Basic Science Workshop, Part 2: Decoding Liver Biology Through Spatial Multi-Omics: From Architecture to Disease Mechanisms

The spatial organization and zonation of the liver are fundamental to its functions and ability to repair and regenerate. Disruption of this spatial organization during inflammation and injury impairs hepatic function contributing to chronic liver diseases. Recent advances in spatial multi-omic technologies now allow researchers to visualize how gene expression and cellular pathways vary across hepatic zones, revealing how structural context governs metabolic specialization, regenerative capacity, and disease susceptibility. This 2-part workshop brings together leading experts applying these technologies to investigate the liver in health and disease. Presentations encompass the mechanisms that preserve tissue organization and support repair to the cellular interactions driving fibrosis and metabolic dysfunction. Attendees learn how spatial transcriptomic, proteomic, lipidomic, and epigenomic analyses are redefining our understanding of liver biology and opening new avenues for biomarker discovery and therapeutic innovation.