Basic Science Symposium: Endothelial Cells Occupy Center Stage in Liver Diseases, Part 2—Endothelial Cells in Acute Liver Injury and Inflammation

Description

Presenters in this symposium focus on the varied functions of liver endothelial cells (ECs). ECs are specialized cells increasingly recognized for their heterogeneity and their key role in liver diseases and carcinogenesis. Recent advances in the understanding of EC function were made possible with refined isolation techniques coupled with multiomics studies. Speakers review emerging literature that defines liver ECs beyond their role as vascular barriers to critical mediators in various biological processes under physiologic and pathologic conditions. 

Journey Maps

Presentations

11:00 AM - 11:20 AM
Nov 07 2025
Washington, D.C.

Ischemia Reperfusion Injury and Liver Regeneration

Satdarshan (Paul) Monga, MD, FAASLD, Presenter
Basic Science
11:20 AM - 11:40 AM
Nov 07 2025
Washington, D.C.

Mechanisms Linking Microvascular Hemostasis to Drug-Induced Liver Injury

James Luyendyk, PhD, Presenter
Basic Science
11:40 AM - 12:00 PM
Nov 07 2025
Washington, D.C.

Liver Sinusoidal Endothelial Cell as an Orchestrator of the Gut-Liver Immune Axis

Esther Caparrós, PhD, Presenter
Basic Science
12:00 PM - 12:30 PM
Nov 07 2025
Washington, D.C.

Q&A and Panel Discussion

Satdarshan (Paul) Monga, MD, FAASLD, Moderator
Basic Science

Objectives

  • Identify the key role of liver endothelial cells in acute and chronic liver diseases and the potential for therapeutic targeting.
  • Review the immunological functions of liver sinusoidal endothelial cells.
  • Define the role of liver sinusoidal endothelial cells in portal hypertension, fibrosis progression, and carcinogenesis.
Chair

Jordi Gracia-Sancho, PhD, FAASLD

IDIBAPS - Hospital Clínic Barcelona
Chair

Samar H Ibrahim, MBCHB, FAASLD

Mayo Clinic Rochester