, Hirohito Tsubouchi4, 5, Takezaki Toshiro1, Akio Ido2, 4
1Kagoshima University Graduate School of Medical and Dental Sciences, 2Kagoshima University Graduate School of Medical and Dental Sciences, 3Miyazaki Medical Center Hospital,, 4Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 5 Kagoshima City Hospital,

1422 Liver Fibrosis in a Mouse Model of Non-alcoholic Fatty Liver Disease is Mediated by Hepatocyte Hypoxia Inducible Factor-1
Omar Mesarwi, Mi-Kyung Shin, Shannon Bevans-Fonti, Vsevolod Polotsky
Johns Hopkins University

Clinical and Translational Fibrosis Research

1423 Treatment of Hepatic Fibrosis using amniotic fluid derived mesenchymal stem cells overexpressing interleukin-17 receptor like molecule
Peipei Wang1, 2, Qiyi Zhao1, 2, Liang Peng1, 2, Zhanlian Huang1, 2, Shicheng Su3, Zhiliang Gao1, 2
1Third Affiliated Hospital of Sun Yat-sen University, 2Third Affiliated Hospital of Sun Yat-sen University, 3Sun Yat-sen University

1424 The epidemiology of cirrhosis in Hispanics in South Texas
Jingjing Jiao1, Gordon P. Watt2, Kristina Vatcheva2, Jen-Jung Pan3, Joseph B. McCormick2, Susan Fisher-Hoch2, Michael B. Fallon3, Laura Beretta1
1MD Anderson Cancer Center, 2School of Public Health, University of Texas Health Science Center at Houston, Brownsville Regional Campus, 3University of Texas Health Science Center at Houston Medical School

1425 Novel assessment of hepatic collagen turnover rate and its quantitative association with NASH and stage of fibrosis: prospective validation of a non-invasive marker against liver biopsy.
Claire Emson1, Martin Decaris1, Scott M. Turner1, Carine Beysen1, Kelvin Li1, Carolyn Hernandez3, Jeffrey Y. Cui3, Leander Lazaro3, David A. Brenner 2, Marc Hellerstein1, 4, Rohit Loomba3, 2
1KineMed, 2University of California San Diego, 3University of California San Diego, 4University of California Berkeley

1426 In vivo cell specific gene silencing in the liver using novel siRNA-loaded nanohydrogel particles
Leonard Kaps
Institute of Translational Immunology and Research Center for Immunotherapy (FZI)

1427 Host microbiota dictates the profibrotic impact of PAMPs in the liver
Suriguga Suriguga1, Floris Fransen2, Dorenda Oosterhuis1, Geny M. Groothuis3, Paul d. Vos2, Henricus A. Mutsaers1, Peter Olinga1
1University of Groningen, 2University of Groningen, 3University of Groningen

1428 Correlations between hepatic morphometric collagen content, histologic fibrosis staging, and serum markers in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)
Zachary D. Goodman1, Lakshmi Alaparthi1, Fanny Monge1, Keyur Patel 2, Rohit Loomba3, Stephen H. Caldwell4, Eric Lawitz5, Stephen A. Harrison6, Mitchell L. Shiffman7, Manal F. Abdelmalek2, Robert P. Myers8, Raul E. Aguilar Schall8, Mani Subramanian8, John G. McHutchison8, Vlad Ratziu9, Arun J. Sanyal10, Nezam H. Afdhal11
1Inova Fairfax Hospital, 2Duke Clinical Research Institute, 3University of California at San Diego, 4University of Virginia, 5Texas Liver Institute, University of Texas Health Science Center, 6San Antonio Military Medical Center, 7Liver Institute of Virginia, 8Gilead Sciences, Inc., 9Hopital Pitie-Salpretriere, 10Virginia Commonwealth University, 11Beth Israel Deaconess Medical Center and Harvard Medical School

1429 Concerted effects of the two major genetic risk factors for cholestatic (ABCB4) and fatty liver disease (PNPLA3) on liver fibrosis: elastography-based study in chronic liver disease
Marcin Krawczyk2, 1, Frank Grünhage2, Frank Lammert2
1Medical University of Warsaw, 2Saarland University Medical Center

1430 Innate Lymphoid Cell (ILC) Subset Composition of Human Liver: Enrichment for ILC1s in Hepatic Cirrhosis
Lucy Golden-Mason1, Silvia Giugliano1, Linling Cheng1, Hugo R. Rosen1, 2
1Univ Colorado Denver, 2Veteran’s Affairs Medical Center

1431 Risk of cirrhosis in first degree relatives of patients with NAFLD cirrhosis: A prospective study
Rohit Loomba1, Jeffrey Y. Cui2, Ricki Bettencourt3, Nicholas Schork4, Chi-Hua Chen5, Mahdi Al Ikhwan2, Archana Bhatt2, Lisa M. Richards2, Claude B. Sirlin5, David A. Brenner 2
1University of California at San Diego, 2UCSD School of Medicine, 3UCSD School of Medicine, 4J Craig Venter Institute, 5UCSD School of Medicine

1432 A marker of true type III collagen formation (Pro-C3) predicts rapid fibrosis progression in post-liver transplant patients
Mette J. Nielsen1, 2, Tim Zimmermann3, Morten A. Karsdal1, Diana J. Leeming1, Detlef Schuppan4, 5
1Nordic Bioscience A/S, 2University of Southern Denmark, 3Mainz University Medical Center, 4Mainz University Medical Center, 5Beth Israel Deaconess Medical Center, Harvard Medical School

1433 Safety, Pharmacokinetics, and Biologic Activity of ND-L02-s0201, a Novel Targeted Lipid-Nanoparticle to Deliver HSP47 siRNA for the Treatment of Patients with Advanced Liver Fibrosis: Interim Results from Clinical Phase 1b/2 Studies
Eric Lawitz2, Yasunobu Tanaka3, Fred Poordad2, Julio A. Gutierrez2, Kathy Carr4, Wenbin Ying1, Yoshiro Niitsu5, Kageshi Maruyama3
1NDT, 2Texas Liver Institute, University of Texas Health Science Center, 3Nitto Denko Corporation, 4RRD International, RRD International, LLC, 5Sapporo Medical University

1434 Antifibrotic efficacy of a TGF-ß kinase inhibitor on early-onset and end-stage of fibrosis in precision-cut human liver slices
Theerut Luangmonkong1, 2, Suriguga Suriguga1, Emilia Bigaeva1, Dorenda Oosterhuis1, Koert P. de Jong3, Detlef Schuppan4, 5, Henricus A. Mutsaers1, Peter Olinga1
1University of Groningen, 2Mahidol University, 3University Medical Center Groningen, 4Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, 5Beth Israel Deaconess Medical Center, Harvard Medical School

1435 Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH)
Stephen A. Harrison1, Zachary D. Goodman2, Vlad Ratziu3, Rohit Loomba4, Anna Mae Diehl5, Eric Lawitz6, Holger Hinrichsen7, Kiran Bambha8, Manal F. Abdelmalek5, Robert P. Myers9, Raul E. Aguilar Schall9, Mani Subramanian9, John G. McHutchison9, Nezam H. Afdhal10, Andrew J. Muir5
1San Antonio Military Medical Center, 2Inova Fairfax Hospital, 3Hôpital Pitié-Salpêtrière, 4University of California at San Diego, 5Duke Clinical Research Institute, 6Texas Liver Institute, University of Texas Health Science Center, 7Gastroenterologisch-Hepatologisches Zentrum, 8University of Colorado Denver, 9Gilead Sciences, Inc., 10Beth Israel Deaconess Medical Center and Harvard Medical School

1436 Collagen scoring by qFibrosis in paired liver biopsies from chronic hepatitis C patients before and after treatment
Huiying Rao1, Feng Liu1, Aileen -. Wee2, Bo Feng1, Ming Yang1, Lai Wei1
1Peking University People’s Hospital, Peking University Hepatology Institute, 2Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore

1437 Collagen and tissue turnover as function of age – implications for fibrosis
Morten A. Karsdal1, Federica Genovese1, Emilie A. Madsen1, Tina Manon-Jensen1, Detlef Schuppan2, 3
1Nordic Bioscience, 2Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, 3Beth Israel Deaconess Medical Center, Harvard Medical School

1438 New Prognostic Model for 1-year Mortality in patients with Decompensated Hepatitis B virus-related Liver Cirrhosis receiving antiviral treatment
Tae Hyung Kim1, Daehoe Gu1, Soon Ho Um1, Tae Jung Yun1, Sun Young Yim1, Yeon Seok Seo1, Hyung Joon . Yim1, Bora Keum1, Beom Jin Park2
1Korea University college of Medicine, 2Korea University Anam hospital

1439 Comparison of 16 blood and/or elastometric fibrosis tests in 5 causes of chronic liver diseases: too much? Towards a simplification
Jerome Boursier1, 2, Alexandra Ducancelle3, 2, Vincent Leroy4, Julien Vergniol5, Nathalie Sturm6, Brigitte Le Bail7, Jean-Pierre H. Zarski4, Victor de Ledinghen5
1University Hospital, 2University, 3University Hospital, 4University Hospital, 5University Hospital, 6University Hospital, 7University Hospital

1440 Collagen proportionate area correlates accurately to Ishak score, transient and 2D shear wave elastography in assessment of fibrosis in alcoholic liver disease
Linda S. Møller2, 1, Maja Thiele2, 3, Sönke Detlefsen4, Bjørn S. Madsen2, 3, Janne F. Hansen5, 2, Annette D. Fialla2, 6, Aleksander Krag2
1Odense University Hospital Svendborg, 2Odense University Hospital, 3Odense University Hospital, 4Odense University Hospital, 5Odense Univerity Hospital, 6Hospital of Southwest Jutland

1441 Comparing the liver stiffness by transient elastography in cirrhosis patients with PBC and HBV to predict the risk of esophageal variceal bleeding
Ying Huang1, Haiyun Zhang1, Li Xiao1, Liqing Zhu1, Qingjing Zhu2, Xiaohua Hou1, Ling Yang1
1Huazhong University of Science&Technology, 2Wuhan Medical Treatment Center

1442 Lysyl oxidase-like-2 (LOXL2) levels decline with sofosbuvir (SOF)-based therapy in patients with hepatitis C virus (HCV)-related cirrhosis
Nezam H. Afdhal1, Christophe Hézode2, K. Rajender Reddy3, Steven L. Flamm4, Robert P. Myers5, Raul E. Aguilar Schall5, Robert H. Hyland5, Phillip S. Pang5, Diana M. Brainard5, Mani Subramanian5, John G. McHutchison5, Michael R. Charlton6, Marc Bourlière7
1Beth Israel Deaconess Medical Center and Harvard Medical School, 2Gastro-Entérologie, Hôpital Henri Mondor, Université Paris-Est, INSERM U 955, 3University of Pennsylvania, 4Northwestern University, 5Gilead Sciences, Inc., 6Intermountain Medical Center, 7Hépato-Gastro-Entérologie, Hôpital Saint Joseph

1443 How gold is the “gold standard” method for staging liver fibrosis?
Ioan Sporea
University of Medicine and Pharmacy Timisoara

1444 Reproductive Aging, Independent of Chronologic Age, Is Associated with Accelerated Fibrosis Progression in HIV/HCV Co-Infected Women
Monika Sarkar1, Jennifer L. Dodge1, Ruth Greenblatt1, Mark H. Kuniholm2, Jack Dehovitz3, Michael Plankey9, Andrea Kovacs4, Audrey French7, Eric C. Seaberg8, Igho Ofotokun5, Margaret Fischl6, Edgar T. Overton10, Erin Kelly1, Peter Bacchetti1, Marion G. Peters1
1University of California, San Francisco, 2Albert Einstein College of Medicine, 3SUNY Downstate Medical Center, 4University of Southern California, 5Emory University, 6University of Miami , 7Cook County Health and Hospitals System, 8Johns Hopkins University, 9Georgetown University Medical Center, 10University of Alabama

1445 Azathioprine exerts an antifibrotic effect on primary human hepatic stellate cells
Pinelopi Manousou, Thomas C. Shepherd, Lisa Longato, Michela Borghesan, Krista Rombouts, Massimo Pinzani
Royal Free Hospital and UCL

1446 Serum wisteria floribunda agglutinin-positive human mac-2 binding protein (WFA+-M2BP) levels of severe fibrosis varies according to the etiology of liver disease
Hiroki Ikeda, Ryuta Shigefuku, Noburiro Hattori, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro Suzuki, Fumio Itoh
St. Marianna University, School of medicine

1447 A novel canine liver cirrhosis model to develop less invasive liver regeneration therapy using cultured bone marrow-derived cells
Takashi Matsuda1, 2, Taro Takami1, Yuki Aibe1, Toshihiko Matsumoto1, 4, Tsuyoshi Ishikawa1, Naoki Yamamoto1, 5, Shuji Terai3, Isao Sakaida1, 6
1Yamaguchi University Graduate School of Medicine, 2Sanyo-Onoda General Hospital, 3Niigata University, 4Yamaguchi University Graduate School of Medicine, 5Yamaguchi University, 6Yamaguchi University Graduate School of Medicine

1448 A novel glycobiomarker, Wisteria floribunda agglutinin Macrophage Colony-Stimulating Factor Receptor can predict carcinogenesis and survival of liver cirrhosis with hepatitis C virus
Etsuko Iio1, 3, Makoto Ocho2, Akira Togayachi2, Masanori Nojima4, Atsushi Kuno2, Masashi Mizokami5, Hiroshi Yatsuhashi6, Tatsuya Ide7, Shunsuke Nojiri3, Hisashi Narimatsu2, Yasuhito Tanaka1
1Nagoya City University Graduate School of Medical Sciences, 2National Institute of Advanced Industrial Science and Technology, 3Nagoya City University Graduate School of Medical Sciences, 4University of Tokyo, 5Kohnodai Hospital, International MedicalCenter, 6National Nagasaki Medical Center, 7Kurume University

1449 Second harmonic generation microscopy based quantitative assessment for HBV-associated liver fibrosis.
Kai-Wen Huang
National Taiwan University Hospital

1450 Hepatitis C treatment and Progression of Liver Stiffness in Australia, subsequent to the introduction of protease inhibitors
Yang Wu1, Hank H. Chen1, Martin Weltman1, Guy D. Eslick2, Bilel Jideh1, Izabella Pokorski1
1Nepean Hospital, 2Nepean Hospital

Cost-Effectiveness and Economics of Care

1451 The Attention-to-Burden Index (ABI): a New Tool that Reveals Profound Disparities between Research Attention and Disease Burden among Liver Diseases.
Nambi J. Ndugga1, Teisha G. Lightbourne2, Kavon Javaherian2, Neha Verma2, Eric S. Orman3, David Pesci2, Ramon Bataller4, 2
1University of North Carolina at Chapel Hill School of Medicine, 2University of North Carolina at Chapel Hill , 3University of North Carolina at Chapel Hill, 4University of North Carolina at Chapel Hill School of Medicine

1452 Hospital Based Initiative to Decrease Readmission Rates in End-Stage Liver Disease
Sheela S. Reddy1, Chad Gorn2, Stephania Dottin2, Ann E. Burke1, Karen Newell2, Karen Pine2, Ursula Hobbs2, Maria Neff2, Jonathan M. Fenkel1, David A. Sass1, Steven K. Herrine1, Jesse M. Civan1, She-Yan Wong1, Dina Halegoua-De Marzio1
1Thomas Jefferson University, 2Thomas Jefferson University Hospital

1453 Cost-effectiveness of Sofosbuvir plus Ledipasvir Antiviral Treatment for Elderly Patients with Chronic Hepatitis C Genotype 1
Antonio Ciaccio2, Paolo Cortesi3, Giuseppe Bellelli4, Matteo Rota5, Monica Rota2, Lorenzo G. Mantovani3, Giorgio Annoni4, Mario Strazzabosco 1, 2
1Yale University, Section of Digestive Diseases, 2University of Milano-Bicocca, 3University of Milan-Bicocca, 4University of Milan-Bicocca, 5IRCCS-Istituto di Ricerche Farmacologiche Mario Negri

1454 Living Donor Liver Transplants (LDLT), compared to Deceased Donor Liver Transplants (DDLT), and MELD Score Increase Liver Transplant Resource Utilization at an Experienced Transplant Center from June 2008 to July 2013
Grace Kim1, Yael J. Coppleson2, Robert S. Brown3, 2, Thresiamma Lukose1, Jean C. Emond1, 2, Benjamin Samstein2
1Columbia University, 2NewYork Presbyterian, 3Columbia University

1455 A probabilistic decision model using non-invasive fibrosis markers in Primary Care NAFLD pathways predicts increased cirrhosis detection rates and reduced overall healthcare expenditure
Ankur Srivastava1, 2, Simcha Jong3, Anna Gola4, Laura Fenlon5, Petra Scantlebury5, Sudeep Tanwar1, 2, Hannah Liu7, Ruth E. Gailer6, 7, Sarah Morgan6, Alex Warner6, Karen Sennett7, Julie Parkes1, James O'Beirne1, 2, Emmanuel Tsochatzis1, 2, William M. Rosenberg1, 2
1University College London (UCL), 2Royal Free London NHS Foundation Trust, 3University College London, 4University College London, 5Royal Free London NHS Foundation Trust, 6Camden Clinical Commissioning Group, 7Islington Clinical Commissioning Group

1456 Impact of Daclatasvir-Sofosbuvir Combination Treatment on Medical Events and Costs in Patients Infected with Genotype 3 Hepatitis C Virus
Boris Gorsh1, Bruce E. Sill1, Shalini Hede1, Catherine St-Laurent Thibault2, Divya Moorjaney3, Michael Ganz3, Anupama Kalsekar1, Yong Yuan1
1Bristol-Myers Squibb, 2Evidera , 3Evidera

1457 Hospitalisation for primary biliary cirrhosis: a UK-PBC analysis of hospital episodes
Gideon Hirschfield2, Luke Vale3, Tracy J. Mayne1, George F. Mells4, David Shapiro1, David Jones5
1Intercept Pharmaceuticals, 2University of Birmingham, 3Newcastle University, 4University of Cambridge, 5Newcastle University Medical School

1458 Obeticholic Acid (OCA) has Incremental Efficacy in Patients with Higher Baseline Alkaline Phosphatase (ALP) Levels
Tracy J. Mayne, Richard Pencek, Tonya Marmon, David Shapiro
Intercept Pharmaceuticals, Inc.

1459 Impact of Comorbidity on Inpatient Outcomes for Decompensated Cirrhosis
Brandon Nokes2, 1, Amit Kashyap3, Thomas D. Boyer4, 3, Archita P. Desai4, 3
1Mayo Clinic Arizona, 2University of Arizona, 3University of Arizona, 4University of Arizona

1460 Superiority and Durability of Improvements in Work Productivity (WP) and Patient Reported Outcomes (PROs) with Interferon (IFN)-Free and Ribavirin (RBV)-Free Regimens for Chronic Hepatitis C (CH-C)
Zobair M. Younossi1, 2, Maria Stepanova3, Linda Henry3, Fatema Nader1, Sharon L. Hunt3
1Inova Fairfax Hospital, 2Inova Health System, 3Center for Outcomes Research in Liver Disease

1461 Cost-effectiveness of Daclatasvir in Combination with Sofosbuvir for the Treatment of Subjects with Genotype 3 Chronic Hepatitis C Infection in the United States
Catherine St-Laurent Thibault1, Divya Moorjaney1, Michael Ganz1, Bruce E. Sill2, Shalini Hede2, Yong Yuan2, Anupama Kalsekar2, Boris Gorsh2
1Evidera, 2Bristol-Myers Squibb Company

Encephalopathy and Other Complications of Cirrhosis

1462 The cost-effectiveness of ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin (3D+R) in patients with liver transplantation after genotype 1 hepatitis C virus infection
Sammy Saab2, Yuri Sanchez3, Caroline Huber1, Alice Wang3, Timothy R. Juday3
1Precision Health Economics, 2University of California, Los Angeles, 3AbbVie, Inc.

