Acute Liver Failure: From Mechanistic Insights to Emerging Liver Support Strategies

Nov 10 2025
Convention Center: Room 146B, Level 1
11:00 AM - 12:30 PM

World Class Speakers

Deirdre A Kelly Professor, MD, FAASLD
Moderator

Deirdre A Kelly Professor, MD, FAASLD

University of Birmingham
William Bernal, MD, FAASLD, FRCP
Moderator

William Bernal, MD, FAASLD, FRCP

King's College Hospital

Description

This session will explore the rapidly evolving landscape of acute liver failure (ALF), addressing both the underlying pathophysiological mechanisms and cutting-edge approaches to liver support. Participants will gain insights into the immunological and metabolic contributors to ALF, including novel findings in pyroptosis and immune cell activation, as well as comorbid factors in drug-induced liver injury. The session will also highlight therapeutic innovations, including bioartificial liver systems, stem cell-derived hepatocyte technologies, and therapeutic plasma exchange. Through clinical trials and translational research, this session aims to bridge the gap between bench and bedside in the management of ALF.

Journey Maps

Objectives

  • Understand emerging cellular and immune mechanisms involved in acute liver failure, including inflammasome activation, macrophage polarization, and T-cell dysregulation.
  • Evaluate the current and future role of artificial and bioartificial liver support systems, including outcomes from recent clinical trials and preclinical studies.
  • Recognize the influence of comorbid factors such as viral infections and metabolic dysfunction in drug-induced liver injury and their implications for ALF diagnosis and management.