Genomics and Precision Medicine

Description

This session presents genomic and molecular discoveries in liver disease, spanning cirrhosis risk loci, single-cell/spatial transcriptomics in hepatoblastoma, and population-scale genetic variant studies in MASLD and HCC.

Presentations

5:00 PM - 5:15 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

meta-analysis of alcohol-associated liver cirrhosis identified new risk loci

Callie J Zaborenko, PhD | Abstract Presenter
5:15 PM - 5:30 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

Loss of Y chromosome is a novel somatic aneuploidy and potential biomarker in hepatocellular carcinoma 

Gopanandan Parthasarathy, MBBS | Abstract Presenter
5:30 PM - 5:45 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

Multi-ancestry whole-genome study identifies population-specific effects of PNPLA3, TM6SF2, MBOAT7, HSD17B13, and MARC1 on cirrhosis, MASLD, and hepatocellular carcinoma in 414,830 All of Us participants

Hyunseok Kim, MD, MPH, PhD | Abstract Presenter
5:45 PM - 6:00 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

Epigenetic-Metabolic Phospholipid Reprogramming by BAP1 Loss Confers Cholangiocarcinoma Resistance to Ferroptosis

Yu Zhao, PhD | Abstract Presenter
6:00 PM - 6:15 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

Single-Cell, Single-Nuclei, and Spatial Transcriptomics Reveals Signature-Specific Microenvironments in Hepatoblastoma

Abhishek Murti, MS | Abstract Presenter
6:15 PM - 6:30 PM
Convention Center - Bluebird Ballroom 2DEF
Recorded session

SPATIALLY RESOLVED LINEAGE PROGRAMS DEFINE PROGNOSIS, THERAPEUTIC VULNERABILITIES, AND STROMAL CROSSTALK IN INTRAHEPATIC CHOLANGIOCARCINOMA

KENTA MAKINO, MD, PhD | Abstract Presenter

Objectives

  • Describe how large-scale genomic studies are identifying novel risk variants relevant to liver disease susceptibility.