1463 Gut Microbiota Alterations are an Independent Prognostic Factor for 90-day hospitalization in Cirrhosis
Jasmohan S. Bajaj1, Naga Betrapally2, Douglas M. Heuman1, Melanie White1, Ariel Unser1, Edith A. Gavis1, Phillip B. Hylemon1, Leroy Thacker1, Masoumeh Sikaroodi2, Patrick M. Gillevet2
1VCU and McGuire VAMC, 2Geoge Mason University

1464 Clinical Characteristics of Portosystemic Shunt Occlusion for Refractory Hepatic Encephalopathy: A Comparison with Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Varices
Tatsuro Nishimura, Tsuyoshi Ishikawa, Ryo Sasaki, Yuki Aibe, Shogo Shiratsuki, Kazuhito Matsunaga, Takuya Iwamoto, Taro Takami, Isao Sakaida
Yamaguchi University Graduate School of Medicine

1465 Lactulose treatment improves cognition, quality of life and intestinal microbiota in minimal hepatic encephalopathy patients: results from a multi-center, randomized, controlled trial
Jiyao Wang1, Jiang-bin Wang2, Jia Shang3, Xin-Min Zhou4, Xiao-Lin Guo5, Xuan Zhu6, Li-Na Meng7, Hai-Xing Jiang8, Yu-Qiang Mi9, Jian-Ming Xu10, Jin-Hui Yang11
1Zhong Shan Hospital,Fudan University, 2China-Japan Union Hospital, Jilin University, 3Departmentof Infectious Diseases, Henan Provincial People’s Hospital, 4Xijing Hospital, the Fourth Military Medical University, 5The First Hospital of Jilin University, 6The first Affiliated Hospital of Nanchang University, 7Zhejiang Provincial Hospital of Tranditional Chinese Medicine, 8The First AffiliatedHospital of Guangxi Medical University,, 9Tianjin Second People’s Hospital, 10The First Affiliated Hospital of Anhui Medical University, 11The second Affiliated Hospital of Kunming Medical University

1466 Transient elastography related cut off parameters in patients with advanced chronic liver disease independently predict decompensation and mortality but lack prediction of varices.
Rafael Paternostro, Monika Ferlitsch, Alexandra Etschmaier, Remy Schwarzer, Thomas Reiberger, Mattias Mandorfer, Michael Trauner , Markus Peck-Radosavljevic, Arnulf Ferlitsch
Medical University of Vienna

1467 Development of an Electronic Diary (E-Diary) for Caregivers (CG) of Patients with Overt Hepatic Encephalopathy (OHE)
R Todd Frederick1, Marwan Ghabril2, Karin Coyne3, Mary Kay Margolis3, 4, Michael Santoro5, Dion F. Coakley5, Masoud Mokhtarani5, Bruce F. Scharschmidt5, Marzena Jurek 5
1California Pacific Medical Center , 2Indiana University , 3Evidera, 4Patient-Centered Outcomes Research Institute (PCORI), 5Horizon Therapeutics (formerly Hyperion Therapeutics, Inc.)

1468 Muscle mass in liver transplant candidates: From the Fitness, Life Enhancement, and Exercise in Transplantation (FLEXIT) Consortium
Jennifer C. Lai1, Elizabeth J. Carey2, Connie W. Wang1, Srinivasan Dasarathy3, Michael A. Dunn4
1UCSF, 2Mayo Clinic Arizona, 3Cleveland Clinic, 4University of Pittsburgh

1469 Obesity Paradox: Obesity is associated with lower risk of inpatient mortality in patients with cirrhosis, Nationwide Inpatient Sample
Benjamin Shao1, Dorothy Wakefield2, Gyorgy Baffy3, Raffi Karagozian1
1University of Connecticut, School of Medicine, 2UConn Health, 3VA Boston Healthcare System

1470 Plasma Metabolomic Profiling in Hepatopulmonary Syndrome
Michael B. Fallon1, Michael J. Krowka3, Kimberly A. Forde2, Karen Krok2, MAMTA PATEL2, Grace Lin3, Jae K. Oh3, Carl Mottram3, Paul D. Scanlon3, Sachin Batra1, David S. Goldberg2, Steven M. Kawut2
1University of Texas Health Science at Houston, 2Perelman School of Medicine , 3Mayo Clinic

1471 Bioelectrical impedance vector analysis (BIVA) is an objective method for nutritional assessment in patients with cirrhosis.
Astrid Ruiz-Margáin1, Ricardo Macías-Rodríguez1, Angeles Espinosa-Cuevas2, Andres Duarte-Rojo3, Luis A. Chi-Cervera1, Silvia L. Ríos-Torres1, Paola A. Rodríguez-Córdova1, Geraldine Osalde-Solís1, Aldo Torre1
1Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubiran", 2Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", 3University of Arkansas for Medical Sciences

1472 Is it safe for patients with minimal hepatic encephalopathy to drive? A prospective study of 163 patients linking simulation with real-life crashes
Mette M. Lauridsen1, 2, Vishwadeep Ahluwalia1, Ariel Unser1, Melanie White1, Richard K. Sterling1, R. Todd Stravitz 1, Scott C. Matherly1, Puneet Puri1, Arun J. Sanyal1, Velimir A. Luketic1, Mohammad S. Siddiqui1, Douglas M. Heuman1, Michael Fuchs1, Jasmohan S. Bajaj1
1Virginia Commonwealth University Medical Centre, 2Hospital of Southwest Jutland

1473 Randomized Controlled Trial on Efficacy of Nutritional Therapy on Cognitive Functions and Health Related Quality of Life in Patients of Liver Cirrhosis with Minimal Hepatic Encephalopathy
Sudhir Maharshi, Barjesh C. Sharma, Sanjeev Sachdeva, Siddharth Srivastava
G B Pant Institute of Post graduate Medical Education and Research

1474 Usefulness of Balloon-Occluded Retrograde Obliteration (B-RTO) as a Therapeutic Procedure to Improve Liver Function in Cirrhotic Patients with Porto-Systemic Shunts
Manabu Nakazawa, Yukinori Imai, Satsuki Ando, Kayoko Sugawara, Mie Inao, Nobuaki Nakayama, Satoshi Mochida
Saitama medical university hospital

1475 Six-week administration of lactulose in patients with cirrhosis does not alter the gut bacterial flora
Amit Goel1, Aditya N. Sarangi2, Ankur Singh1, S. Avani1, Rakesh Aggarwal1, 2
1Sanjay Gandhi Postgraduate Institute of Medical Sciences, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences

1476 Erectile Dysfunction in patients with cirrhosis
Sergio Maimone1, Giovanni Oliva1, 2, Antonino Di Benedetto2, Roberto Filomia1, 2, Gaia Caccamo1, Carlo Saitta1, Irene Cacciola1, 2, Giovanni Squadrito1, 3, Giovanni Raimondo1, 2
1Universitary Hospital of Messina, 2University Hospital of Messina, 3University Hospital of Messina

1477 Perceptions of the ‘cirrhotic coagulopathy’ influence low yield testing for cerebral hemorrhage in patients with cirrhosis and hepatic encephalopathy: an international, multi-specialty survey
Elliot B. Tapper1, Laura Mazer2
1Beth Israel Deaconess Medical Center, 2Beth Israel Deaconess Medical Center

1478 Prospective Multicenter Observational Study of Overt Hepatic Encephalopathy (OHE): Nomenclature and Disease Burden
Charles S. Landis1, Marwan Ghabril2, Vinod k. Rustgi3, Adrian M. Di Bisceglie4, Benedict Maliakkal5, Don C. Rockey6, John M. Vierling7, Richard Rowell 8, Michael Santoro8, Aimee Enriquez8, Marzena Jurek 8, Masoud Mokhtarani8, Dion F. Coakley8, Bruce F. Scharschmidt8
1University of Washington, 2Indiana University, 3University of Pittsburgh, 4St Louis University, 5University of Rochester, 6Medical University of South Carolina, 7Baylor College of Medicine , 8Horizon Therapeutics (formerly Hyperion Therapeutics, Inc.)

1479 Sarcopenia predicts moratility after transjugular intrahepatic portosystemic shunt placement
Joshua Anderson1, 3, Alagappan A. Annamalai1, Joseph L. Robinson1, Tram T. Tran1, Walid S. Ayoub1, Jonah Hirschbein2, Georgios Voidonikolas1, Irene K. Kim1, Vladamir Donchev1, Nicholas N. Nissen1, Andrew S. Klein1, Vinay Sundaram1
1Cedars-Sinai Medical Center, 2Univeristy of California Davis Medical Center, 3University of Florida Health Science Center

1480 Myocardial blood flow is reduced in patients with compensated cirrhosis even in the absence of a hyperdynamic circulation
Claire Grant1, 2, Charlotte E. Buchanan1, Eleanor Cox1, Huda Mahmoud1, 2, Andrew Austin2, Susan Francis1, Chris McIntyre1
1University of Nottingham, 2Royal Derby Hospital

1481 Sarcopenia and Sarcopenic-Obesity are Associated with Hyperammonemia and Increased Risk of Hepatic Encephalopathy in Cirrhotics
Aldo J. Montano-Loza1, Andres Duarte-Rojo2, Rahima A. Bhanji1, Christopher F. Rose3
1Univ of Alberta, 2University of Arkansas for Medical Sciences, 3Université de Montréal CRCHUM

1482 Acute decompensation of cirrhosis requiring hospitalisation is not fully reversibile and defines future organ specific decompensation
Rosaria Spinella, Rohit Sawhney, Peter Holland-Fischer, Naina Shah, Rajiv Jalan , Rajeshwar Mookerjee
UCL/Royal Free Hospital

1483 Progressive Loss of Hematopoietic Stem Cells and Associated Niche Cells in Advanced Cirrhosis
Chhagan Bihari, Sheetalnath B. Rooge, Dhananjay Kumar, Priyanka Saxena, Lovkesh Anand, Smriti Shubham, Archana Rastogi, Anupam Kumar, Shiv K. Sarin
Institute of Liver and Biliary Sciences

1484 Six minute walking test performance predicts cardiac dysfunction and mortality in liver cirrhosis
Carolina F. Pimentel1, 2, Ana Cristina A. Feldner1, Maria Lucia Ferraz1, Adriano m. Gonzalez1, 2, Michelle Lai3, Miguel Osman D. Aguiar5, Gabriel d. Branco5, Marcel Superbia5, Wilson Mathias4, Mario Kondo1
1Federal University of Sao Paulo, 2Euryclides de J Zerbini Transplant Hospital, 3Beth Israel Deaconess Medical Center, Harvard Medical School, 4University of Sao Paulo, 5Sao Luiz Hospital

1485 Development of a Novel Clinician Reported Outcome Tool for Assessment of Hepatic Encephalopathy
Jasmohan S. Bajaj1, 2, Nathan M. Bass3, R Todd Frederick4, Karin Coyne5, Mary Kay Margolis5, 6, Dion F. Coakley7, Masoud Mokhtarani7, Marzena Jurek 7, Bruce F. Scharschmidt7
1Virginia Commonwealth University, 2McGuire VA Hospital , 3University of California , 4California Pacific Medical Center, 5Evidera, 6Patient-Centered Outcomes Research Institute (PCORI), 7Horizon Therapeutics (formerly Hyperion Therapeutics, Inc.)

1486 Usefulness of Balloon-Occluded Retrograde Obliteration (B-RTO) as a Consolidation Procedure after Anticoagulation Therapy in Cirrhotic Patients with Portal Vein Thrombosis
Mie Inao, Kazuki Hirahara, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Satoshi Mochida
Saitama Medical University

1487 Osteopontin is a new prognostic marker of liver cirrhosis.
Radan Bruha1, Marie Jachymova2, Jaromir Petrtyl1, Karel Dvorak1, Martin Lenicek2, Petr Urbanek3, Libor Vitek2
1Charles University in Prague, 1st Faculty of Medicine, 2Charles University in Prague, 1st Faculty of medicine, 3Central Military Hospital

1488 Liver Injury Independently Predicts Incident Cardiovascular Disease (CVD) Risk
Kaku So-Armah1, Janet Tate3, 2, Joseph K. Lim2, Vincent Lo Re14, Vincent Marconi4, Jeffrey Samet1, Cynthia Gibert8, David Leaf9, 10, Adeel Butt6, 7, Matthew B. Goetz9, 10, David Rimland4, 11, Maria C. Rodriguez-Barradas12, 13, Matthew Budoff5, Chung-Chou Chang15, Amy Justice2, 3, Matthew Freiberg16
1Boston University School of Medicine, 2Yale University School of Medicine, 3VA Connecticut Healthcare System, 4Emory University School of Medicine, 5LA Biomed Research Institute, 6VA Pittsburgh Healthcare System, 7Hamad Healthcare Quality Institute and Hamad Medical Corporation, 8Washington DC VA Medical Center, 9David Geffen School of Medicine at UCLA, 10VA Greater Los Angeles Healthcare System, 11Atlanta VA Medical Center, 12Michael E. DeBakey VA Medical Center, 13Baylor College of Medicine, 14University of Pennsylvania School of Medicine, 15University of Pittsburgh Medical Center, 16Vanderbilt University School of Medicine

1489 Increasing frequency of gram-negative multi-drug resistant bacteria and Enterococcus faecium in spontaneous bacterial peritonitis and bacteremia in patients with decompensated cirrhosis
Alexandra Alexopoulou1, Larisa E. Vasilieva1, Sotiria Papadaki1, Danai Agiasotelli1, Sophia Pouriki1, Athanasia Tsiriga2, Marina G. Toutouza2, Spyros P. Dourakis1
1Medical School University of Athens, 2Microbiology Department Hippokration GNA

1490 Non-invasive assessment of portal hypertensive gastropathy: feasibility of contrast-enhanced ultrasonography for stomach wall
Hitoshi Maruyama, Soichiro Kiyono, Takayuki Kondo, Tadashi Sekimoto, Osamu Yokosuka
Chiba University Graduate School of Medicine

1491 Videogame Training Improves Brain Plasticity In Covert Hepatic Encephalopathy Through Changes In Brain Connectivity
Vishwadeep Ahluwalia, James Wade, Frederick G. Moeller, Joel L. Steinberg, Michael Lennon, Ariel Unser, Melanie White, Douglas M. Heuman, Edith A. Gavis, Jasmohan S. Bajaj
VCU and McGuire VAMC

1492 Preoperative plasma glucose level is a useful predictor of an improvement in hyperammonemia by occlusion of portosystemic shunts in cirrhotic patients with portal hypertension
Tsuyoshi Ishikawa, Ryo Sasaki, Tatsuro Nishimura, Yuki Aibe, Shogo Shiratsuki, Kazuhito Matsunaga, Takuya Iwamoto, Taro Takami, Isao Sakaida
Yamaguchi University Graduate School of Medicine

1493 Inadequate Food And Water Intake In Patients With Cirrhosis: Need Of A Personalized Nutritional Approach
Ferdinando A. Giannone1, 3, Marco Domenicali1, 3, Maurizio Baldassarre1, 3, Paola De Pasquale1, Silvia Boffelli1, 2, Maristella Laggetta1, 3, Maurizio Biselli1, 2, Mauro Bernardi1, 2, Paolo Caraceni1, 3
1Alma Mater Studiorum University of Bologna, 2Azienda Ospedaliero-Universitaria di Bologna - Policlinico S. Orsola-Malpighi, 3Alma Mater Studiorum University of Bologna

1494 Myocardial strain as a noninvasive measure of circulatory dysfunction and systolic function in liver cirrhosis.
Carolina F. Pimentel1, 4, Maria Lucia Ferraz1, Miguel Osman D. Aguiar2, Adriano m. Gonzalez1, 2, Gabriel d. Branco2, Marcel Superbia2, Ana Cristina A. Feldner1, Michelle Lai5, Wilson Mathias3, Mario Kondo1
1Federal University of Sao Paulo, 2Sao Luiz Hospital, 3University of Sao Paulo, 4Euryclides de J Zerbini Transplant Hospital , 5Beth Israel Deaconess Medical Center, Harvard Medical School

1495 Autonomic cardiac dysfunctions are common in cirrhotic patients and may be associated with an increased mortality.
Carolina F. Pimentel1, 5, Ricardo Salvadori2, Ana Cristina A. Feldner1, Adriano m. Gonzalez1, 5, Miguel Osman D. Aguiar3, Gabriel d. Branco3, Marcel Superbia3, Michelle Lai6, Maria Lucia Ferraz1, Wilson Mathias4, Mario Kondo1
1Federal University of Sao Paulo, 2Sao Luiz Hospital, 3Sao Luiz Hospital, 4University of Sao Paulo, 5Euryclides de J Zerbini Transplant Hospital, 6Beth Israel Deaconess Medical Center, Harvard Medical School

1496 Low Serum Leptin Level Is A Biomarker For Malnutrition In Hospitalized Patients With Cirrhosis
Vikrant Rachakonda, Jaideep Behari
University of Pittsburgh

1497 The World Congress of Gastroenterology Guidelines for the Diagnosis of Left Ventricular Diastolic Dysfunction Differ from the American Society of Echocardiography Standard Recommendation
Thoetchai Peeraphatdit1, 2, Niyada Naksuk3, Lewis R. Roberts2, Roongruedee Chaiteerakij2, 4
1University of Minnesota, 2Mayo Clinic College of Medicine, 3Mayo Clinic College of Medicine, 4Chulalongkorn University

1498 Transjugular Liver Biopsy Is Safe In Sickle Cell Disease and Provides Insight into Hepatopathy
David M. Chascsa1, Ohad Etzion2, Hawwa Alao2, Courtney Fitzhugh3, John F. Tisdale3, Caterina Minniti3, Matthew Hsieh3, David E. Kleiner4, Ahmed M. Gharib1, Varun K. Takyar2, Jason L. Eccleston2, Theo Heller2, Christopher Koh2
1National Institutes of Health, 2NIDDK, 3NIH, 4NIH

1499 A half of hepatic hydrothorax in cirrhotic patients were caused by porous diaphragm syndrome due to radiofrequency ablation for hepatocellular carcinoma
Kenichi Miyoshi, Masahiko Koda, Toshiaki Okamoto, Tomomitsu Matono, Takaaki Sugihara, Keiko Hosho, Jun-ichi Okano
Tottori University School of Medicine

1500 Sarcopenic obesity impairs prognosis of patients with cirrhosis
Motoh Iwasa, Ryosuke Sugimoto, Yoshinao Kobayashi, Yoshiyuki Takei
Mie University Graduate School of Medicine

1501 Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis
Jonathan G. Stine1, Puja M. Shah2, Scott L. Cornella3, Sean R. Rudnick1, George R. Stukenborg4, Patrick Northup1
1University of Virginia, 2University of Virginia, 3University of Virginia, 4University of Virginia

