Cellular Signaling and Metabolic Regulation in Chronic Liver Disease
Nov
09
2025
Convention Center: Room 146A, Level 1
8:00 AM - 9:30 AM
Description
This session explores the intricate signaling pathways and metabolic networks that govern liver injury, repair, and chronic disease progression. Presentations will cover hepatocyte-stellate cell interactions, nuclear receptor signaling, autophagy zonation, and the molecular regulation of regeneration and fibrosis. Through multiomics and tissue-specific analyses, these studies illuminate how dysregulation of cellular communication and metabolism contributes to conditions such as steatohepatitis, fibrosis, sarcopenia, and Type II diabetes.
Objectives
- Identify key signaling pathwaysincluding Wnt/-catenin, -arrestin, and nuclear receptorsthat regulate liver regeneration, fibrosis, and metabolic balance.
- Describe how cell-specific transcriptional and metabolic regulation contributes to chronic liver disease states such as steatohepatitis, cirrhosis, and diabetes.
- Evaluate emerging molecular insights from multiomics and zonation analyses to understand the cellular complexity of liver pathophysiology.