This interactive discussion explores the complexities of managing hepatitis B in pregnancy, highlighting the key differences in approaches between Asia and Western countries. Presentation topics include: insights into region-specific guidelines; antiviral therapy options; neonatal immunoprophylaxis strategies; and the influence of cultural and health care system factors on care delivery. By comparing practices across regions, the session provides practical knowledge to optimize outcomes for pregnant women with hepatitis B and their newborns in diverse clinical settings.