1502 Minimal hepatic encephalopathy diagnosed by Psychometric Hepatic Encephalopathy Score (PHES) or critical flicker frequency (CFF) is associated with progression of liver cirrhosis
Jerzy Jaroszewicz, Agnieszka Stawicka, Justyna Zbrzezniak, Natalia Kilisinska, Aleksandra Swiderska, Tadeusz W. Lapinski, Robert Flisiak
Medical University of Bialystok

1503 Real Time Pressure Volume Loops in Cirrhosis: Characterization of Systolic and Diastolic Function and Validation of Doppler Indices with the Gold Standard
Cristina Ripoll2, 1, Raquel Yotti3, Yolanda Benito3, Diego Rincón2, Maria Vega Catalina2, Jaime Elizaga3, Javier Bermejo3, Rafael Bañares2
1Martin-Luther-Universität Halle-Wittenberg, 2Hospital Universitario Gregorio Marañón, IiSGM. CiberEHD, 3Hospital General Universitario Gregorio Marañón, IiSGM

1504 Validation of Relationship between Variation in the Promoter Region of Glutaminase Gene and Development of Hepatic Encephalopathy in East Asian
Jem Ma Ahn, Soon Ho Um, Tae Hyung Kim, Sun Young Yim, Eun Sun Kim, Bora Keum, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon . Yim, Yoon Tae Jeen, Jong Eun Yeon, Hong Sik Lee, Hoon Jai Chun, Kwan Soo Byun, Chang Duck Kim, Ho Sang Ryu
Korea University College of Medicine

1505 Comparison Of Thrombin Generation After Addition Of Thrombomodulin Or Activated Protein C: Looking For A Marker Of Hypercoagulability With Low Variability In Patients With Cirrhosis.
Cédric Duron1, Armando Abergel1, Géraldine Lamblin1, Aurelien Lebreton2, Thomas Sinegre3
1CHU, 2CHU Clermont Ferrand, 3CHU Clermont Ferrand

1506 In Vivo Assessment Of Portal Hypertensive Colopathy And Clinical Outcome Of Patients With Liver Cirrhosis With Confocal Laser Endomicroscopy (CLE)
Steffen Zopf1, Gian Eugenio Tontini2, Michael Vieth3, Markus F. Neurath1, Helmut Neumann1
1Friedrich-Alexander University of Erlangen, 2IRCCS Policlinico San Donato, 3Klinikum Bayreuth

1507 Conjugated bile acids suppress the HPA axis via activation of hypothalamic glucocorticoid receptors in a rodent model of chronic biliary obstruction
Matthew McMillin1, 2, Gabriel A. Frampton1, Stephanie Grant1, Matthew A. Quinn3, Sharon DeMorrow2, 1
1Texas A&M Health Science Center, College of Medicine, 2Central Texas Veterans Healthcare System, 3National Institute of Environmental Health Sciences, NIH

1508 Characteristics, indications and outcomes in cirrhotic patients with portal hypertension undergoing endoscopic retrograde cholangiography: a case-control study
Ricardo Macías-Rodríguez, Jose Luis Rodriguez-Garcia, Astrid Ruiz-Margáin, Aldo Torre
INCMNSZ

1509 Efficacy of Ornithine Phenylacetate (OP) in lowering plasma ammonia after upper gastrointestinal bleeding (UGIB) in cirrhotic patients: a multicenter, randomized, double blind trial
Meritxell Ventura-Cots1, German Soriano3, 4, Macarena Simon-Talero1, Maria Torrens1, Albert Blanco2, Jose Antonio Arranz2, Mar Concepción3, Edilmar A. Alvarado3, Cristina Gely3, Eva Roman3, Joan Genescà1, 4, Juan Cordoba1, 4
1Hospital Vall d'Hebron, 2Hospital Vall d'Hebron , 3Hospital de la Santa Creu i Sant Pau, 4CIBEREHD

1510 Ammonemia predicts severity and outcome in cirrhotic patients with hepatic encephalopathy
Simona Tripon2, 1, Maxime Mallet2, 1, Marika Rudler2, 1, Denis Monneret2, 4, Francoise Imbert-Bismut2, 4, Thierry Poynard2, 1, Nicolas Weiss2, 3, Dominique Thabut2, 1
1AP-HP, hôpital Pitié-Salpêtrière, 2Brain-Liver Pitié-Salpêtrière Study Group (BLIPS), Hôpital de la Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris,, 3Unité de réanimation neurologique, Fédération de Neurologie 1, Pôle des maladies du système nerveux, Hôpital de la Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, 4Service de biochimie, Hôpital de la Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris,

1511 Use of betablockers, previous hepatic encephalopathy and low albumin levels as risk factors of portal vein thrombosis in a cohort of cirrhotic patients
Marta Lopez Gomez1, Elba Llop1, Angela Puente2, Juan de la Revilla1, Carlos Fernández-Carrillo1, Fernando Pons1, Jose Luis Martinez1, Natalia Fernández1, Maria Trapero1, Javier Crespo2, José Luís Calleja1
1Hospital Universitario Puerta de Hierro (MADRID. SPAIN), 2Hospital Universitario Marqués de Valdecilla

1512 The burden of osteoporotic hip and spine fractures in elderly patients with cirrhosis
Arpan A. Patel2, Omer Shah1, Sammy Saab2, Vinay Sundaram1
1Cedars-Sinai Medical Center, 2University of California at Los Angeles

1513 Role of 100 % FiO2 PaO2 and macroaggregated albumin scan in predicting outcomes in HPS patients considered for MELD exception
Sachin Batra, Rajasekhar Tanikella, Nathaniel P. Avila, Meera B. Avila, ASHA kuruvilla, Shivang Mehta, Shaheryar Siddiqui, Victor I. Machicao, Michael B. Fallon
University of Texas Health Science at Houston

1514 Proliferative lymphangiogenic endothelial cells are regulated by caveolin-1 and vascular endothelial growth factor receptor(VEGFR)-3 in human cirrhotic liver
Hiroaki Yokomori1, Masaya Oda2
1Kitasato University Medical Center, 2 International University of Health and Welfare

1515 Relative Adrenal Insufficiency in Patients with Alcoholic Cirrhosis : Multicenter Prospective Study in Gangwon Province, South Korea
Young Don Kim1, Dae Hee Choi2, Ki Tae Suk4, Moon Young Kim3, Gab Jin Cheon1, Soon Koo Baik3, Dong Joon Kim4
1University of Ulsan College of Medicine, 2Kangwon Natl Univ, 3Yonsei University Wonju college of medicine, 4Hallym University College of Medicine

1516 Linkage and interaction between portal hemodynamics and serum sodium concentration in cirrhosis
Hitoshi Maruyama, Takayuki Kondo, Tadashi Sekimoto, Soichiro Kiyono, Osamu Yokosuka
Chiba University Graduate School of Medicine

Experimental Studies in Cirrhosis and Portal Hypertension

1517 Ammonia Produces Pathological Changes And Activation In Human Hepatic Stellate Cells And Is A Target For Therapy In Portal Hypertension
Francesco De Chiara, Rajiv Jalan , Vairappan Balasubramaniyan, Fausto Andreola, Massimo Malago, Massimo Pinzani, Rajeshwar Mookerjee, Krista Rombouts
UCL

1518 Simvastatin prevents the aggravation of hepatic microvascular dysfunction caused by endotoxemia in cirrhotic rats
Dinesh M. Tripathi, Erica Lafoz, Hector Garcia-Caldero, Juan Carlos Garcia-Pagan, Jordi Gracia-Sancho, Jaime Bosch
IDIBAPS - Hospital Clinic de Barcelona - CIBEREHD

1519 Inflammation and hypoxia regulate RAGE, NF-kB und pERK via Glyoxalase I and Methylglyoxal in sinusoidal endothelial cells: a possible mechanism in development of cirrhosis
Marcus Hollenbach, Antje Thonig, Sabine Pohl, Maurice Michel, Cristina Ripoll, Robin A. Greinert, Patrick Michl, Alexander Zipprich
Martin-Luther University Halle-Wittenberg

1520 Enoxaparin treatment does not ameliorate liver fibrosis or portal hypertension in experimental models of cirrhosis in rats.
Jose Ignacio Fortea1, Alexander Zipprich3, Carolina Fernandez Mena1, Christopher F. Rose4, Juan Bañares1, Marta Puerto1, 2, Cristina R. Bosoi4, Jorge Almagro1, Marcus Hollenbach3, Marc-André Clément4, Javier Vaquero1, 2, Rafael Bañares1, 2, Cristina Ripoll1, 3
1Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 2CIBERehd, 3Martin-Luther-Universität Halle-Wittenberg, 4CRCHUM - Université de Montréal

1521 Neuro-inflammation in Cirrhotic Mice is Dependent on Gut Microbial Colonization: Implications for Hepatic Encephalopathy
Dae Joong Kang1, Siddhartha Ghosh1, Daniel Carl1, Arun J. Sanyal1, Ryan B. Sartor2, Phillip B. Hylemon1, Huiping Zhou1, Runping Liu1, Xiang Wang1, Jing Yang1, Chunhua Jiao1, Jasmohan S. Bajaj1
1VCU and McGuire VAMC, 2University of North Carolina

1522 Emricasan, a pan caspase inhibitor, improves survival and portal hypertension in a murine model of long-term common bile-duct ligation
Akiko Eguchi1, Alexander Wree1, Yukinori Koyama1, Casey Johnson1, Ryota Nakamura1, Patricia C. Contreras2, Ariel E. Feldstein1
1UCSD, 2Conatus Pharmaceuticals

1523 Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats.
Cristina R. Bosoi2, 1, Mariana M. Oliveira2, 1, Marc-André Clément2, 1, Mélanie Tremblay2, Gabriella A. Ten Have3, Nicolaas E. Deutz3, Christopher F. Rose2, 1
1Université de Montréal, 2CRCHUM, 3 Texas A&M University

1524 The Evaluation of Portal Hypertension using Quantitative Magnetic Resonance Imaging
Naaventhan Palaniyappan1, Eleanor Cox2, Andrew Austin3, Indra Neil Guha1, Susan Francis2, Guruprasad P. Aithal1
1Nottingham University Hospitals NHS Trust and University of Nottingham, 2University of Nottingham, 3Derby Teaching Hospitals NHS Foundation Trust

1525 The soluble guanylyl cyclase stimulator riociguat reduces liver fibrosis and portal pressure in cirrhotic rats
Philipp Schwabl1, Ksenia Brusilovskaya1, Florian Riedl1, David J. Bauer1, Bastian Strobel1, Paul Supper1, Hubert Hayden1, Michael Trauner 1, Bruno K. Podesser2, Katharina Wochner2, Markus Peck-Radosavljevic1, Thomas Reiberger1
1Medical University of Vienna, 2Medical University of Vienna

1526 Portal tract fibrosis is induced by hepatic arterial buffer response in portal hypertensive rats: A role for macrophage miR154 released via exosome
Li Gong1, 2, Chao Dong1, 3, Teruo Utsumi1, Yasuko Iwakiri1
1Yale University School of Medicine, 2The third Xiangya Hospital, Central South University, 3Xiangya Hospital, Central South University

1527 Diabetes is Associated with Stool and Sigmoid Mucosal Microbiota Dysbiosis Independent of MELD score in Cirrhosis: Implications for Prognostication
Jasmohan S. Bajaj1, Naga Betrapally2, Douglas M. Heuman1, Melanie White1, Kalyani Daita1, Ariel Unser1, Edith A. Gavis1, Phillip B. Hylemon1, Swati S. Almeida-Dalmet2, Masoumeh Sikaroodi2, Patrick M. Gillevet2
1VCU and McGuire VAMC, 2George Mason University

1528 L-carnitine prevents ammonia–induced cytotoxicity on human astrocytes: Results of metabolome analysis
Kazuyuki Suzuki1, 2, Ting Wang2, Keisuke Kakisaka2, Kei Sawara2, Hidekatsu Kuroda2, Mio Onodera2, Ryujin Endo 2, Akinobu Kato3, 2, Yasuhiro Takikawa2
1Morioka University, 2Division of Hepatology, 3Morioka Municipal Hospital

1529 Elevated galectin-3 in cirrhotic heart increases TNFa and inhibits cardiac contractility in rats
Hongqun Liu, Samuel S. Lee
university of calgary

1530 ELF™ and Angiopoietins accurately predict clinically significant portal hypertension
Brian J. Hogan2, Ioanna Parisi1, David W. Patch1, Dominic Yu3, Amar P. Dhillon4, Andrew R. Hall4, Ankur Srivastava2, Paul M. Trembling2, Sudeep Tanwar2, Julie Parkes2, Timothy Meyer5, William M. Rosenberg2, James O'Beirne2, 1
1Royal Free London NHS Foundation Trust, 2University College London, 3Royal Free London NHS Foundation Trust, 4Royal Free London NHS Foundation Trust, 5University College London

1531 Adipose Tissue-Specific ATGL Deletion Does Not Protect Against Cachexia Development In Bile Duct Ligated Mice
Vikrant Rachakonda, Erin E. Kershaw, Jaideep Behari
University of Pittsburgh

1532 Liver NK cells from NLG4-/- mice inhibit progressions of hepatocellular carcinoma of C57BL/6 mice model through decrease in p53 and Akt expressions
Johnny Amer, Ahmad Salhab, Rifaat Safadi
Hadassah-Hebrew University Hospital

1533 Usefulness of spleen stiffness measurement using VTQ in diagnosing esophagogastric varices including the relationship with collateral vessels
Chikage Nakano1, Takashi Nishimura1, Tomoko Aoki2, 1, Kyohei Kishino1, Yoshihiro Shimono1, Kunihiro Hasegawa1, Ryo Takata1, Kazunori You1, Akio Ishii1, Tomoyuki Takashima1, Yoshiyuki Sakai1, Nobuhiro Aizawa1, Naoto Ikeda1, Hiroki Nishikawa1, Yoshinori Iwata1, Hirayuki Enomoto1, Shuhei Nishiguchi1, Hiroko Iijima1
1Hyogo College of Medicine, 2Yoka hospital

Health Economics and Cost Effectiveness of Viral Hepatitis

1534 All-oral direct acting antivirals can offer significant cost savings and cost effectiveness for treating hepatitis C in medically underserved areas in the United States: Impact of task-shifting on access
Channa R. Jayasekera1, Nathaniel Smith2, Ryan B. Perumpail1, Robert J. Wong3, Rachel Beckerman2, Zobair M. Younossi4, 5, Aijaz Ahmed1
1Stanford University Medical Center, 2CB Partners, 3Alameda County Health System - Highland Hospital, 4Inova Fairfax Hospital, 5Inova Health System

1535 Inappropriate Laboratory Utilization: Acute Viral Hepatitis Serologies
Kamran Hussaini1, Muhammad B. Hammami1, Edward Charbek4, 1, Robin Chamberland2, Hamza Khalid3, 1, Brent A. Neuschwander-Tetri3, 1
1Saint Louis University, 2Saint Louis University, 3Saint Louis University, 4Saint Louis University

1536 Cost-effectiveness analysis of sofosbuvir plus ledipasivir in the treatment of chronic hepatitis C virus genotype 1 infection in real life practice in China
Bing Li1, Jing Chen2, Cheng Wang2, 3, Vanessa Wu2, April Wong2, Qing Shao1, Dong Ji1, Fan Li1, Yudong Wang2, Xiaoxia Niu1, Jialiang Liu1, Wucai Yang1, Yiming Fu1, Guofeng Chen1, George K. Lau2
1302 Hospital, 2Humanity & Health Medical Group, 3Nanfang Hospital, Southern Medical University

1537 Cost-effectiveness analysis of sofosbuvir-based regimens for chronic hepatitis C virus genotype 1 infection in China
Fan Li1, Guofeng Chen1, Qing Shao1, Dong Ji1, Bing Li1, Zhongbin Li1, Jialiang Liu1, Chunxiao Liu1, Tingting Wang1, Qiaomin Wang1, Jing Chen2, Vanessa Wu2, April Wong2, Cheng Wang2, Yudong Wang2, George K. Lau1, 2
1302 Hospital, 2Humanity & Health Medical Group

1538 The Value of Cure Associated with Treating Treatment-naïve (TN) Chronic Hepatitis C (CH-C) Genotype 1 (GT1): Are the New All Oral Regimens a Good Value to Society?
Zobair M. Younossi1, 2, Haesuk Park3, Douglas Dieterich4, Sammy Saab5, Aijaz Ahmed6, Stuart C. Gordon7
1Inova Fairfax Hospital, 2Inova Health System, 3University of Florida, 4Icahn School of Medicine at Mount Sinai, 5University of California Los Angeles, 6Stanford University, 7Henry Ford Hospital

1539 Rethinking pricing policy of direct antiviral agents to cure chronic hepatitis C infection at a population-level
Francois Girardin, Nathalie Vernaz, Nicolas Goossens, Francesco Negro
Geneva University Hospital

Hepatitis B: Epidemiology and Natural History

1540 Hepatocellular Carcinoma Incidence In Chronic Hepatitis B Patients Under Long-Term Treatment With Entecavir And Tenofovir
Helder Cardoso1, 2, Rui Gaspar1, 2, Marco Silva1, 2, Ana Vale1, 2, Guilherme Macedo1, 2
1Centro Hospitalar S. João, 2Faculty of Medicine of the University of Porto

1541 Is there any rule for antiviral therapy in HBV-related compensated cirrhosis patients with serum HBV DNA undetectable or at low levels and normal ALT?
Taotao Yan1, Xiaoying Sha3, Jing Wang1, Li Jin1, Yu Zhang2, Ruitian Yi1, Furong Cao1, Yuan Yang2, Jinfeng Liu2, Yingli He2, Tianyan Chen2, Yingren Zhao2
1Xi'an Jiaotong Univercity, 2The First Affiliated Hospital of Xi'an Jiaotong Univercity, 3Eighth hospital of Xi'an

1542 Comparing antiviral efficacy of Tenofovir monotherapy and Tenofovir based combination therapy in antiviral resistant chronic hepatitis B: A interim result of multicenter cohort study
Kyu Sik Chung1, Beom Kyung Kim1, Ki Tae Yoon2, Hana Park3, Chang Wook Kim4, Jin-Woo Lee5, Young Seok Kim6, Jung Il Lee7, Jun Yong Park1, Seung Up Kim1, Do Young Kim1, Sang Gyune Kim6, Young-Joo Jin5, Hee Yeon Kim4, Seong Gyu Hwang3, Mong Cho2, Kwan Sik Lee7, Kwang-Hyub Han1, Sang Hoon Ahn1
1Yonsei University College of Medicine, 2Pusan National University School of Medicine, 3CHA Bundang Medical Center, 4The Catholic University of Korea College of Medicine, 5Inha University College of Medicine, 6Soonchunhyang University College of Medicine, 7Gangnam Severance Hospital

1543 Hepatitis B virus infection in irregular and refugee migrants in Naples, Italy.
Nicola Coppola1, Loredana Alessio1, Luciano Gualdieri2, Mariantonietta Pisaturo3, Caterina Sagnelli4, Nunzio Caprio5, Carmine Minichini1, Mario Starace1, Giuseppe Signoriello1, Giuseppe Pasquale1, Evangelista Sagnelli1
1Second University of Naples, 2Medical Center, Centro per la Tutela della Salute degli Immigrati, 3Medical Center, Centro di Accoglienza “La tenda di Abramo”, 4Medical Center, Centro Sociale ex Canapificio, 5Medical center, Centro Suore Missionarie della Carità

