Clinical Plenary #1

Nov 07 2026
Convention Center: General Session, Hall A
8:30 AM - 9:30 AM
Captured/recorded session Recorded
CE Credits CE Credits

Description

Very recent experiences of gene therapy for non-liver disorders has, in rare cases, led to several serious hepatic toxicities including liver failure.  Understanding hepatic pathophysiology, monitoring and therapeutic approaches in the modern era of gene therapy is crucial.

Presentations

8:30 AM - 8:45 AM
Convention Center - General Session, Hall A
Recorded session

CRISPR-Cas12 Based Gene Editing Therapy for Primary Hyperoxaluria Type 1: a phase 1 clinical trial

Taihua Yang, PhD | Abstract Presenter
8:45 AM - 9:00 AM
Convention Center - General Session, Hall A
Recorded session

BULEVIRTIDE MONOTHERAPY PREVENTS LIVER DECOMPENSATION IN HDV-RELATED CIRRHOSIS: 3-YEAR RESULTS FROM A EUROPEAN, RETROSPECTIVE, CONTROLLED COHORT STUDY

Elisabetta Degasperi | Abstract Presenter
9:00 AM - 9:15 AM
Convention Center - General Session, Hall A
Recorded session

Decoupling of Disease Activity and Fibrosis in MASH: Insights from Contemporary Biopsy Cohorts in the GLP-1 Receptor Agonist Era

Winston Dunn, MD, , FAASLD | Abstract Presenter
9:15 AM - 9:30 AM
Convention Center - General Session, Hall A
Recorded session

GLP1R Gene Variants Modify Longitudinal Outcomes and GLP1 Receptor Agonist Response in MASLD: A Whole-Genome Sequencing Pharmacogenomic Study

Sarpong Boateng, MD, MPH | Abstract Presenter

Objectives

  • Explain Phase 1 outcomes for gene therapy for primary hyperoxaluria
  • Understand roles for GLP1 Receptor gene variants in MASLD progression and response to GLP1 receptor agonist therapies.
  • Understand clinical responses to bulevirtide for HDV-related cirrhosis