This presentation delves into the molecular intricacies of hepatic lipid metabolism and lipotoxicity in metabolic dysfunction associated steatotic liver disease and alcohol associated hepatitis. We will review the critical mechanistic role lipids play in liver injury and inflammation in the development of steatotic liver disease. By decoding the hepatic lipid code, the presentation aims to unveil potential therapeutic strategies. Attendees will gain insights into cutting-edge mechanisms and approaches to address liver steatosis effectively.