1544 Four years real-life experience with antiviral adherence in chronic hepatitis B infection in a tertiary university hospital
Rodrigo M. Abreu1, 2, Leda C. Bassit3, Sijia Tao3, Yong Jiang3, Denise Paranaguá-Vezozzo1, Raymond F. Schinazi3, Flair J. Carrilho1, Suzane K. Ono1
1University of São Paulo School of Medicine, 2Clinical Hospital, University of São Paulo School of Medicine, 3Emory University School of Medicine, and Veterans Affairs Medical Center

1545 Factors Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance
James Fung, Ching-Lung Lai, Danny Wong, Wai-Kay Seto, Man-Fung Yuen
University of Hong Kong

1546 Assessing the impact of hepatitis B immune globulin (HBIG) on responses to the hepatitis B vaccine during co-administration
Qingwen Cui1, Iryna Zubkova1, Trudy Murphy2, Sarah F. Schillie2, Marian E. Major1
1CBER/FDA, 2Centers for Disease Control and Prevention

1547 End-of-therapy Serum Gradient of Hepatitis B Surface Antigen Predicts Off-therapy Durability after Discontinuation of Nucleos(t)ide Analogues
Yao-Chun Hsu1, 2, Chun-Ying Wu3, Chi-Yang Chang1, Ming-Shiang Wu7, Jia-Horng Kao4, Tzeng-Huey Yang5, Hsu-Wei Hung8, Jaw-Town Lin6
1E-Da Hospital, 2I-Shou University, 3Taichung Veterans General Hospital, 4National Taiwan University, 5Lotung Poh-Ai Hospital, 6Fu Jen Catholic University, 7National Taiwan University, 8Taipei Institute of Pathology

1548 Liver fibrosis progression, new-onset metabolic syndrome and risk of hepatocellular carcinoma in chronic hepatitis B – an 8-year prospective cohort study of 1,178 patients with paired transient elastography examination
Grace LH Wong, Henry Lik-Yuen Chan, Angel ML Chim, Vincent W. Wong
Institute of Digestive Disease, The Chinese University of Hong Kong

1549 High Rates of Surface Antigen Loss and Low Rates of Seroreversion in Asian Chronic Hepatitis B Patients Treated with Oral Antiviral Therapy: Community-Based Real World Outcomes
Robert J. Wong1, My T. Nguyen2, Huy N. Trinh3, Andrew Huynh2, Mytop Ly2, Huy Nguyen3, Khanh Nguyen3, Jenny D. Yang3, Ruel Garcia3, Brian S. Levitt3, Eduardo DaSilvera3, Robert Gish4
1Alameda Health System - Highland Hospital, 2Silicon Valley Research Institute, 3San Jose Gastroenterology, 4Stanford University Medical Center

1550 The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy
Wai-Kay Seto, Danny Wong, Sze Hang Kevin Liu, James Fung, Ching-Lung Lai, Man-Fung Yuen
The University of Hong Kong, Queen Mary Hospital

1551 Mapping HBsAg epitope profiles to predict HBsAg loss/seroconversion in a treatment naïve cohort of genotype A chronic hepatitis B (CHB) patients receiving tenofovir disoproxil fumarate (TDF) therapy
Renae Walsh1, Rachel Hammond1, Lilly Yuen1, Julianne Bayliss1, Peter A. Revill1, Thomas Leary2, Howard Thomas3, Anuj Gaggar4, Mani Subramanian4, Kathryn M. Kitrinos4, Alex J. Thompson5, Stephen Locarnini1
1Victorian Infectious Diseases, 2Abbott Laboratories, 3Imperial College London , 4Gilead Sciences, 5St Vincents Hospital

1552 Comparison between spontaneous and post-nucleos(t)ide analogue HBsAg seroclearance in chronic HBV infection
Yi-Cheng Chen, Rachel Wen-Juei Jeng, Rong-Nan Chien, Chia-Ming Chu, Yun -Fan Liaw
Chang Gung Memorial Hospital

1553 Different DNA methylation patterns by viral status in liver cancer
Min-Ae Song2, 4, Sandi Kwee3, Maarit Tiirikainen2, Gordon S. Okimoto2, Brenda Y. Hernandez2, Linda L. Wong2, 1, Naoky CS C. Tsai2, Herbert Yu2
1Univ of Hawaii School of Medicine, 2University of Hawaii, 3Queens Medical Center, 4Ohio State University

1554 Detection of genetic and epigenetic DNA markers in urine for the early detection of primary and recurrent hepatocellular carcinoma
Hie-Won Hann1, Surbhi Jain2, Selena Lin7, Sooji Yi1, Ting-Tsung Chang3, Chi-Tan Hu4, Wei Song2, Ying-Hsiu Su5
1Thomas Jefferson University Hospital, 2JBS Science, Inc, 3National Cheng Kung Universtiy Medical College, 4Buddhist Tzu Chi General Hospital and Tzu Chi University, 5The Baruch S. Blumberg Institute, 7Drexel University College of Medicine

1555 Prevalence and serological features of chronic hepatitis B patients with concurrent HBsAg and anti-HBs in the Hepatitis B Research Network (HBRN).
William M. Lee1, Yona K. Cloonan2, Kathleen B. Schwarz3, Doan Y. Dao1, Anna S. Lok4
1University of Texas Southwestern Medical Center at Dallas, 2University of Pittsburgh, 3Johns Hopkins University School of Medicine, 4University of Michigan

1556 Clinical Outcomes of Patients with Private vs. Public Drug Coverage for Treatment of Chronic Hepatitis B
Aman V. Arya, Mayur Brahmania, Matthew Kowgier, Hemant Shah, Orlando Cerocchi, David K. Wong, Jordan J. Feld, Harry L. Janssen
University of Toronto

1557 Increased Viral Diversity is Associated with Baseline Serology and Reduced Serological Response to Nucleos(t)ide Analogue (NA) Treatment During the Immune Clearance Phase of Chronic Hepatitis B
Julianne Bayliss1, Lilly Yuen1, Gillian Rosenberg1, Alex J. Thompson2, Anuj Gaggar3, Kathryn M. Kitrinos3, Mani Subramanian3, Patrick Marcellin4, Edward J. Gane5, Henry Lik-Yuen Chan6, Xin Li1, Danni Colledge1, Scott Bowden1, Stephen Locarnini1, Peter A. Revill1
1VIDRL, 2St Vincent's Hospital, 3Gilead Sciences, 4University of Paris, 5Auckland City Hospital, 6Chinese University of Hong Kong

1558 Long term clinical outcome in chronic hepatitis B patients with partial virologic response to entecavir treatment
Kyu Sik Chung, Hye Won Lee, Jun Yong Park, Hye Jin Ku, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn
Yonsei University College of Medicine

1559 Genotype-Specific Prevalence and Importance of Naturally Occurring Precore-, Basal Core Promoter- and preS-Mutations in a Large European Study Cohort of Patients Chronically Infected with Hepatitis B Virus
Lisa Sommer1, Kai-Henrik Peiffer1, Julia Dietz1, Simone Susser1, Joerg Petersen2, Peter Buggisch2, Markus Cornberg3, Stefan Mauss4, Hartwig Klinker5, Martin F. Sprinzl6, Florian van Bömmel7, Eberhard Hildt8, Caterina Berkowski1, Dany Perner1, Sandra Passmann1, Stefan Zeuzem1, Christoph Sarrazin1
1J. W. Goethe University Hospital, 2IFI-Institut an der Asklepiosklinik St. Georg, 3Hannover Medical School, 4Center for HIV and Hepatogastroenterology, 5University of Wuerzburg Medical Center , 6Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 7University Hospital Leipzig, 8Paul-Ehrlich-Institut

1560 Individualizing Hepatitis B Prophylaxis in Liver Transplant (LT) Recipients: Diminished Need for Hepatitis B Immunoglobulin (HBIG)
Kavita Radhakrishnan1, Aileen Chi2, David J. Quan2, John P. Roberts3, Norah Terrault2
1UCSF, 2UCSF, 3UCSF

1561 Lower Incidence of Hepatocellular Carcinoma (HCC) with Antiviral Therapy in Chronic Hepatitis B (CHB) Patients without Cirrhosis and Normal to Minimally Elevated Alanine Aminotransferase (ALT) Levels (< 2x upper limit of normal or ULN)
Joseph K. Hoang1, Nghia H. Nguyen2, 1, Hwai-I Yang3, 8, Derek Lin4, Vinh D. Vu1, Kevin T. Chaung1, Vincent G. Nguyen1, An K. Le1, Huy N. Trinh5, Jiayi Li6, Jian Q. Zhang7, Chien-Jen Chen3, 9, Mindie H. Nguyen1
1Stanford University Medical Center, 2University of California San Diego, 3Academia Sinica, 4Stanford University Medical Center, 5San Jose Gastroenterology, 6Palo Alto Medical Foundation, 7Chinese Hospital, 8National Yang-Ming University, 9National Taiwan University

1562 Targetting HNF4a via Activating Extracellular Signal-Regulated Kinase(ERK) Pathway to inbibit HBV replication by Luteolin
Yunhong Nong1, 2, Ying Shi1, 2, Miao Liu1, Libo Yan1, Yong Lin3, Lang Bai1, Hong Tang1
1West China Hospital, Sichuan University, 2Division of Infectious Diseases, 3Molecular Biology and Lung Cancer Program

1563 Redefining the Natural History of Chronic Hepatitis B: Using Viral Diversity to Classify Disease and Predict Serological Response to Nucleos(t)ide Analogue (NA) Therapy
Julianne Bayliss1, Gillian Rosenberg1, Lilly Yuen1, Anuj Gaggar2, Kathryn M. Kitrinos2, Mani Subramanian2, Edward J. Gane3, Henry Lik-Yuen Chan4, Rachel Hammond1, Scott Bowden1, Peter A. Revill1, Stephen Locarnini1, Alex J. Thompson5
1VIDRL, 2Gilead Sciences, 3Auckland City Hospital, 4Chinese University of Hong Kong, 5St Vincent's Hospital

1564 Angiopoetin-like protein 2 independently associated with liver inflammation and fibrosis in patients chronically infected with hepatitis B virus
Hong Zhao, Yong-Qiong Deng, Gui-Qiang Wang
Peking University First Hospital

1565 PreS mutations analyzed by deep sequencing are correlated with the progression of liver diseases and HBsAg production.
Yuichiro Suzuki, Shinya Maekawa, Nobutoshi Komatsu, Mitsuaki Sato, Masaru Muraoka, Shuya Matsuda, Mika Miura, Yasuhiro Nakayama, Taisuke Inoue, Minoru Sakamoto, Nobuyuki Enomoto
University of Yamanashi

1566 Prevalence and Molecular Virology of Hepatitis Delta Virus in Australia
Kathy Jackson, Margaret Littlejohn, Lilly Yuen, Benjamin C. Cowie, Jennifer H. MacLachlan, Stephen Locarnini, Scott Bowden
Victorian Infectious Diseases

1567 Kinetics of Serum Hepatitis B Surface Antigen During the First Year of Tenofovir Treatment in Patients With Chronic Hepatitis B
Choong Kyun Noh, Soon Sun Kim, Sun Young Park, Joohan Park, Hyo Jung Cho, Jae Youn Cheong, Sung Won Cho
Ajou University School of Medicine

1568 The PAGE-B Score Stratifies Chronic Hepatitis B Patients with Compensated Cirrhosis at High Risk of Hepatocellular Carcinoma Development with Good Accuracy
Willem Pieter Brouwer1, Bettina E. Hansen1, Elena Raffetti2, Francesco Donato2, Giovanna Fattovich3
1Erasmus Medical Center Rotterdam, 2Institute of Hygiene, 3Azienda Ospedaliera Universitaria Integrata

1569 Health care disparity in delivering optimal care to chronic hepatitis B pregnant mothers.
Rasham Mittal, Amandeep K. Sahota
Kaiser Permanente Los Angeles Medical Center

1570 Ultrasound predicts steatosis in patients with chronic hepatitis B
Erin Kelly2, 1, Vickie A. Feldstein3, Rebecca Hudock1, Marion G. Peters1
1University of California San Francisco, 2University of Ottawa, 3UCSF

1571 Quantitative Hepatitis B surface antigen (qHBsAg) may define low-risk inactive carriers of CHB: Can this provide a framework for better management across all age-groups?
Navjyot K. Hansi1, Clara C. Seipt1, Upkar S. Gill1, Sandhia Naik2, William Tong3, Graham R. Foster1, Ivana Carey4, Patrick T. Kennedy1
1Blizard Institute, Barts and The London SMD, QMUL, 2Barts Health NHS Trust, 3Barts Health NHS Trust, 4Kings College London

1572 Baseline Hepatitis B core related antigen (HBcrAg) levels predict non-response to 96-weeks of Peg-Interferon treatment in HBV/HDV coinfected patients.
Benjamin Maasoumy1, Michael Wöbse1, Birgit Bremer1, Patrick Lehmann1, Benjamin Heidrich1, Svenja Hardtke1, Cihan Yurdaydin2, Michael P. Manns1, Markus Cornberg1, Heiner Wedemeyer1
1Hannover Medical School, 2Ankara University School of Medicine

1573 Application of Highly Sensitive Chemiluminescent Enzyme Immunoassay for Hepatitis B Surface Antigen to Detect Occult HBV infection: an Appropriate Method as Pre-Transfusion Testing.
Takako Inoue1, Noriyo Ochi1, Takaaki Goto1, Shintaro Ogawa2, Noboru Shinkai3, Kumiko Ohne1, Yukio Wakimoto1, Yasuhito Tanaka2, 1
1Nagoya City University Hospital, 2Nagoya City University Graduate School of Medical Sciences, 3Nagoya City University Graduate School of Medical Sciences

1574 Collaborative Public Health Efforts to Test and Link Foreign-Born Persons with Chronic Hepatitis B Virus Infection to Care
Aaron M. Harris, Ben Schoenbachler, Gilberto Ramirez, Claudia Vellozzi, Geoff Beckett
Centers for Disease Control and Prevention

1575 Hepatitis B viral load in dried blood spots: a validation study in Zambia
Michael J. Vinikoor1, 2, Samuel Zürcher3, Kalo Musukuma4, 2, Obert Kachuwaire2, Andri Rauch3, Benjamin Chi5, Meri Gorgievski3, Marcel Zwahlen3, Gilles Wandeler3
1University of North Carolina at Chapel Hill, 2Centre for Infectious Disease Research in Zambia, 3University of Bern, 4University of Zambia, 5University of North Carolina at Chapel Hill

1576 Utility of quantitative hepatitis B surface antigen (qHBsAg) testing for predicting maternal viremia associated with mother to child transmission of HBV in a multiethnic cohort of pregnant chronic hepatitis B (CHB) carriers in Canada
Golasa Samadi Kochaksaraei1, Carmen L. Charlton2, Stephen Congly1, Trudy Matwiy1, Eliana Castillo1, Steven R Martin3, Carla S. Coffin1
1University of Calgary, 2University of Alberta Hospital, 3University of Calgary

1577 Nationwide Prospective Survey in Japan to Clarify the Incidence of Viral Reactivation in Patients with Prior HBV Infection Receiving Immunosuppressive Agents
Masamitsu Nakao1, Nobuaki Nakayama1, Yoshihito Uchida1, Masashi Mizokami2, Satoshi Mochida1
1Saitama Medical University, 2National Center for Global Health and Medicine

1578 HBV-related cirrhosis in the Chronic Hepatitis Cohort Study (CHeCS)
Stuart C. Gordon2, 3, Loralee B. Rupp1, Joseph A. Boscarino4, Mark A. Schmidt5, Connie M. Trinacty6, Lois Lamerato7, Nancy Oja-Tebbe7, Mei Lu7
1Henry Ford Health System, 2Henry Ford Health System, 3Wayne State University, 4Geisinger Health System, 5Kaiser Permanente Northwest, 6Kaiser Permanente Hawaii, 7Henry Ford Health System

1579 HBsAg transferring from mother to infant through placenta account for non-response to hepatitis B vaccine in infant from HBsAg(+) mother
Jing Wang1, Jinfeng Liu2, Yingli He2, Dongfang Jin3, Yuan Yang2, Li Jin1, Taotao Yan1, Furong Cao1, Shulin Zhang2, Yingren Zhao2, Tianyan Chen2
1Xi'an Jiaotong University, 2The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China, 3Shaanxi Kangfu Hospital

1580 Aldehyde dehydrogenases-2 rs671 polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with hepatitis B virus
Jing Sun1, Hongqin Xu1, Xiuting He1, Jingyun Wang1, Xiaomei Wang1, Bin Gao2, Junqi Niu1, Yanhang Gao2
1The first hospital of Jilin University, 2National Institutes of Health NIH/NIAAA

1581 Clinical outcome of long-term entecavir therapy in patients with compensated and decompensated cirrhosis: Benefit for reversal of cirrhosis
Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn
Yonsei University College of Medicine

1582 Assessment of liver steatosis and its correlation with biochemical, elastographic and viral parameters in patients with chronic HBV infection after switching to tenofovir from any anti-HBV nucleos(t)ide analogue.
Krzysztof Tomasiewicz, Agnieszka Pokora-Pachowicz, Slawomir Kiciak
Medical University of Lublin

1583 Prevention of perinatal transmission of hepatitis B: A retrospective cohort study in China
Xiangjun Zhai1, Jie Jiang1, Jianfang Xu2, Yan Zou4, Shenglong Dai3, Liguo Zhu1, Hong Peng1
1Jiangsu provincial center for disease control and prevention , 2Danyang county center for disease control and prevention, 3Taixing county center for disease control and prewention, 4Zhangjiagang county center for disease control and prevention

1584 Changes in hepatitis B virus DNA concentration and assessment of hepatitis B surface antigen levels using two different quantitative assays during short-term entecavir therapy
Kazuma Shinkai, Hisashi Ishida, Ryousuke Kiyota, Taku Tashiro, Kentarou Nakagawa, Keisuke Fukutomi, Akio Ishihara, Tetsuya Iwasaki, Ryuichiro Iwasaki, Kumiko Nishio, Yuko Sakakibara, Takuya Yamada, Shoichi Nakazuru, Eiji Mita
National Hospital Organization Osaka National Hospital

1585 Hepatitis B Core-Related Antigen Level Decline in the First 12 Weeks of Peginterferon Treatment is Associated with Response in HBeAg-Negative Chronic Hepatitis B
Margo J. van Campenhout1, Willem Pieter Brouwer1, Vincent Rijckborst1, Robert J. de Knegt1, Andre Boonstra1, Harry L. Janssen2, 1, Bettina E. Hansen1, 3
1Erasmus MC University Medical Center Rotterdam, 2Toronto Western and General Hospital, University Health Network, 3Erasmus MC University Medical Center Rotterdam

