Basic Science Symposium: Endothelial Cells Occupy Center Stage in Liver Disease, Part 1—Endothelial Cell Physiology and Heterogeneity

Description

Presenters in this symposium focus on the varied functions of liver endothelial cells (ECs). ECs are specialized cells increasingly recognized for their heterogeneity and their key role in liver diseases and carcinogenesis. Recent advances in the understanding of EC function were made possible with refined isolation techniques coupled with multiomics studies. Speakers review emerging literature that defines liver ECs beyond their role as vascular barriers to critical mediators in various biological processes under physiologic and pathologic conditions. 

Journey Maps

Presentations

8:00 AM - 8:20 AM
Nov 07 2025
Washington, D.C.

Liver Sinusoidal Endothelial Cells: Specialized Endothelial Cells With Pleotropic Functions

Karen Kristine Sørensen, DVM, PhD, Presenter
Basic Science
8:40 AM - 9:00 AM
Nov 07 2025
Washington, D.C.

Liver Lymphatic Endothelial Cells in Health and Disease

Yasuko Iwakiri, PhD, FAASLD, Presenter
Basic Science
9:00 AM - 9:30 AM
Nov 07 2025
Washington, D.C.

Q&A and Panel Discussion

Matthew A Burchill, PhD, Moderator
Basic Science

Objectives

  • Describe the unique structural and functional characteristics of liver endothelial cells and their heterogeneity.
  • Identify the key role of liver endothelial cells in acute and chronic liver diseases and the potential for therapeutic targeting.
  • Review the immunological functions of liver sinusoidal endothelial cells.
Chair

Jordi Gracia-Sancho, PhD, FAASLD

IDIBAPS - Hospital Clínic Barcelona
Chair

Samar H Ibrahim, MBCHB, FAASLD

Mayo Clinic Rochester