Precision Hepatology in Children: Novel Therapies, Biomarkers, and Clinical Outcomes

Description

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This session highlights emerging advances in pediatric hepatology, spanning gene-editing therapies, cancer biology, immune-mediated liver injury, transplant-related complications, and innovative biomarker approaches. Presentations showcase translational research and clinical studies that are advancing precision diagnosis, prognostication, and treatment of pediatric liver diseases.

Presentations

11:00 AM - 11:15 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

UCA1 long noncoding RNA in cisplatin resistant hepatoblastoma

Maryam G Shaikh, PhD | Abstract Presenter
11:15 AM - 11:30 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

UTILISATION OF THROMBOELASTOGRAPHY AND AND von WILLEBRAND FACTOR ANTIGEN PROFILE IN CHILDREN WITH BLEEDING IN LIVER TRANSPLANT

Harry Sutton | Abstract Presenter
11:30 AM - 11:45 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Blood CD8 Tissue Resident Memory-like endotypes persist throughout disease course in patients with activated T-cell pediatric acute liver failure

Tamir Diamond, MD, MSTR | Abstract Presenter
11:45 AM - 12:00 PM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Outcomes Benchmarks in Pediatric Autoimmune Liver Disease: A Foundation and a Challenge for Improvement from the Autoimmune Liver Disease Network for Kids (A-LiNK)

Amy E Taylor, MD | Abstract Presenter
12:00 PM - 12:15 PM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Integrated Imaging and Plasma Biomarkers for Detection of Ductal Disease and Fibrosis in Pediatric Autoimmune Liver Disease 

Tamar Ogard, MD | Abstract Presenter
12:15 PM - 12:30 PM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

The Natural History, Clinical and Laboratory Predictors of Survival and Portal Hypertension in Pediatric Fontan-Associated Liver Disease (FALD): A Multicenter PED FALD Network 

Chaowapong Jarasvaraparn, MD | Abstract Presenter

Objectives

  • Describe emerging precision medicine approaches for pediatric liver diseases, including gene-editing therapies, molecular targets, and novel treatment strategies
  • Evaluate the role of advanced biomarkers, imaging, and immunologic profiling in the diagnosis, prognostication, and monitoring of pediatric liver disorders
  • Discuss recent advances in clinical outcomes research across pediatric liver transplantation, autoimmune liver disease, acute liver failure, and other chronic liver conditions to inform patient management and future research