1586 Hepatitis B Core-Related Antigen Levels are Inversely Correlated With Fibrosis Stage in HBeAg-Positive Chronic Hepatitis B
Margo J. van Campenhout1, Willem Pieter Brouwer1, Gertine van Oord1, Qing Xie4, Qin Zhang5, Fehmi Tabak6, Adrian Streinu-cercel7, Jiyao Wang8, Robert J. de Knegt1, Harry L. Janssen2, Andre Boonstra1, Bettina E. Hansen1, 3
1Erasmus MC University Medical Center Rotterdam, 2Toronto Western and General Hospital, University Health Network, 3Erasmus MC University Medical Center Rotterdam, 4Ruijin Hospital, Jiaotong University, 5Shanghai Public Health Center, Fu Dan University, 6Cerrahpasa Medical Faculty, 7National Institute of Infectious Diseases "Prof. Dr. Matei Bals", 8Zhong Shan Hospital, Fu Dan University

1587 Clinical Features of Chronic Hepatitis B (CHB) in Treatment-Naive Asian Patients with Positive HBeAg and Coexisting Pre-core and/or Basal Core Promoter (PC/BCP) Mutations
Calvin Q. Pan1, Erhei Dai2, Kalyan R. Bhamidimarri3, Zheng Zeng4, Paley Yin5
1NYU Langone Medical Center, NYU School of Medicine, 2The Fifth Hospital of Shijiazhuang, Hebei Medical University, 3University of Miami, Miami Transplant Institute, 4Peking University First Hospital, 5St. George’s University School of Medicine

1588 What is predicting post-pregnancy ALT flares?
Ivana Carey, Marie-Ange McLeod, Matthew J. Bruce, Mary Horner, Teresa Bowyer, Suman Verma, Vinod K. Audimoolam, Kath Oakes, Kosh Agarwal
Kings College School of Medicine at King's College Hospital

1589 Hepatic B flares in rheumatoid arthritis and psoriasis patients taking tumor necrosis factor blockers: a nationwide cohort study
Chun-Ying Wu1, 2, Yi-Ju Chen2, Jaw-Town Lin3
1Taichung Veterans General Hospital, 2National Yang-Ming University, 3Fu-Jen University

1590 The PAGE-B Score Accurately Predicts Clinical Outcome and Outperforms Other Biomarkers over 15 Years of Follow-up in a Diverse Cohort of Chronic Hepatitis B Patients
Willem Pieter Brouwer1, Adriaan J. van der Meer1, Andre Boonstra1, Elisabeth P. Plompen1, Suzan D. Pas1, Robert J. de Knegt1, Robert A. de Man1, Fiebo J. ten Kate1, Harry L. Janssen2, 1, Bettina E. Hansen1
1Erasmus Medical Center Rotterdam, 2UHN Liver Clinic

1591 Prediction of Clinical Outcomes in Hepatitis B E Antigen Negative Chronic Hepatitis B Patients with Elevated Hepatitis B Virus DNA Levels.
Jem Ma Ahn, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Samsung Medical Center, Sungkyunkwan University School of Medicine

1592 The Role of Surface Antibody in Hepatitis B Virus Reactivation in Patients with Resolved Infection: A Systematic Review and Meta-Analysis
Sonali Paul1, Aaron Dickstein1, Akriti P. Saxena1, Norma Terrin1, Kathleen Viveiros1, Ethan M. Balk2, John B. Wong1
1Tufts Medical Center, 2Brown University School of Public Health

1593 Serum Quantitative Levels of Hepatitis B Virus Core Antibody and Risk of Liver Cirrhosis and Hepatocellular Carcinoma-the R.E.V.E.A.L.-HBV Study
Mei-Hsuan Lee1, Chia-Lin Chang2, Jessica Liu2, Hui-Han Hu2, Chin-Lan Jen2, Sheng-Nan Lu3, Li-Yu Wang4, San-Lin You2, Pei-Jer Chen5, 6, Chien-Jen Chen2, 7
1Institute of Clinical Medicine, 2Genomics Research Center, 3Chang-Gung Memorial Hospital, 4MacKay College of Medicine, 5National Taiwan University, 6Division of Gastroenterology, Department of Internal Medicine, 7Graduate Institute of Epidemiology and Preventative Medicine

1594 Serum HBV RNA is an early marker for HBeAg seroconversion in treatment experienced patients receiving tenofovir disoproxil fumarate (TDF)-containing regimens
Florian van Bömmel2, Alexander Krauel2, Maria Grossmann2, Kathryn M. Kitrinos1, Anuj Gaggar1, William E. Delaney1, Stephan Boehm2, Thomas Berg2
1Gilead Sciences Inc., 2University Hospital Leipzig

1595 Longitudinal analysis of complicated multiple hepatitis B virus (HBV) S-gene mutations in a patient with HBsAg-negative HBV-related hepatocellular carcinama
Yan Liu1, Jianhong Chen1, Jun Zhao1, Zhihui Xu1, Xiaodong Li1, Jin Li1, Juqiang Han2, Dongping Xu1
1Beijing 302 Hospital, 2, General Hospital of Beijing Military Region

1596 Prevalence of Hepatitis B virus infection in North Eastern states of India
Premashis Kar, Vijay Karra
Maulana Azad Medical College

1597 Performance of the new cobas® HBV Assay on the cobas® 6800 system in comparison to different TaqMan® assays
Benjamin Maasoumy1, Kevin Luk2, Birgit Bremer1, Patrick Lehmann1, Ed G. Marins2, Veronique Michel-Treil3, Ekaterina Gelman3, Merlin Njoya2, Jesse A. Canchola2, Christian O. Simon4, Heiner Wedemeyer1
1Hannover Medical School, 2Roche Molecular Systems Inc., Roche Diagnostics, 3Covance Central Laboratory Services SA, 4Roche Diagnostics International, Ltd

1598 Seroprevalence and Clinical Features of Hepatitis D Virus (HDV) Infection in a North American Cohort
Norah Terrault1, Marc G. Ghany2, Chaeryon Kang3, Stewart Cooper4, Adrian M. Di Bisceglie5, Michael W. Fried6, Steven H. Belle3, Jay H. Hoofnagle2
1UCSF, 2NIH-NIDDK, 3University of Pittsburgh, 4California Pacific Medical Center, 5St. Louis University, 6University of North Carolina

1599 Comparative Study for Anti-Hepatitis B Surface Antigen Titers Based on Two Measurement Methods: Using Monoclonal Antibodies Isolated from Hepatitis B Vaccinated Japanese Recipients.
Takako Inoue1, Shuko Murakami2, Susumu Tsutsumi2, Kumiko Ohne1, Kazuto Tajiri3, Hiroyuki Kishi4, Shintaro Ogawa2, Noboru Shinkai5, Takaaki Goto1, Yukio Wakimoto1, Yasuhito Tanaka2, 1
1Nagoya City University Hospital, 2Nagoya City University Graduate School of Medical Sciences, 3University of Toyama , 4 Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 5Nagoya City University Graduate School of Medical Sciences

1600 Elevated serum levels of WFA(+)-M2BP predict the development of hepatocellular carcinoma in hepatitis B patients with HBeAg
Kazumi Yamasaki, Shigemune Bekki, Yuki Kugiyama, Shinjiro Uchida, Akira Saeki, Satoru Hashimoto, Shinya Nagaoka, Seigo Abiru, Atsumasa Komori, Hiroshi Yatsuhashi
Nagasaki Medical Center

1601 Identification of a non-invasive model based on serum levels of miR-122 and miR-222 to predict severe fibrosis and cirrhosis in patients with chronic hepatitis B.
Kevin Appourchaux5, 2, Emilie Estrabaud5, 2, Matthieu Resche-Rigon3, 4, Martine Lapalus5, 2, Michelle Martinot-Peignoux5, 2, Nathalie Boyer2, Michel Vidaud6, Pierre Bedossa7, 1, Patrick Marcellin5, 2, Tarik Asselah5, 2
1INSERM, 2Beaujon Hospital, 3Saint-Louis Hospital, 4INSERM UMR1153, 5INSERM UMR1149, 6INSERM UMR745, 7Beaujon Hospital

1602 Interleukin-2 Receptor and Transforming Growth Factor Alpha Independently Predict Significant Fibrosis in Chronic Hepatitis B Patients with Normal or Mildly Elevated Alanine Aminotransferase
Gui-Qiang Wang, Yong-Qiong Deng, Hong Zhao
Peking University First Hospital

1603 Characterization of Nucleic acid testing reaction samples and Occult Hepatitis B infection Among blood donors in three cities of China
Xiaomei Wang, Xiumei Chi, Ruihong Wu, Xiuzhu Gao, Junqi Niu
The First Hospital of Jilin University

1604 Baseline quantitative hepatitis B core antibodies can predict HBV DNA and HBsAg seroclearance in treatment-naïve HBeAg negative chronic hepatitis B patients
Hui-Han Hu1, Jessica Liu1, Chia-Lin Chang1, Chin-Lan Jen1, Mei-Hsuan Lee2, Sheng-Nan Lu3, Li-Yu Wang4, San-Lin You1, Pei-Jer Chen5, 6, Hwai-I Yang1, Chien-Jen Chen1, 7
1Academia Sinica, 2National Yang-Ming University, 3Chang-Gung Memorial Hospital, 4MacKay College of Medicine, 5National Taiwan University Hospital, 6Graduate Institute of Clinical Medicine, 7National Taiwan University

1605 Risk assessment of hepatocellular carcinoma development using transient elastography vs. liver biopsy in chronic hepatitis B patients starting antiviral therapy
Mi Na Kim1, Yeon Seok Seo2, Seung Up Kim3, Sang Gyune Kim4, Soon Ho Um2, Kwang-Hyub Han3, Young Seok Kim4
1CHA Gangnam Medical Center, CHA University, 2Korea University College of Medicine, 3Yonsei University College of Medicine, 4Soonchunhyang University Bucheon Hospital

1606 Evaluation of Chronic Hepatitis B Treatment and Assessment of Chronic Hepatitis B Care at an Asian Community Health Center in New York City, 2012
Christopher Su1, 2, Nicole Bannister3, Vivian Huang3
1Montefiore Medical Center, 2Albert Einstein College of Medicine, 3Charles B. Wang Community Health Center

1607 Biomarkers of Fibrosis in Low Replicative Chronic Hepatitis B Patients
Faisal M. Sanai1, 4, Taha Farah6, Khalid Albeladi6, Faisal Batwa6, Yaser Dahlan6, Mohammed A. Babatin2, Hamad I. Al-ashgar7, Hadeel Al-mana3, Khaled Alsaad8, Khalid A. Alswat1, Abdulrahman A. Aljumah4, Ibrahim H. Altraif4, Khalid I. Bzeizi5
1Liver Disease Research Center, 2King Fahad General Hospital, 3King Faisal Specialist Hospital & Research Center, 4King Abdulaziz Medical City, 5Riyadh Military Hospital, 6King Abdulaziz Medical City, 7King Faisal Specialist Hospital & Research Center, 8King Abdulaziz Medical City

1608 Barriers to obtaining appropriate Hepatitis B care among US Veterans
Tatyana Kushner, David E. Kaplan, Marina Serper
Hospital of the University of Pennsylvania

1609 The Usefulness of CLIF-SOFA Score for Diagnosis and Evaluating the Patients with HBV-related Acute-on-Chronic Liver Failure
Zhihong Wan, Chen Li, Shaoli You, HongLing Liu, ShaoJie Xin, Bing Zhu
302 hospital of PLA

1610 Anti-platelet therapy reduces the incidence of hepatocellular carcinoma in patients with chronic hepatitis B
Minjong Lee2, Jeong-Hoon Lee2, Sohee Oh1, Young Chang2, Joon Yeul Nam2, Young Youn Cho2, Jeong-Ju Yoo2, Yuri Cho2, Donghyeon Lee2, Eun Ju Cho2, Su Jong Yu2, Yoon Jun Kim2, Jung-Hwan Yoon2
1Seoul Metropolitan Government Seoul National University Boramae Medical Center, 2Seoul National University College of Medicine

1611 Evaluation of Serum Cell Death Biomarker for Prediction of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Virus Infection
ZhuJun Cao, Hui Wang, Xiaogang Xiang, FengDI Li, KeHui Liu, Weiliang Tang, Yuhan Liu, Lanyi Lin, Qing Guo, Qing Xie
School of Medicine at Shanghai Jiao Tong University

1612 Statin and the risk of hepatocellular carcinoma and death in a hospital-based hepatitis B-infected population: a propensity-score landmark analysis
John C Hsiang, Grace LH Wong, Vincent W. Wong, Henry Lik-Yuen Chan
Chinese University of Hong Kong

1613 Influence of the ethnic status in chronic hepatitis B patients: comparing the Netherlands, Belgium and Turkey.
Özgür M. Koc1, Sarah Konsten1, Geraldine Jansen1, Geert Robaeys2, 3, Beytullah Yildirim4, Dirk Posthouwer5, Ger H. Koek6
1University Maastricht, 2East Limburg Hospital, 3Limburg Clinical Research Program , 4Ondokuz Mayis University, School of Medicine, 5Maastricht University Medical Centre, 6Maastricht University Medical Centre

1614 High-throughput and ultrasensitive assay for the quantification of HBV precore and basal core promoter mutants and their clinical significance
Motokazu Mukaide, Kazumoto Murata, Masaya Sugiyama, Masashi Mizokami
National Center for Global Health and Medicine

1615 Changes of Hepatitis B surface antigen after allogenic hematopoietic stem cell transplantation
Do Seon Song, JinMo Yang, U Im Chang, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
College of Medicine, The Catholic University of Korea

1616 Clinical scoring system for diagnosis of immune tolerant and reactive phases in chronic hepatitis B virus infection
Qing-Lei Zeng, Yan-Ling Fu, Jun Lv, Zu-Jiang Yu
Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University

1617 Postpartum hepatic flare after telbivudine withdrawal in pregnant women with chronic hepatitis B
Jinfeng Liu2, Jing Wang1, Dongfang Jin3, Yingli He2, Li Jin1, Taotao Yan1, Furong Cao1, Yuan Yang2, Shulin Zhang2, Yingren Zhao2, Tianyan Chen2
1Xi'an Jiaotong University, 2The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China, 3Shaanxi Kangfu Hospital

1618 Performance Assessment of Common Anti-hepatitis B Core Antigen Assays in Japan for Prevention of HBV Reactivation.
Takako Inoue1, Tomoya Iwase1, Satomi Kani1, Kumiko Ohne1, Takaaki Goto1, Yukio Wakimoto1, Yasuhito Tanaka2, 1
1Nagoya City University Hospital, 2Nagoya City University Graduate School of Medical Sciences

1619 Does Cesarean section and formula feeding reduce vertical transmission in chronic hepatitis B pregnant mothers?
Rasham Mittal, Amandeep K. Sahota
Kaiser Permanente Los Angeles Medical Center

1620 Hepcidin: A new clinical factor in the patients with HBV-related chronic liver diseases
Jingyun Wang1, Jing Sun1, Xiaomei Wang1, Ruihong Wu1, Hongqin Xu1, Xiuting He1, Lishan Su2, Junqi Niu1, Yanhang Gao3
1The First Hospital of Jilin University, 2University of North Carolina, 3National Institutes of Health NIH/NIAAA

1621 Conconrdance between transient elastography and liver biopsy in patients with chronic hepatitis B e negative
Nawal Guessab1, Nawel Afredj1, Rafik Kerbouche1, Ibtissem Ouled Cheikh1, Sonia Ait Younes2, Samir Gourari3, Yazid Chikhi4, Salima Cheraitia4, Mohamed Merniz5, François Montestruc6, Salah Sahraoui6, Saadi Berkane7, Nabil Debzi1
1Algiers university, 2Algiers university, 3Algiers university, 4Algiers university, 5Boudiaf Hospital, 6Clinica group, 7Algiers university

1622 Evaluation of HBV infection status in spouses of HBsAg-positive individuals
Ebru Dik, Selma Tosun, Seher A. Coskuner, Alpay Ari, Meltem Avci
Bozyaka Education and Research Hospital

1623 Is booster beneficial after universal HBV vaccination?
Selma Tosun1, Erhun Kasirga2
1Bozyaka Education and Research Hospital, 2Celal Bayar University The Faculty of Medicine

1624 Assessment Of Treatment Response By Elastography During The Tenofovir Treatment In Nucleos(t)ide-Naïve Chronic Hepatitis B Patients
Taeheon Lee, Byung Ik Kim, Yong Kyun Cho, Woo Kyu Jeon, Hong Joo Kim
Kangbuk Samsung Hospital

1625 Inadequate Treatment of Chronic Hepatitis B in Pregnant Women at High Risk for Vertical Transmission
Diana Y. Wu1, 2, Muhammad I. Shafi3, 2, Mohammed M. Aboelsoud3, 2, Colin Woodard4, 2
1Women and Infants Hospital, 2Alpert Medical School, 3Memorial Hospital, 4Kent Hospital

Hepatitis B: Virology, Immunology, and Pathogenesis

1626 NK cell function is restored with sequential NUC therapy and correlates with treatment response in Chronic Hepatitis B
Upkar S. Gill1, Dimitra Peppa2, Lorenzo Micco2, Harsimran D. Singh2, Ivana Carey3, Graham R. Foster1, Mala K. Maini2, Patrick T. Kennedy1
1Blizard Institute, Barts and The London, School of Medicine & Dentistry, QMUL, 2UCL, 3Kings College London

1627 Analysis of the effect on HBV life cycle by HBV genome editing using two different CRISPR/Cas9 systems.
Hiromi Abe, Keiichi Masaki, Tetsushi Sakuma, Masataka Tsuge, Nobuhiko Hiraga, Michio Imamura, C. Nelson Hayes, Hiroshi Aikata, Takashi Yamamoto, Kazuaki Chayama
Hiroshima University

1628 Inhibition of epigenetic regulators affects hepatitis B virus replication and hepatitis B surface antigen production in human hepatocytes.
Shingo Nakamoto, Tatsuo Kanda, Shuang Wu, Yuki Haga, Reina Sasaki, Masato Nakamura, Hiroshi Shirasawa, Osamu Yokosuka
Graduate School of Medicine, Chiba University

1629 CRISPR/Cas9 "double"-nickase mediated inactivation of hepatitis B virus replication
Madina Karimova2, Niklas Beschorner2, Werner Dammermann1, Jan Chemnitz2, Daniela S. Indenbirken2, Adam Grundhoff2, 3, Stefan Lueth1, Frank Buchholz4, Schulze zur Wiesch Julian1, 3, Joachim Hauber2, 3
1University Medical Center Hamburg-Eppendorf, 2Heinrich Pette Institute – Leibniz Institute for Experimental Virology, 3German Center for Infection Research (DZIF), partner site Hamburg, 4University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden

1630 GORASP2 regulates HCV and HBV through RNA and/or DNA replication and virion trafficking
Dachuan Cai1, 2, Jian Hong1, Xiao Liu1, Sae Hwan Lee1, Dahlene Fusco1, Esperance A. Schaefer1, Cynthia Brisac1, Anna Lidofsky1, Wenyu Lin1, Raymond T. Chung1
1Massachusetts General Hospital, Harvard Medical School, 2The second affiliated hospital of Chongqing medical university

