The mission of the Liver Cell Biology in Hepatic Diseases SIG is:
- To advance and disseminate the science and practice of hepatology, and to promote liver health and quality patient care.
Activity Goals and Objectives
- Gain a greater understanding of basic cell biological functions of hepatic cells such as protein/lipid traffic, cytoskeletal organization, cellular polarity and receptor signaling cascades in health and disease. Pathological changes in cellular functions can translate into modulation of trafficking, cell adhesion and matrix production leading to liver damage, cholestasis and fibrogenic signals.
- Understand how the central processes listed above are altered and tailored to suit the highly specialized functions of the liver including regeneration, bile formation, secretion of essential plasma proteins, identification of biomarkers of disease progression and regulation of extracellular matrix turnover.
- Identify how hepatocellular functions are altered during hepatic diseases such as liver fibrosis and cancer.