Basic Science Symposium: Endothelial Cells Occupy Center Stage in Liver Diseases, Part 3—Endothelial Cells in Chronic Liver Diseases
Nov
07
2025
Convention Center: Ballroom A, Level 3
2:00 PM - 3:30 PM
Description
Presenters in this symposium focus on the varied functions of liver endothelial cells (ECs). ECs are specialized cells increasingly recognized for their heterogeneity and their key role in liver diseases and carcinogenesis. Recent advances in the understanding of EC function were made possible with refined isolation techniques coupled with multiomics studies. Speakers review emerging literature that defines liver ECs beyond their role as vascular barriers to critical mediators in various biological processes under physiologic and pathologic conditions.Journey Maps
Presentations
2:00 PM - 2:20 PM
Nov
07
2025
Washington, D.C.
Lipotoxic Endotheliopathy in Metabolic Dysfunction-Associated Steatohepatitis
Samar H Ibrahim, MBCHB, FAASLD, Presenter
Basic Science
2:20 PM - 2:40 PM
Nov
07
2025
Washington, D.C.
Liver Sinusoidal Endothelial Cells Amplify the Inflammatory Response in Alcholol-Related Steatohepatitis
Mengfei Liu, MD, Presenter
Basic Science
2:40 PM - 3:00 PM
Nov
07
2025
Washington, D.C.
Liver Sinusoidal Endothelial Cells Modulate Acute-on-Chronic Liver Failure
Irina Tikhanovich, PhD, Presenter
Basic Science
3:00 PM - 3:30 PM
Nov
07
2025
Washington, D.C.
Q&A and Panel Discussion
Natalia Nieto, PhD, Moderator
Basic Science
Objectives
- Identify the key role of liver endothelial cells in acute and chronic liver diseases and the potential for therapeutic targeting.
- Review the immunological functions of liver sinusoidal endothelial cells.
- Define the role of liver sinusoidal endothelial cells in portal hypertension, fibrosis progression, and carcinogenesis.
Chair
Yasuko Iwakiri, PhD, FAASLD
Yale University