1631 Genetic Variation in Vitamin D Pathway CYP2R1 gene predict sustained HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon: Multicenter study
Kessarin Thanapirom1, Sirinporn Suksawatamnuay1, Kittiyod Poovorawan2, Wattana Sukeepaisarnjaroen14, Tawesak Tanwandee3, Satawat Thongsawat4, Teerha Piratvisuth5, Rattana Boonsirichan6, Chalermrat Bunchorntavakul7, Chaowalit Pattanasirigool8, Bubpha Pornthisarn9, Supot Tantipanichtheerakul10, Ekawee Sripariwuth12, Woramon Jeamsripong13, Theeranun Sanpajit11, Piyawat Komolmit1
1Chulalongkorn University, 2Mahidol University, 3Siriraj hospital, 4Chiang Mai University, 5Prince of Songkla University, 6Vajira Hospital, 7Rajavithi Hospital, 8Police General hospital, 9Thammasat University Hospital, 10Bhumibol Adulyadej Hospital, 11Phramongkutklao Hospital, 12Naresuan University, 13Buddhachinaraj Hospital, 14Khon Kaen University

1632 Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese
Nao Nishida1, 2, Jun Ohashi2, Masaya Sugiyama1, Takayo Tsuchiura1, Ken Yamamoto3, Keisuke Hino4, Masao Honda5, Shuichi Kaneko5, Hiroshi Yatsuhashi6, Kazuhiko Koike2, Osamu Yokosuka7, Eiji Tanaka8, Akinobu Taketomi9, Masayuki Kurosaki10, Namiki Izumi10, Naoya Sakamoto11, Yuichiro Eguchi12, Takehiko Sasazuki13, Katsushi Tokunaga2, Masashi Mizokami1, Tatsuya Kanto1
1NCGM, 2The University of Tokyo, 3Kurume University School of Medicine, 4Kawasaki Medical School, 5Kanazawa University Graduate School of Medicine, 6National Nagasaki Medical Center, 7Chiba University, 8Shinshu University School of Medicine, 9Hokkaido University, 10Musashino Red Cross Hospital, 11Hokkaido University Graduate School of Medicine, 12Saga Medical School, 13Kyushu University

1633 The Combination of KIR and HLA-C Is Associated with Response to Peginterferon and Adefovir Combination Therapy in Chronic Hepatitis B Patients.
Femke Stelma1, 2, Louis Jansen1, 2, Marjan J. Sinnige2, Karel A. van Dort2, Bart Takkenberg1, Ester M. van Leeuwen2, Neeltje A. Kootstra2, Hendrik W. Reesink1
1Academic Medical Center, 2Academic Medical Center

1634 NFATc3 exerts anti-viral and anti-tumor dual function in hepatitis B virus-related hepatocellular carcinoma by activating interferon pathway
Xiangmei Chen, Jin Cheng, Zhenzhen Zeng, Fengmin Lu
Peking Univercity Health Science Center

1635 Generation of human peripheral blood mononuclear cells-engrafted mice for the study of immunological response against hepatitis B virus
Satoshi Aono1, Tomohide Tatsumi1, Seiichi Tawara1, Yoshiki Onishi1, Akira Nishio1, Shigeki Suemura1, Hayato Hikita1, Ryotaro Sakamori1, Naoki Hiramatsu1, Hiroshi Suemizu2, Takeshi Takahashi2, Tetsuo Takehara1
1Osaka University, 2Central Institute for Experimental Animals

1636 NK cells play important roles in the pathogenesis of HBV infection via alternation of NKp46high NKG2Ahigh subset
Teppei Yoshioka, Yoshinobu Yokoyama, Akira Nishio, Yoshiki Onishi, Kaori Mukai, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Naoki Hiramatsu, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
Osaka university graduate school of medicine

1637 Unique Liver Transcriptomic Profiles in chronic HBV: Intrinsic Intrahepatic Functional Clusters discriminate Distinct Clinical Phases
Jun Hou1, Willem Pieter Brouwer1, Harry L. Janssen2, Thomas Vanwolleghem1, Pim French1, Andre Boonstra1
1Erasmus MC, 2 Toronto Western and General Hospital, University Health Network

1638 The HLA-DPA1 rs3077 TT polymorphism is associated with clearance of hepatitis B virus (HBV) infections in Caucasians
Eleni Koukoulioti, Janett Fischer, Stephan Boehm, Thomas Berg, Florian van Bömmel
University Hospital of Leipzig

1639 Proline142 deletion in the Hepatitis B surface antigen (HBsAg) critically affects virus secretion and results in HBsAg retention in endoplasmic reticulum.
Jaw-Ching Wu1, 2, Ruei-Dun Teng1, Yung-Sheng Chang1, Yu-Wei Chiou2, Chien-Wei Su3
1National Yang-Ming University, 2Taipei Veterans General Hospital, 3Taipei Veterans General Hospital

1640 Endogenous Antigen Presentation by Hepatocytes Plays an Essential Role in the Induction of HBV-specific CD8+ T Cell Responses
Masanori Isogawa1, Yasuhiro Murata2, Keigo Kawashima1, Yasuhito Tanaka1
1Nagoya City University Graduate School of Medical Sciences, 2Mie University Hospital

1641 Initial sites of hepadnavirus-host genome integration after de novo infection of HepaRG cells and woodchuck livers
Ranjit Chauhan, Norma D. Churchill, Thomas I. Michalak
Memorial University

1642 An impact of cellular core-fucosylation in hepatitis B virus infection into hepatoma cell lines
Eiji Miyoshi2, Shinji Takamatsu1, Mayuka Shimomura1, Yoshihiro Kamada1, 3, Haruka Maeda1, Tomoaki Subajima2, Hayato Hikita3, Iijima Mayumi4, Yuta Okamato5, Ryo Misaki5, Kazuhito Fujiyama5, Tetsuo Takehara3, Keiji Ueda6, Shunichi Kuroda4
1Osaka University Graduate School of Medicine, 2Osaka University Graduated School of Medicine, 3Osaka University Graduated School of Medicine, 4Graduate School of Bioagricultural Sciences, Nagoya University, 5International Center for Biotechnology, Osaka University, 6Osaka University Graduated School of Medicine

1643 Indoleamine-2, 3-dioxygenase as the intrinsic anti-HBV effector that leads to durable immune responses in patients with acute hepatitis B: A comparative analysis with the sequence in hepatic flare.
Sachiyo Yoshio1, Masaya Sugiyama1, Hirotaka Shoji1, Yohei Mano1, Yoshihiko Aoki1, Toru Okamoto2, Yoshiharu Matsuura2, Masashi Mizokami1, Tatsuya Kanto1
1National Center for global health and medicine , 2Research Institute for Microbial Diseases, Osaka University

1644 The mechanism of interferon stimulated gene MX1 regulation of HBV and HCV
Wenyu Lin1, Dachuan Cai1, 2, Jian Hong1, Xiao Liu1, Hong Zhao1, Chuanlong Zhu1, Dahlene Fusco1, Esperance A. Schaefer1, Cynthia Brisac1, Sae Hwan Lee1, Anna Lidofsky1, Raymond T. Chung1
1Massachusetts General Hospital, Harvard Medical School, 2The second affiliated hospital of Chongqing medical university

1645 Difference of intracellular responses by HBV genotype A and C infection in humanized mouse model
Masataka Tsuge1, Nobuhiko Hiraga1, Hiromi Abe1, Daiki Miki2, Michio Imamura1, Hidenori Ochi1, C. Nelson Hayes1, Kazuaki Chayama1
1Hiroshima university, 2Institute of Physical and Chemical Research (RIKEN)

1646 Massive Intrahepatic Production of Germ-line Antibodies with High Affinity Against HBcAg Is Specifically Associated with Fulminant But Not with Classic Acute Hepatitis B: New Insights Into Pathogenesis
Zhaochun Chen1, Huaying Zhao2, Peter Schuck2, Ronald E. Engle1, Fausto Zamboni3, Giacomo Diaz4, David E. Kleiner5, Robert H. Purcell1, Patrizia Farci1
1National Inst of Health, 2National Institutes of Health, 3Brotzu Hospital, 4University of Cagliari, 5National Cancer Institute

1647 The expansion of CD11b-CD27- NK-cell subset contributes to HBV persistence via TGF-ß1
Qiongfang Zhang1, 2, Wenwei Yin1, 2, Jian-ying Shao1, 2, Qian Liu1, 2, Peng Hu1, 2, Huaidong Hu1, 2, Hong Ren1, 2, Dazhi Zhang1, 2
1Chongqing Medical University, 2The Second Affiliated Hospital of Chongqing Medical University

1648 Comprehensive analysis of the Rab family to screen membrane traffic pathways utilized by hepatitis B virus
Jun Inoue, Yasuteru Kondo, Teruyuki Umetsu, Takuya Nakamura, Takayuki Kogure, Yu Nakagome , Yuta Wakui, Tatsuki Morosawa, Yasuyuki Fujisaka, Satoshi Takai, Tooru Shimosegawa
Tohoku University Graduate School of Medicine

1649 Genome-wide scan of miRNA polymorphisms revealed a suggestive association of miR-3143 with chronic hepatitis B virus infection
Daiki Miki1, 2, Hidenori Ochi1, 2, C. Nelson Hayes1, 2, Hiromi Abe1, 2, Sakura Akamatsu1, 2, Atsushi Ono1, 2, Takashi Nakahara1, 2, Yizhou Zhang1, 2, Keiichi Masaki1, 2, Hatsue Fujino1, 2, Eisuke Miyaki1, 2, Hiromi Kan1, 2, Takuro Uchida1, 2, Nobuhiko Hiraga1, 2, Masataka Tsuge1, 2, Tomokazu Kawaoka1, 2, Michio Imamura1, 2, Yoshiiku Kawakami1, 2, Hiroshi Aikata1, 2, Kazuaki Chayama1, 2
1RIKEN Center for Integrative Medical Sciences, 2Hiroshima University Hostital

1650 Hepatitis delta virus-induced T-cell recruiting chemokines contribute to inflammatory liver injury in chronic hepatitis delta
Eui-Cheol Shin1, 2, Nydiaris Hernandez-Santos1, Christopher Koh1, Mary DeMino1, Theo Heller1, Barbara Rehermann1
1National Institutes of Health, 2Korea Advanced Institute of Science and Technology

1651 Deletion of APOBEC3B is Associated With Hepatitis B eAg Status in Patients with Chronic HBV Infection
Alex J. Thompson1, Ondrej Podlaha2, Zhaoshi Jiang2, Xin Guo2, Luting Zhuo2, Dongliang Ge2, Anuj Gaggar2, Mani Subramanian2, David B. Goldstein3, Henry Lik-Yuen Chan4, Edward J. Gane5, Harry L. Janssen6
1St. Vincent’s Hospital and the University of Melbourne, 2Gilead Sciences, Inc., 3Institute for Genomic Medicine, Columbia University, 4The Chinese University of Hong Kong, 5Auckland City Hospital, 6University of Toronto, Toronto General Hospital

1652 Effect of a novel synthetic FXR agonist EYP001 on hepatitis B virus replication in HepaRG cell line and primary human hepatocytes
Pauline Radreau2, Marine Porcherot1, Jacky Vonderscher2, Vincent Lotteau1, Patrice André1
1INSERM, 2EnyoPharma

1653 HBcrAg during nucleos(t)ide analog therapy are related to intra-hepatic HBV replication and development of hepatocellular carcinoma
Masao Honda, Takayoshi Shirasaki, Takeshi Terashima, Kazunori Kawaguchi, Mikiko Nakamura, Naoki Oishi, Tetsuro Shimakami, Hikari Okada, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
Kanazawa University Graduate School of Medical Science

1654 Free episomal and integrated HBV DNA In HBsAg-negative patients with intrahepatic cholangiocarcinoma
Teresa Pollicino1, Cristina Musolino2, Gianluca Tripodi2, Marika Lanza2, Giuseppina Raffa2, Carlo Saitta2, Salvatore Benfatto1, Concetta Beninati1, Giuseppe Navarra3, Pietro Invernizzi4, Domenico Alvaro5, Giovanni Raimondo2
1University of Messina, 2University Hospital of Messina, 3University Hospital of Messina, 4Humanitas Clinical and Research Center, 5University of Rome "Sapienza"

1655 A Novel Entecavir Resistance Mutation RtA186T Causes Viral Breakthrough in Chronic Hepatitis B Patients
Sanae Hayashi1, Shuko Murakami1, Katsumi Omagari1, Takeshi Matsui2, Etsuko Iio1, Masanori Isogawa1, Tsunamasa Watanabe1, Yoshiyasu Karino3, Yuki Takamatsu4, Satoru Kohgo5, Kenji Maeda5, Hiroaki Mitsuya4, 5, Yasuhito Tanaka1
1Nagoya City University Graduate School of Medical Sciences, 2Teine Keijinkai Hospital, 3Sapporo Kosei General Hospital, 4National Institutes of Health, 5National Center for Global Health and Medicine

1656 Hepatitis B Virus Surface Protein-induced hPIAS1 Transcription Requires TAL1, E47, MYOG, NFI, andMAPK Signal Pathways
Hongyan Wang, Di Wu, Xiaofeng Wang, Guang Chen, Yuanya Zhang, Weiming Yan, Meifang Han, Qin Ning
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

1657 The activating receptor NKP46 is essential for the development of chronic hepatitis B
Wanyu Li, Xiuzhu Gao, Ruqi Mei, Jinglan Jin, Junqi Niu
the first hospital of jilin university

1658 Impact of toll-like receptor 4 signaling on liver fibrosis in uPA/SCID mice with human hepatocytes persistently infected with hepatitis B virus
Masaya Sugiyama, Tatsuya Kanto, Masaaki Korenaga, Kazumoto Murata, Naohiko Masaki, Masashi Mizokami
National Center for Global Health and Medicine

1659 Genome wide miRNA: mRNA Integrome Analysis reveals key pathways, biological processes and gene families in Dendritic cells (DCs) that differentiate various stages of HBV Infection
Avishek K. Singh1, Robert Geffers2, Sheetalnath B. Rooge1, Aditi Varshney1, Madavan Vasudevan3, Ankit Bhardwaj1, Manoj Kumar4, Pawan Malhotra5, Sunil K. Mukherjee5, Raj K. Bhatnagar5, Nirupma Trehanpati1, Shiv K. Sarin4
1Institute of Liver and Biliary Sciences, 2Helmholtz Centre for Infection Research , 3Bionivid Technology Pvt Ltd, 4Institute of Liver and Biliary Sciences, 5International Centre for Genetic Engineering and Biotechnology (ICGEB)

1660 Functional restoration of CD56bright NK cells via IL-15 and NKG2D correlates with antiviral treatment efficacy in chronic hepatitis B patients
Tao Chen1, Aichao Shi1, Xiaoping Zhang1, Lin Zhu1, Zeguang Wu1, Weiming Yan1, Xiaojing Wang1, Hong Ma2, Jidong Jia2, Wei Guo1, Qin Ning1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2Beijing Friendship Hospital

1661 Knockdown of NTCP reduces susceptibility to HBV infection in humanized-liver mice.
Tasuku Nakabori, Hayato Hikita, Satoshi Aono, Yoshinobu Yokoyama, Kazuhiro Murai, Takuo Yamai, Yugo Kai, Yuki Makino, Yasutoshi Nozaki, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Osaka University Graduate School of Medicine

1662 The Association of vitamin D metabolic pathway related genes polymorphisms with virologic response in HBeAg-negative patients treated with pegylated interferon: Multicenter study
Kessarin Thanapirom1, Sirinporn Suksawatamnuay1, Wattana Sukeepaisarnjaroen2, Tawesak Tanwandee3, Satawat Thongsawat4, Teerha Piratvisuth5, Rattana Boonsirichan6, Chalermrat Bunchorntavakul7, Chaowalit Pattanasirigool8, Bubpha Pornthisarn9, Supot Tantipanichtheerakul10, Ekawee Sripariwuth11, Woramon Jeamsripong12, Theeranun Sanpajit13, Piyawat Komolmit1
1Chulalongkorn University, 2Khon Kaen University, 3Mahidol University, 4Chiang Mai University, 5Prince of Songkla University, 6Vajira Hospital, 7Rajavithi Hospital, 8Police General hospital, 9Thammasat University Hospital, 10Bhumibol Adulyadej Hospital, 11Naresuan University, 12Buddhachinaraj Hospital, 13Phramongkutklao Hospital

1663 Defective humoral immunity in Hepatitis B virus (HBV) infected mother leads to Vertical Transmission of HBV to newborns
Ashish Vyas1, Sharda Patra2, Paul David1, Guresh Kumar1, Shiv K. Sarin1, Nirupma Trehanpati1
1Institute of Liver and Biliary Sciences, 2Ladhy Hardinge Medical College

1664 Humic matter inhibits HBV-induced autophagosome formation and induces apoptosis in HBV-transfected HepG2 Cells
Kishor Pant, Parul Gupta, Ajay K. Yadav, Senthil K. Venugopal
South Asian University

1665 Large Hepatitis Delta Antigen specifically activates Twist and Epithelial-Mesenchymal through its binding with Smad3
Jaw-Ching Wu1, 2
1National Yang-Ming University, 2Taipei Veterans General Hospital

1666 Presence of naïve-like CD8+ T cells specific for subdominant hepatitis B virus epitopes in chronically infected patients
Anita Schuch1, 2, Muthamia Kiraithe1, 2, Julia Lang1, Christoph Neumann-Haefelin1, Robert Thimme1
1University Hospital Freiburg, 2University of Freiburg

1667 Precore and Basal Core Promoter mutations in HBeAg negative chronic hepatitis B virus infection in Cape Town, South Africa
Mark W. Sonderup1, Heidi Smuts2, Ruud A. Roos3, 1, Helen Wainwright4, Neliswa A. Gogela1, Mashiko Setshedi1, Henry N. Hairwadzi1, C. W. Spearman1
1University of Cape Town, 2Division of Medical Virology, University of Cape Town and NHLS, 3Vrije Universiteit, 4Department of Anatomical Pathology, University of Cape Town

1668 Differential Serum Cytokine Profiles in Patients with Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Non-Viral Non-Autoimmune Liver Disease, with or without Hepatocellular Carcinoma (HCC)
Vincent L. Chen2, Philip Vutien3, 5, Biao Li4, Ondrej Podlaha4, Ellen T. Chang5, Zhaoshi Jiang4, Dongliang Ge4, Anuj Gaggar4, Mindie H. Nguyen1
1Stanford University Medical Center, 2Stanford University Medical Center, 3Rush University Medical Center, 4Gilead Sciences, Inc., 5Stanford University School of Medicine

1669 Possible involvement of hepatic steatosis in the elevation of aminotransferases in hepatitis B virus-infected patients who are HBeAg-negative and have low DNA levels
Hirayuki Enomoto, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Kazunori Yoh, Ryo Takata, Chikage Nakano, Kunihiro Hasegawa, Kyohei Kishino, Yoshihiro Shimono, Akio Ishii, Tomoyuki Takashima, Takashi Nishimura, Hiroki Nishikawa, Yoshinori Iwata, Hiroko Iijima, Shuhei Nishiguchi
Hyogo College of Medicine

1670 Human cytotoxic T lymphocyte-mediated acute liver failure and rescue by immunoglobulin in human hepatocyte transplanted TK-NOG mice
Takuro Uchida1, Nobuhiko Hiraga1, Michio Imamura1, Hiromi Kan1, Eisuke Miyaki1, Masataka Tsuge1, Hiromi Abe1, Nelson Hayes1, Hiroshi Aikata1, Yuji Ishida2, Chise Tateno2, Kazuaki Chayama1
1Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University, 2PhoenixBio Co., Ltd.

