Alcohol-Associated Liver Disease: From Prediction and Phenotyping to Transplantation and Population Trends

Description

This session presents advances across the spectrum of alcohol-associated liver disease. Talks span novel risk-stratification and mortality-prediction tools (an explainable AI decision-support model, metabolic/quantitative-fibrosis histophenotyping, and decompensation in AH), evolving practices in early liver transplantation, and pre-transplant psychosocial evaluation. Complementary epidemiologic analyses examine sex differences in alcohol consumption that may inform alcohol risk assessment and public health policy.

Presentations

2:00 PM - 2:15 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

AIM-AH: A Ministry supported multicentre Indian explainable AI decision support tool for risk stratification, referral, and early mortality prediction in alcohol-associated hepatitis

Nipun Dr Verma, MD, DM | Abstract Presenter
2:15 PM - 2:30 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Beyond MELD: Metabolic Risk Factor Burden and Quantitative Fibrosis Identify Distinct Histophenotypes and Predict Dose-Response Mortality in Alcohol-Associated Liver Cirrhosis (QFM-ALD Study)

Mohit Kumar Dr Varshney, MD, DM | Abstract Presenter
2:30 PM - 2:45 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Sex Differences in Alcohol Consumption: A Global Analysis of Prevalence Estimates and Drink Definition Heterogeneity

Ximena Parraga, MD | Abstract Presenter
2:45 PM - 3:00 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Genetic ancestry, PNPLA3, and per-drinker susceptibility to alcohol-associated cirrhosis: a multi-ancestry analysis of 414,830 All of US participants

Hyunseok Kim, MD, MPH, PhD | Abstract Presenter
3:00 PM - 3:15 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Early Liver Transplantation Is Universally Adopted but Pre-Transplant Psychosocial Protocols Remain Heterogeneous in the United States

Holly K Huang, MD | Abstract Presenter
3:15 PM - 3:30 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Decompensation Burden, Mortality, and Recompensation in Alcohol-Associated Hepatitis 

Kavish Patidar, END | Abstract Presenter

Objectives

  • Evaluate the role of explainable AI and quantitative histologic/metabolic markers in risk stratification and mortality prediction for alcohol-associated hepatitis and cirrhosis
  • Describe current practices and remaining variability in early liver transplantation for alcohol-associated liver disease, including pre-transplant psychosocial evaluation protocols
  • Describe decompensation features of alcohol-associated hepatitis and rates and predictors of recompensation
  • Interpret recent epidemiologic trends in sex-based differences in alcohol consumption to inform clinical and public health strategies