Explore hepatocellular carcinoma (HCC) through the lens of living with a chronic disease. From the time of HCC diagnosis, most patients are faced with undergoing lifelong surveillance with regular multiphasic imaging studies and, often, undergoing multiple rounds of treatment including different types of locoregional and systemic therapies. This exacts a substantial toll on quality of life, limits the ability to participate in work and family-related activities, and imposes great symptom, psychological, physical, and financial burdens. Speakers focus on the importance of patients preparing for the long-term trajectory of liver cancer and for physicians to support them in their journey.