1671 Geranylgeranylacetone exerts anti-hepatitis B virus activity by suppressing Enhancer-1 activity in human hepatoma cells.
Masafumi Haraguchi1, Satoshi Miuma1, Yuko Akazawa1, Hidetaka Shibata1, Takuya Honda1, Hisamitsu Miyaaki1, Naota Taura1, Tatsuki Ichikawa2, Kazuhiko Nakao1
1Nagasaki University Graduate School of Biochemical Sciences, 2Nagasaki Harbor Medical Center City Hospital

1672 Dynamic Analysis Of Cellular Factors Modulated By Hepatitis B Virus Protein Expression And Replication
Kenichi Morikawa1, Tomoe Shimazaki1, Takaaki Izumi1, Machiko Umemura1, Masato Nakai1, Goki Suda1, Darius Moradpour2, Naoya Sakamoto1
1Hokkaido University, 2University of Lausanne

1673 IFN-?3 induction by nucleotide, not nucleoside, analogs and its clinical significance in HBV patients
Kazumoto Murata1, Akihiro Matsumoto2, Taisuke Inoue3, Minoru Sakamoto3, Masaya Sugiyama1, Nobuyuki Enomoto3, Eiji Tanaka2, Masashi Mizokami1
1National Center for Global Health and Medicine, 2Shinshu University School of Medicine, 3University of Yamanashi

1674 Long-term follow-up study of hepatitis delta virus quasispecies complexity
Maria Homs1, 2, Maria Buti1, 3, Alicia Ruiz4, Pilar Reimundo4, Josep Gregori5, Maria Blasi1, 2, Rosario Casillas5, David Tabernero1, 2, Marta Vila5, Leonardo Nieto2, Josep Quer1, 5, Mar Riveiro-Barciela3, Rafael Esteban1, 3, Francisco Rodriguez-Frias1, 2
1CIBERehd, 2Hospital Vall d'Hebron, 3Hospital Vall d'Hebron, 4Hospital Vall d'Hebron, 5Research Institute of Vall d'Hebron

1675 Comparison of detection rate and mutational pattern of drug-resistant mutations between a large cohort of genotype B and genotype C hepatitis B virus-infected patients in North China
Xiaodong Li, Yan Liu, Shaoli You, Jinhua Hu, Jun Zhao, ShaoJie Xin, Dongping Xu
Beijing 302 Hospital

1676 Noninvasive markers of liver fibrosis remain stable in the majority of hepatitis B virus and human immunodeficiency virus co-infected patients undergoing tenofovir-containing antiretroviral therapy
Anders Boyd1, Karine Lacombe1, 2, Pierre-Marie Girard1, 2, Caroline Lascoux-combe3, Patrick Miailhes4, Hayette Rougier2, Lawrence Serfaty 2
1Inserm UMR_S1136, 2Hôpital Saint-Antoine, 3Hôpital Saint-Louis, 4Hôpital Croix-Rousse

1677 Factors associated with decreases in estimated glomular filtration rates for patients co-infected with hepatitis B virus and human immunodeficiency virus undergoing tenofovir-containing antiretroviral therapy
Anders Boyd1, Karine Lacombe2, 1, Patrick Miailhes3, Caroline Lascoux-combe4, Hayette Rougier2, Julie Bottero2, 1, Pierre-Marie Girard2, 1
1Inserm UMR_S1136, 2Hôpital Saint-Antoine, 3Hospices Civils de Lyon, 4Hôpital Saint-Louis

1678 No Detectable Resistance to Tenofovir Disoproxil Fumarate (TDF) when Given Alone or in Combination with Emtricitabine (FTC) in Chronic Hepatitis B (CHB) Patients with Documented Resistance to Lamivudine (LAM): Final 5 Year Results
Thomas Berg2, Edward J. Gane3, Maciej S. Jablkowski4, Petr Urbanek5, Amoreena C. Corsa1, Yang Liu1, Kyungpil Kim1, John F. Flaherty1, Cihan Yurdaydin6, Scott Fung7, Kathryn M. Kitrinos1
1Gilead Sciences, 2University Hospital Leipzig, 3New Zealand Liver Transplant Unit, 4Medical University of Lodz, 5Central Military Hospital Prague, 6Ankara University Medical School, 7Toronto General Hospital

1679 Novel robust in vitro hepatitis B virus infection system using fresh primary human hepatocytes isolated from chimeric mice with humanized livers
Yuji Ishida1, 2, Chihiro Yamasaki1, Ami Yanagi1, Yasumi Yoshizane1, Kazuyuki Fujikawa4, Koichi Watashi3, Hiromi Abe4, 5, Takaji Wakita3, Nelson Hayes4, 2, Kazuaki Chayama4, 2, Chise Tateno1, 2
1PhoenixBio Co., Ltd., 2HIroshima University, 3National Institute of Infectious Diseases, 4Hiroshima University, 5RIKEN Center for Integrative Medical Science

1680 Modeling Hepatits B Virus infection in stem cell derived hepatocytes reveals role of perturbations in NTCP genotype and expression in HBV permissiveness
Angela Frankel, Robert E. Schwartz
Weill Cornell Medical College

1681 Genetic association study failed to confirm an association between the NTCP S267F mutation and persistence of hepatitis B virus or development of hepatocellular carcinoma in the Japanese population
Daiki Miki1, 2, Hidenori Ochi1, 2, C. Nelson Hayes1, 2, Hiromi Abe1, 2, Sakura Akamatsu1, 2, Atsushi Ono1, 2, Takashi Nakahara1, 2, Yizhou Zhang1, 2, Keiichi Masaki1, 2, Hatsue Fujino1, 2, Eisuke Miyaki1, 2, Hiromi Kan1, 2, Takuro Uchida1, 2, Nobuhiko Hiraga1, 2, Masataka Tsuge1, 2, Tomokazu Kawaoka1, 2, Michio Imamura1, 2, Yoshiiku Kawakami1, 2, Hiroshi Aikata1, 2, Kazuaki Chayama1, 2
1RIKEN Center for Integrative Medical Sciences, 2Hiroshima University Hospital

1682 Serial Changes of Th1 and Th17 Cytokines and a SNP in HLA class II DPB1 Gene Associated with Hepatitis B Virus Reactivation in Patients Treated with Immunomodulatory Agents
Hidetaka Matsuda, Tomoyuki Nemoto, Yoshihiko Ozaki, Tatsushi Naito, Masahiro Ohtani, Katsushi Hiramatsu, Hiroyuki Suto, Yasunari Nakamoto
University of Fukui

1683 Downregulation of TLR2 on CD14+monocytes and upregulation of PD-1 on CD8+T cells correlate with virological breakthrough in entecavir suppressed CHB patients with sequential Peginterferon alfa treatment
Di Wu, Weiming Yan, Guang Chen, Meifang Han, Qin Ning
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

1684 IFN-a-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection
Yong Li1, Yuchen Xia3, Meifang Han2, Guang Chen2, Wolfgang E. Thasler4, Xiaoping Luo1, Ulrike Protzer3, Qin Ning2
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 3TechnischeUniversität München–Helmholtz Zentrum München, 4Ludwig Maximilians University

1685 Hepatitis B virus down regulates the expression levels of Vitamin D receptor in hepatocellular carcinoma (HepG2) transfected cells thereby preventing the inhibition of viral transcription and production by Vitamin D
Neta Gotlieb1, Irina Tachlytski1, Maya Sultan1, Michal Safran1, Ziv Ben Ari1, 2
1Sheba Medical Center, 2Tel Aviv University

1686 The role of HBV quasispecies evolution in HBeAg-negative reactivation
Guan Huei Lee1, 2, Hui Heng Chong2, Seng Gee Lim2
1National University Health System, 2Yong Loo Lin School of Medicine

Pediatric Liver Disease

1687 Hepatic macrophage IL-1 beta expression and bile and sterol transporter suppression precede cholestasis in a parenteral nutrition mouse model
Karim C. El Kasmi, Aimee Anderson, Michael W. Devereaux, Ronald J. Sokol
UC Denver

1688 Molecular mechanism of IL-1 beta mediated transcriptional suppression of the sterol transporter Abcg5/8 in a parenteral nutrition mouse model
Karim C. El Kasmi, Aimee Anderson, Padade M. Vue, Michael W. Devereaux, Natarajan Balasubramaniyan, Frederick J. Suchy, Ronald J. Sokol
UC Denver

1689 Enteral Obeticholic Acid Promotes Intestinal Growth in Total Parenteral Nutrition Fed Neonatal Pigs
Yanjun Jiang1, Zhengfeng Fang2, Barbara Stoll1, Gregory J. Guthrie1, Jens Holst3, Bolette Hartmann3, Douglas Burrin1, 4
1Department Pediatrics, Baylor College of Medicine, 2Sichuan Agricultural University , 3University of Copenhagen, 4Department Pediatrics, Baylor College of Medicine

1690 Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2
Kazuo Imagawa1, 2, Kazuo Takayama2, 3, Shigemi Isoyama1, Ken Tanikawa4, Masato Shinkai5, Masayoshi Kage4, Kenji Kawabata6, 7, Ryo Sumazaki1, Hiroyuki Mizuguchi2, 3
1Faculty of Medicine, University of Tsukuba, 2National Institute of Biomedical Innovation, 3Graduate School of Pharmaceutical Sciences, Osaka University, 4Kurume University Hospital, 5Kanagawa Children's Medical Center, 6National Institute of Biomedical Innovation, 7Graduate School of Pharmaceutical Sciences

1691 King’s-Variceal Prediction Score (K-VaPS); a non invasive assessment tool of severe portal hypertension in cirrhotic children
Peter Witters, Dominic A. Hughes, Palaniswamy Karthikeyan, Alastair j. Baker, Mark Davenport, Anil Dhawan, Tassos Grammatikopoulos
King's College Hospital NHS Foundation Trust

1692 The Rotavirus Induced Mouse Model of Biliary Atresia is Associated with Down Regulation of Bile Acid Transporters that are Restored in B cell Deficient Mice
Asokan Rengasamy, Karim C. El Kasmi, Brianna Traxinger, Jonathan Roach, Natarajan Balasubramaniyan, Cara L. Mack
Children's Hospital Colorado, University of Colorado School of Medicine

1693 Exome Sequencing and de novo Mutation Analysis Reveal a Highly Connected Gene Network in Isolated Biliary Atresia
Kathleen M. Loomes5, 1, Ramakrishnan Rajagopalan2, Christopher Grochowski2, Ying Chen3, 4, Melissa Gilbert2, Henry C. Lin5, 1, Marcella Devoto4, 1, Nancy B. Spinner2, 6
1University of Pennsylvania Perelman School of Medicine, 2The Children's Hospital of Philadelphia, 3University of Pennsylvania Perelman School of Medicine, 4The Children's Hospital of Philadelphia, 5The Children's Hospital of Philadelphia, 6University of Pennsylvania Perelman School of Medicine

1694 DXA Bone Density in Alagille Syndrome Correlates with Fracture History and Degree of Cholestasis
Kathleen M. Loomes2, Cathie Spino14, Nathan P. Goodrich1, Thomas N. Hangartner15, Amanda E. Marker15, James E. Heubi16, Binita M. Kamath13, Benjamin Shneider17, Philip Rosenthal3, Paula M. Hertel17, Saul J. Karpen 4, Nanda Kerkar5, 19, Jean P. Molleston6, Karen F. Murray7, Kathleen B. Schwarz8, Jeffrey Teckman18, Yumirle P. Turmelle9, Peter F. Whitington20, Averell H. Sherker10, John C. Magee 11, Ronald J. Sokol12
1Arbor Research Collaborative for Health, 2Children’s Hospital of Philadelphia, 3UCSF-University of California, San Francisco, 4Emory University School of Medicine/Children's Healthcare of Atlanta, 5Children's Hospital of Los Angeles, 6Indiana University School of Medicine/Riley Hospital for Children, 7University of Washington Medical Center, Seattle Children's, 8Johns Hopkins School of Medicine, 9Washington University School of Medicine, 10Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 11University of Michigan Medical School, 12University of Colorado, 13Hospital for Sick Children and University of Toronto, 14University of Michigan, 15Wright State University, 16Cincinnati Children’s Hospital Medical Center, 17Baylor College of Medicine, 18Saint Louis University, Cardinal Glennon Children's Medical Center, 19Mount Sinai, 20Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg Medical School

1695 Expansion of regulatory T cells reduces hepatic lymphocyte responses and hepatobiliary injury in murine sclerosing cholangitis
Amy E. Taylor1, Alexandra Menchise2, Celine S. Lages1, Julia Simmons1, Shiva K. Shanmukhappa3, Wujuan Zhang4, Melissa Oehrle4, Kenneth D. Setchell4, Alexander G. Miethke1
1Cincinnati Children's Hospital Medical Center, 2Children's Hospital of Philadelphia, 3Cincinnati Children's Hospital Medical Center, 4Cincinnati Children's Hospital Medical Center

1696 Diagnostic determination system for high-risk screening for inborn errors of bile acid metabolism: Results during 20 years in East Asia
Nakayuki Naritaka1, Mitsuyoshi Suzuki1, Hajime Takei2, Akihiko Kimura3, Takao Kurosawa4, Takashi Iida5, Hiroshi Nittono2, Toshiaki Shimizu1
1Juntendo University Faculty of Medicine, 2Junshin Clinic bile acid institute, 3Kurume University School of Medicine, 4Faculty of Pharmaceutical Sciencies, Health Services University of Hokkaido, 5Nihon University College of Humanities and Sciences

1697 Role of transient elastography to differentiate children with biliary atresia from other causes of neonatal cholestasis
Bikrant B. Lal, Rajeev Khanna, Vikrant Sood, Dinesh Rawat, Seema Alam
INSTITUTE OF LIVER AND BILIARY SCIENCES

1698 C5aR targets immune and epithelial cell compartments in experimental and human biliary atresia
Priya Ramachandran1, Mukul Vij2, Mohamed Safwan3, Mohamed Rela3, Pranavkumar Shivakumar4
1Kanchi Kamakoti CHILDS Trust Hospital and Medical Research Foundation, 2Global Hospitals, 3Global Hospitals and National Foundation for Liver Research, 4Cincinnati Children's Hospital Medical Center

1699 B cell activation in the rotavirus-induced mouse model of biliary atresia
Brianna Traxinger1, 2, Asokan Rengasamy1, 2, Jonathan Roach1, 2, Cara L. Mack1, 2
1Children's Hospital Colorado, 2University of Colorado School of Medicine

1700 Prediction of nucleotide analogue treatment outcome in pediatric patients by means of evolutionary inference of HBV PreC/C domain
Christophe Rodriguez1, 2, Etienne Audureau3, 4, Melanie Mercier-Darty1, Stephane Chevaliez1, 2, Jean-Michel Pawlotsky1, 2
1Hospital, 2INSERM, 3APHP, 4Univeristy Paris-est Creteil

1701 Quantitative Maternal Hepatitis B Surface Antigen Predicts Maternally Transmitted Hepatitis B Virus Infection
Wan-Hsin Wen1, 2, Chi-Wen Huang3, 4, Wei-Chu Chie4, Chun-Yan Yeung5, Lu-Lu Zhao6, Wen-Terng Lin7, Jia-Feng Wu3, Yen-Hsuan Ni3, Hong-Yuan Hsu3, 8, Mei-Hwei Chang3, Lung-Huang Lin9, 2, Huey-Ling Chen3, 8
1Cardinal Tien Hospital, 2Fu-Jen Catholic University, 3Hospital and College of Medicine, National Taiwan University, 4College of Public Health, National Taiwan University, 5Mackay Memorial Hospital, 6Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 7En Chu Kong Hospital, 8College of Medicine, National Taiwan University, 9Cathay General Hospital

1702 Predictors of poor outcome in pediatric primary sclerosing cholangitis: a multicenter collaboration
Sylvia Doan1, Wael El-Matary3, Raghu Varier4, Anastasia Konidari2, Marcus K. Auth2, M. K. Jensen1, Mark Deneau1
1University of Utah, 2University of Liverpool, 3University of Manitoba, 4NW Pediatric Gastroenterology, LLC

1703 Dissecting cellular entry mechanisms by enveloped and nonenveloped hepatitis E virus
Xin Yin, Zongdi Feng
Research Institute at Nationwide Children's Hospital

1704 Pre-core region mutations analysis helps to delineate immune stage in HBeAg+ children with chronic hepatitis B
Ivana Carey, Sanjay Bansal, Sarah Tizzard, Matthew J. Bruce, Mary Horner, Kosh Agarwal, Diego Vergani, Giorgina Mieli-Vergani
Kings College School of Medicine at King's College Hospital

1705 The Impact of Hepatitis B Vaccine Failure on the Long-Term Natural Course of Chronic Hepatitis B Virus Infection in Children
Chi-San Tai1, Mei-Hwei Chang1, 2, Jia-Feng Wu1, Huey-Ling Chen1, Hong-Yuan Hsu1, Yen-Hsuan Ni1
1National Taiwan University Hospital, 2National Taiwan University Hospital

1706 CD4+ helper T Cell Dysregulation in Children with Hepatitis C Differs from that Observed in Adults
Melissa A. Sheiko1, Lucy Golden-Mason2, Christine Waasdorp Hurtado1, Cara L. Mack1, Silvia Giugliano2, Michael R. Narkewicz1, Hugo R. Rosen2
1University of Colorado Denver, 2University of Colorado Denver School of Medicine

1707 Pharmacokinetics of Once Daily Sofosbuvir or Ledipasvir/Sofosbuvir in HCV-Infected Adolescents
Brian Kirby, Polina German, Bittoo Kanwar, Liyun Ni, Isobel Lakatos, John Ling, Anita Mathias
GIlead Sciences, Inc

1708 HCV infection shifts CD8+ T cell Naïve and Memory Subsets in the Maternal Fetal Interface (MFI)
Melissa A. Sheiko1, Rachel McMahan2, Lucy Golden-Mason2, Christine Waasdorp Hurtado1, Mona Krull3, Silvia Giugliano2, Angela M. Mitchell2, Michael R. Narkewicz1, Hugo R. Rosen2
1University of Colorado Denver School of Medicine, 2University of Colorado Denver School of Medicine, 3DenverHealth Medical Center

1709 The Natural History of Autoimmune Hepatitis and Corresponding Azathioprine Dosing in Children
Melissa A. Sheiko1, Kelley E. Capocelli2, Shikha Sundaram1, Zhaoxing Pan1, Annette McCoy1, Cara L. Mack1
1University of Colorado Denver, 2University of Colorado Denver School of Medicine

1710 Long-term follow up of childhood autoimmune liver disease: the importance of resolving nomenclature
Jeremy K. Rajanayagam1, 3, James W. Ferguson2, Ye H. Oo2, 3, David H. Adams2, 3, Deirdre A. Kelly1, Gideon Hirschfield2, 3
1BIrmingham Children's Hospital, 2Queen Elizabeth Hospital, 3University of Birmingham

1711 Autoimmune Liver disease in Children with Sickle Cell Disease
Suttiruk Jitraruch2, Emer Fitzpatrick2, Maesha Deheragoda2, Giorgina Mieli-Vergani2, Sue Height1, Nedim Hadzic2, Marianne Samyn2
1King's College Hospital, 2Institute of Liver Studies, King's College Hospital

