MTE #21: Porto-Sinusoidal Vascular Disorder (Ticketed)

Porto-sinusoidal vascular disorder (PSVD) has recently undergone a major conceptual shift with changes in both its name and diagnostic definition, accompanied by the development of a new diagnostic score. Despite these advances, PSVD remains a frequently underdiagnosed and misdiagnosed condition with limited awareness across clinical settings. Disease mechanisms, natural history, and trajectories are still incompletely understood; significant gaps remain in patient identification and cohort harmonization. Experts review the evolving definition of PSVD; discuss the rationale and application of the new diagnostic criteria and scoring system; and examine current challenges in diagnosis, phenotyping, and disease classification. Through expert insights and case-based discussion, the session highlights unmet needs in understanding PSVD pathophysiology and clinical course, and outlines priorities for improving recognition, diagnosis, and collaborative research efforts.