Basic Science Symposium: Endothelial Cells Occupy Center Stage in Liver Diseases, Part 4—Endothelial Cells in Portal Hypertension, Liver Fibrosis, and Carcinogenesis

Description

Presenters in this symposium focus on the varied functions of liver endothelial cells (ECs). ECs are specialized cells increasingly recognized for their heterogeneity and their key role in liver diseases and carcinogenesis. Recent advances in the understanding of EC function were made possible with refined isolation techniques coupled with multiomics studies. Speakers review emerging literature that defines liver ECs beyond their role as vascular barriers to critical mediators in various biological processes under physiologic and pathologic conditions.

Journey Maps

Presentations

4:00 PM - 4:20 PM
Nov 07 2025
Washington, D.C.

Endothelial Cells in Metabolism and Mechanobiology

Vijay H. Shah, MD, FAASLD, Presenter
Basic Science
4:20 PM - 4:40 PM
Nov 07 2025
Washington, D.C.

Endothelial Cells in Fibrosis and Portal Hypertension

Jordi Gracia-Sancho, PhD, FAASLD, Moderator
Basic Science
4:40 PM - 5:00 PM
Nov 07 2025
Washington, D.C.

Liver Angiogenesis and Carcinogenesis

Jesus Maria M Gomez Salinero, PhD, Presenter
Basic Science
5:20 PM - 5:30 PM
Nov 07 2025
Washington, D.C.

Q&A

Jordi Gracia-Sancho, PhD, FAASLD, Moderator
Basic Science

Objectives

  • Identify the key role of liver endothelial cells in acute and chronic liver diseases and the potential for therapeutic targeting.
  • Review the immunological functions of liver sinusoidal endothelial cells.
  • Define the role of liver sinusoidal endothelial cells in portal hypertension, fibrosis progression, and carcinogenesis.
Chair

Samar H Ibrahim, MBCHB, FAASLD

Mayo Clinic Rochester
Chair

Yasuko Iwakiri, PhD, FAASLD

Yale University