1712 “Hepatic Granulomas: 18 Year Experience of a Tertiary Paediatric Liver Centre in the UK”
Marumbo P. Mtegha, Katie Hunt, Nedim Hadzic, Maesha Deheragoda, Sanjay Bansal
King's College Hospital

1713 Differentiating autoimmune hepatitis from lupus-associated hepatitis: A paradigm shift in approach to elevated liver enzymes
Andreanne Benidir1, Brian M. Feldman3, Anna Goldenberg2, Earl Silverman3, Sindhu Johnson4, Binita M. Kamath1
1The Hospital for Sick Chidlren, 2Research Institute - The Hospital for Sick Children, 3The Hospital for Sick Children, 4Toronto Western Hospital

1714 Screening for Mitochondrial Disease in Pediatric Acute Liver Failure: The Role of Lactate and Pyruvate
Amy G. Feldman1, 5, Ronald J. Sokol1, 5, Regina M. Hardison4, Estella M. Alonso2, 6, Robert H. Squires3, 7, Michael R. Narkewicz1, 5
1Children's Hospital Colorado, 2Ann and Robert H Lurie Children's Hospital of Chicago, 3Children's Hospital of Pittsburgh, 4University of Pittsburgh, 5University of Colorado School of Medicine, 6Northwestern University Feinberg School of Medicine, 7University of Pittsburgh School of Medicine

1715 Nocturnal Hypoxia is associated with Hedgehog Signaling and Severity of Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD)
Shikha Sundaram1, Marzena Swiderska-Syn2, Ronald J. Sokol1, Zhaoxing Pan1, Ann C. Halbower1, Kelley E. Capocelli1, Kristen N. Robbins1, Anna Mae Diehl2
1Children's Hospital Colorado, 2Duke University

1716 Risk Factors Associated with Cystic Fibrosis-associated Liver Disease (CFLD)
Tamir A. Miloh1, 2, Amanda Pope1, John Daye3, Chengcheng Hu3, Peggy Radford1
1Phoenix Children, 2Mayo Clinic, 3University of Arizona

1717 Hepatic Manifestations in Adenosine Deaminase-Deficient Severe Combined Immune Deficiency
Shilpa Lingala1, Elizabeth Garabedian2, Fabio Candotti2, David E. Kleiner4, Kenneth J. Wilkins3, Theo Heller1, Christopher Koh1
1National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 2NIH, 3National Institute of Diabetes, Digestive and Kidney Diseases, 4National Cancer Institute

1718 Autosomal Recessive Polycystic Kidney Disease: Not just a Renal Disease
Sarika Rohatgi1, William E. Sweeney2, Emma Schwasinger2, Nicholas Kampa2, Ellis D. Avner2
1Medical college of Wisconsin, 2Medical college of Wisconsin

1719 Recurrent recessive mutation in DGUOK causes non-cirrhotic intrahepatic portal hypertension in the absence of liver synthetic dysfunction
Silvia Vilarinho4, 1, Sinan Sari2, Guldal Yilmaz3, Buket Dalgic2, Richard P. Lifton1, 5
1Yale University School of Medicine, 2Gazi University - Faculty of Medicine, 3Gazi University - Faculty of Medicine, 4Yale University School of Medicine, 5Yale University School of Medicine

1720 Liver Involvement in Turner’s Syndrome, Is Associated with Extra Hepatic Disease Manifestations.
Ohad Etzion1, Theo Heller1, Ma Ai Thanda Han1, Ruchi Patel1, Christopher Koh1, David E. Kleiner1, 2, Omar Mousa1, Rohit Loomba1, Vladimir Bakalov2, Carolyn Bondy2
1NIH, 2NICHID-NIH

1721 NOTCH2 variants in cholestatic liver disease
Tassos Grammatikopoulos1, S. Strautnieks2, Melissa Sambrotta1, Pierre Foskett2, Maesha Deheragoda2, A. S. Knisely2, Richard J. Thompson1
1King's College London, 2King's College London

1722 Liver Disease in Subjects with N-Glycanse-1 Deficiency
Shilpa Lingala1, David E. Kleiner6, Christina Lam2, Lynne A. Wolfe3, 5, Carlos R. Ferreira2, Donna Krasnewich4, William A. Gahl2, 5, Marc G. Ghany1
1 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 2National Human Genome Research Institute, NIH, 3Undiagnosed Diseases Program, NIH, 4National Institute of General Medical Sciences, NIH, 5National Human Genome Research Institute, NIH, 6National Cancer Institute

1723 Primary immunodeficiencies in cryptogenic acute liver failure in children: a single centre experience
Rajeev Khanna1, Sue Height3, Kimberly Gilmour2, Nedim Hadzic1
1King's College Hospital, 2Great Ormond Street Hospital, 3King's College Hospital

1724 Zinc monotherapy for young pediatric patients with presymptomatic Wilson disease: a two-center experience in Japan
Keisuke Eda1, Itaru Iwama2, Takahito Takeuchi1, Yugo Takaki1, Tatsuki Mizuochi1
1Kurume University School of Medicine, 2Okinawa Chubu Hospital

1725 Congenital Lactic acidemia (CLA), Amino acidemia (AA), Urea cycle defects (UCD) and Organic acidemia (OA) presenting with hepatic dysfunction in sick infants and children: Diagnosis, Management and Outcome in a Pediatric hepatology unit at a specialized liver centre in India.
Seema Alam, Vikrant Sood, Bikrant B. Lal, Dinesh Rawat
ILBS

1726 Bile acid metabolism is altered in adolescents with type 1 diabetes
Zoehrer Evelyn1, Melanie Heckmann1, Elke Fröhlich-Reiterer1, Hildegard Jasser-Nitsche1, Günter Fauler2, Hubert Scharnagl2, Tatjana Stojakovic2, Jörg Jahnel1
1Medical University Graz, 2Medical University Graz

1727 Pre-transplant mortality risk predicts post-transplant survival in pediatric liver transplant recipients
Douglas Mogul, Xun Luo, Allan Massie, Eric Chow, Kathleen B. Schwarz, Andrew M. Cameron, John F. Bridges, Dorry L. Segev
Johns Hopkins

1728 Serum autoantibodies are associated with chronic hepatitis and graft fibrosis after pediatric liver transplantation
Jeremy K. Rajanayagam1, Wolfram Haller1, Dominique Debray2, Henkjan J. Verkade3, Valerie A. McLin4, Helen M. Evans5, Etienne M. Sokal6, Ekkehard Sturm7, Rene Scheenstra3, Annette S. Gouw8, Vladimir Cousin4, Sharat Varma9, Steffen Hartleif7, James Hodson10, Deirdre A. Kelly1
1BIrmingham Children's Hospital, 2Necker Hospital , 3Beatrix Children's Hospital, University Medical Center Groningen, 4University Hospitals Geneva, 5Starship Children's Hospital, 6Université Catholique de Louvain, 7University Children's Hospital, 8University Medical Center Groningen, 9Cliniques universitaires St Luc, 10University Hospitals Birmingham

1729 Racial and ethnic variations in donor type among pediatric liver transplant recipients
Douglas Mogul, Eric Chow, Xun Luo, Allan Massie, Kathleen B. Schwarz, Andrew M. Cameron, John F. Bridges, Dorry L. Segev
Johns Hopkins

1730 Pediatric liver transplant recipients (PLTx) have a different form of pre-diabetes, with decreased ß-cell function rather than insulin resistance
Emily R. Perito1, 2, Robert H. Lustig1, Philip Rosenthal1, 3
1University of California San Francisco, 2University of California San Francisco, 3University of California San Francisco

1731 Regulatory T cells in de novo autoimmune hepatitis (DAIH): friend or foe
Adam Arterbery1, Awo Osafo-Addo1, Maria Ciarleglio2, Yanghong Deng2, Mercedes Martinez3, Steven J. Lobritto3, Yaron Avitzur4, David Hafler5, Markus Kleinewietfeld6, Udeme D. Ekong1
1Yale University School of Medicine, 2Yale School of Public Health, 3Columbia University, 4Hospital for Sick Children, 5Yale School of Medicine, 6Dresden University of Technology (TUD)

1732 Distance Affects Mortality on the Waitlist in Pediatric Liver Transplantation
Joel T. Adler, Yanik Bababekov, James F. Markmann, David C. Chang, Heidi Yeh
Massachusetts General Hospital

1733 AST-to-platelet ratio index in non-invasive assessment of long-term graft fibrosis following pediatric liver transplantation
Rashmi D'Souza1, Lara Neves Souza3, Alexander Isted1, Emer Fitzpatrick2, Sunitha Vimalesvaran2, Corina G. Cotoi3, Saista Amin2, Nigel Heaton4, Alberto Quaglia3, Anil Dhawan2
1King's College London School of Medicine, 2King's College Hospital, 3King's College Hospital, 4King's College Hospital

1734 Dynamics of pediatric liver allograft histological changes and the role of HLA, non-HLA antibodies
Sharat Varma3, Xavier Stephenne3, Françoise Smets3, Mina Komuta1, Jerome Ambroise2, Catherine de Magnée4, Dominique Latinne5, Raymond Reding4, Etienne M. Sokal3
1Cliniques universitaires St Luc, 2Université Catholique de Louvain (UCL), 3Cliniques universitaires St Luc, 4Cliniques universitaires St Luc, 5Cliniques universitaires St Luc

1735 Preformed and de novo DSA are not associated with acute cellular rejection in the early follow-up of pediatric liver transplant recipients
Dominique Schluckebier1, Laetitia Marie Petit1, Vladimir Cousin1, Anne-Laure Rougemont3, Jean Villard2, Dominique Belli1, Barbara E. Wildhaber4, Sylvie Ferrari-Lacraz2, Valerie A. McLin1
1 University Hospitals Geneva, 2University Hospitals Geneva, 3University Hospitals Geneva, 4University Hospitals Geneva

1736 Surveillance biopsies in pediatric liver transplant recipients to guide immunosuppression (IS) reduction
Amanda J. Posner1, Kuang-Yu Jen3, Linda Ferrell3, Anthony J. Demetris5, Sandy Feng4, Philip Rosenthal1, 4, Emily R. Perito1, 2
1University of California San Francisco, 2University of California San Francisco, 3University of California San Francisco, 4University of California San Francisco, 5University of Pittsburgh

1737 Epidemiology and outcomes of pediatric liver transplant recipients with multidrug resistant bacterial and fungal infections
Gillian Noel, Mark J. Abzug, Donna Curtis, Zhaoxing Pan, Shikha Sundaram
University of Colorado/Children's Hospital Colorado

1738 Immunization Practices Amongst Pediatric Transplant Hepatologists at SPLIT Centers
Amy G. Feldman1, 4, Shikha Sundaram1, 4, Brenda Beaty3, Allison Kempe2
1Children's Hospital Colorado, 2Children's Hospital Colorado, 3Adult and Child Center for Health Outcomes Research and Delivery Science, 4University of Colorado School of Medicine

Viral Hepatitis in Liver Transplant

1739 Detectable HBVDNA in liver allograft tissues has no clinical significance on long term follow up in liver transplant recipients under HBIg plus Antiviral prophylaxis
Deniz Mut1, Ilker Turan1, Deniz Nart2, Funda Yilmaz2, Selda Erensoy1, Ulus S. Akarca1, Galip Ersoz1, Fulya Gunsar1, Zeki Karasu1
1Ege University, 2Ege University

1740 HBV cccDNA evaluation in HBV-core antibody (HBcAb)-positive liver transplant donors
Gian Paolo Caviglia1, Francesco Tandoi2, 3, Maria Lorena Abate1, Alessia Ciancio1, 4, Renato Romagnoli2, 3, Antonina Smedile1, 4
1University of Turin, 2University of Turin, 3Città della Salute e della Scienza, Molinette Hospital, 4Città della Salute e della Scienza, Molinette Hospital

1741 The effect of ledipasvir/sofosbuvir on dose-normalized levels of immunosuppression in liver transplant recipients
Heather Johnson 1, 2, Alicia B. Lichvar2, Vinod k. Rustgi3
1University of Pittsburgh, 2UPMC Presbyterian, 3Thomas E. Starzle Transplantation Institute

1742 Liver Cancer in Patients Cured of Hepatitis C Virus: Less Cirrhosis and Less Fat than Expected
Chiara Rocha2, M. Isabel Fiel3, Erin H. Doyle1, Nicolas Goossens4, Yujin Hoshida4, Thomas D. Schiano2, Myron E. Schwartz2, Andrea D. Branch1
1Icahn School of Medicine at Mount Sinai, 2The Mount Sinai Hospital, 3The Mount Sinai Hospital, 4Icahn School of Medicine at Mount Sinai

1743 Treating HCV patients on the LT waiting list with Sofosbuvir plus Ribavirin is associated with clinical benefits and allows for safe assignement of older grafts to LT recipients
Maria Francesca Donato1, Daniele E. Dondossola2, Federica Malinverno1, Sara Monico1, Cristina Rigamonti1, Lucio Caccamo2, Alessio Aghemo1, Margherita Cavenago2, Giovanna Lunghi3, Barbara B. Antonelli2, Giorgio Rossi2, Massimo Colombo1
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 3Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

1744 Renal safety of nucleos(t)ide analogue monotherapy in HBV-exposed patients after liver transplantation
Anna Mrzljak, Ivana Carey, Sarah Knighton, Matthew J. Bruce, Mary Horner, Aisling B. Considine, Varuna Aluvihare, John G. O'Grady, Michael A. Heneghan, Kosh Agarwal, Abid Suddle
Kings College School of Medicine at King's College Hospital

1745 An Evidence-Based Algorithm to Optimize Patient Selection among Class III Obese Liver Transplant Waitlist Registrants
Ryan B. Perumpail1, Andy Liu2, Channa R. Jayasekera1, James H. Marcus4, 5, Swetha Tummala1, Sammy Saab3, Zobair M. Younossi4, 5, Robert J. Wong6, Aijaz Ahmed1
1Stanford University Medical Center, 2Albert Einstein College of Medicine, 3David Geffen School of Medicine at the University of California at Los Angeles, 4Inova Fairfax Hospital, 5Inova Health System, 6Alameda Health System - Highland Hospital Campus

1746 Long-term Outcome of Entecavir Monotherapy after Liver Transplantation for Chronic Hepatitis B
James Fung, Tiffany C. Wong, Cindy K. Cheung, Kenneth S. Chok, Wing-chiu Dai, Tan To Cheung, William Sharr, Albert Chan, Sui-Ling Sin, See-Ching Chan, Ching-Lung Lai, Man-Fung Yuen, Chung-Mau Lo
University of Hong Kong

1747 Prevalence and Clinical Impact of Hepatitis E Virus in Immunosuppressed Patient after Liver Transplantation
Stella De Nicola1, Maria F. Donato1, Caterina Premoli1, Giovanna Lunghi2, Patrizia Bono2, Matteo A. Manini1, Pietro Lampertico1, Federica Malinverno1, Sara Monico1, Paolo Reggiani3, Massimo Colombo1, Alessio Aghemo1
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, 2Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 3Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

1748 Long-term outcomes after hepatic resection for hepatocellular carcinoma in patients with sustained virological responses to interferon therapy for chronic hepatitis C
Shogo Tanaka1, Shigekazu Takemura1, Akihiro Tamori2, Masahiko Kinoshita1, Norifumi Kawada2, Shoji Kubo1
1Osaka City University Graduate School of Medicine, 2Osaka City University Graduate School of Medicine

1749 Effects of pre-transplant hepatitis C clearance on liver transplantation listing and wait time – a single center experience
Po-Hung Chen1, Mary G. Bowring2, Lauren M. Kucirka2, Christine M. Durand1, Andrew Ofosu2, Alia S. Dadabhai1, James P. Hamilton1, Andrew M. Cameron3, Dorry L. Segev3, Mark S. Sulkowski1, Ahmet Gurakar1
1Johns Hopkins University, 2Johns Hopkins University, 3Johns Hopkins University

1750 Protective Birth Cohort Effect in Baby Boomers Despite Presence of Poor Predictors
Ryan B. Perumpail1, Andy Liu2, Channa R. Jayasekera1, Zobair M. Younossi3, 4, Robert J. Wong5, Aijaz Ahmed1
1Stanford University Medical Center, 2Albert Einstein College of Medicine, 3Inova Fairfax Hospital, 4Inova Health System, 5Alameda Health System, Highland Hospital

1751 Prevention of post-transplant HCV recurrence by a 24 week regimen of Sofosbuvir/ribavirin (SOF/R) bridging pre-post transplant (b-ppT): a real life strategy
Maria F. Donato1, Sonia Berardi2, Rosa Maria Iemmolo3, Luca S Belli4, Marzia Montalbano5, Sherrie Bhoori6, Giulia Pieri7, Ilaria Lenci8, Alessandra Riva9, Veronica Bernabucci10, Sara Monico1, Chiara Mazzarelli4, Federica Malinverno1, Daniele E. Dondossola11, Chiara Taibi5, Giorgio Rossi11, Antonio Daniele Pinna17, Fabrizio Di Benedetto3, Luciano De Carlis13, Giuseppe M. Ettorre14, Vincenzo Mazzaferro6, Umberto Montin12, Giuseppe Tisone15, Marco Vivarelli16, Maria Rosa Tamè2, Paolo Caraceni18, Maria Cristina Morelli2
1Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 2St Orsola-Malpighi University Hospital, 3Azienda Ospedaliero Universitaria di Modena, 4Ospedale Niguarda Cà Granda, 5National Institute for Infectious Diseases "L. Spallanzani", 6Fondazione Istituto Nazionale Tumori IRCCS, 7IRCCS AO San Martino-IST-Genova , 8Università Tor Vergata Roma, 9AOU Ospedali Riuniti Ancona, 10Azienda Ospedaliero Universitaria di Modena, 11Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 12AO Universitaria Integrata Verona, 13Ospedale Niguarda Ca' Granda , 14National Institute for Infectious Diseases "L. Spallanzani" , 15Università Tor vergata Roma, 16AOU Ospedali Riuniti Ancona, 17St Orsola-Malpighi University Hospital, 18St Orsola-Malpighi University Hospital

1752 Hepatitis E infection in immunocompromised persons in Argentina
Jose Debes1, Maribel Martinez Wassaf 2, Maia Belen Pisano3, Leonardo Marianelli4, Martin Lotto3, Domingo Balderramo5, Hernan Coseano5, Viviana Re3
1University of MInnesota, 2Área de Virología y Biología Molecular, LACE Laboratorios, 3Instituto de Virología “Dr.J.M.Vanella”, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, 4Hospital Rawson, 5Hospital Privado

1753 Oral Interferon-free Antiviral Regimens in Liver Transplant Recipients with Hepatitis C: a Real Life Experience.
Arun Mannem2, 1, Shari S. Rogal2, Vivek Sharma2, Fadi Francis2, Thomas V. Cacciarelli2, Obaid S. Shaikh2, 1
1University of Pittsburgh School of Medicine, 2Veterans Affairs Pittsburgh Healthcare System

1754 Effect of simeprevir administration on dose-normalized concentration of calcineurin inhibitors in solid organ transplant recipients with hepatitis C infection
Heather Johnson 1, 2, Maxwell A. Brown2, Alicia B. Lichvar2, Michael A. Dunn1, Kapil B. Chopra1
1University of Pittsburgh, 2UPMC Presbyterian