Achieving optimal health during our patients’ lifetimes is not something that should occur only after a provider recognizes liver disease. It is best understood and approached by incorporating the many facets of each patient’s past history, genetics, environment, medications, and other exposures that change during the course of their lives. The theme of this postgraduate course is to frame the way we approach patients and their liver care in the context of their current stage of life, while also taking into account past contributions as well as preparing for the future. As such, this course reframes information and teaching points—age, disease, surveillance, screening, extrahepatic contributions, and treatments all tied together as a continuum. The speakers present their approaches and complexities to each disease or intervention through the lens of a lifetime for each of the topics. Components include pregnancy and early life contributors, extrahepatic manifestations, alcohol use, and a full session on the aging patient. Taken together, this course intends to enhance the attendee's understanding, approach, and planning for their individual patient’s needs to achieve optimal liver-centric health at all stages of their lives. The sessions include: Lifelong Age-Appropriate Screening, Surveillance and Therapeutic Choices; Extrahepatic Contributors to Liver Health Outcomes; The Die Is Cast at a Young Age—Early Life Determinants of Future Liver Health; and Liver Health in Older Adults.
Session 1 (8:00 AM - 9:45 AM): Lifelong age-appropriate screening, surveillance and therapeutic choices
Session 2 (11:00 AM - 12:40 PM): Liver Cancers—New Solutions for Old Problems
Session 3 (2:00 PM - 3:40 PM): The die is cast at a young age: early life determinants of future liver health
Session 4 (4:00 PM - 5:30 PM): Liver health in the older adults
Metabolic Dysfunction-Associated Steatohepatitis and MetALD
Mary Rinella, MD, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
8:25 AM - 8:45 AM
Nov
07
2025
San Diego, CA
Cholestatic Liver Disease
Michael Trauner, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
8:45 AM - 9:05 AM
Nov
07
2025
San Diego, CA
Viral Hepatitis
Raymond T Chung, MD, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
9:05 AM - 9:25 AM
Nov
07
2025
San Diego, CA
Hepatocellular Carcinoma
Neehar D. Parikh, MD, MS, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
9:25 AM - 9:45 AM
Nov
07
2025
San Diego, CA
Q&A and Panel, Session 1
Amit G Singal, MD, MS, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
11:00 AM - 11:20 AM
Nov
07
2025
San Diego, CA
Diet, Health, and Exercise in Chronic Liver Disease
Shira Zelber-Sagi, PhD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
11:20 AM - 11:40 AM
Nov
07
2025
San Diego, CA
Metabolic Dysfunction-Associated Steatotic Liver Disease Effects on the Brain, Heart, Pancreas, and Other Organs
Arun J Sanyal, MD, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
11:40 AM - 12:00 PM
Nov
07
2025
San Diego, CA
Alcohol Use Disorder Treatment Across the Spectrum of Liver Disease
Ramon Bataller, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:00 PM - 12:20 PM
Nov
07
2025
San Diego, CA
The Kidneys in Cirrhosis: Beyond Hepatorenal Syndrome
Sumeet K. Asrani, MD MSc, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:20 PM - 12:40 PM
Nov
07
2025
San Diego, CA
Q&A and Panel, Session 2
Naga P Chalasani, MD, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
2:00 PM - 2:20 PM
Nov
07
2025
San Diego, CA
Pregnancy and Liver Disease
Carla W Brady, MD, MHS, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
2:20 PM - 2:40 PM
Nov
07
2025
San Diego, CA
Early Contributors to Dysmetabolism in Infants and Children
Marialena Mouzaki, MD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
2:40 PM - 3:00 PM
Nov
07
2025
San Diego, CA
Genetic Contributions to Liver Disease
Silvia Vilarinho, MD, PhD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
3:00 PM - 3:20 PM
Nov
07
2025
San Diego, CA
Autoimmune Liver Diseases That Start in Childhood
Gideon M Hirschfield, MB BChir, PhD, FRCP (Lon), Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
3:20 PM - 3:40 PM
Nov
07
2025
San Diego, CA
Q&A and Panel, Session 3
Ronald J Sokol, MD, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
4:00 PM - 4:20 PM
Nov
07
2025
San Diego, CA
Altered Drug Metabolism and Drug-Induced Liver Disease in Older Adults
Lily Dara, MD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
4:20 PM - 4:40 PM
Nov
07
2025
San Diego, CA
Liver Disease as a Contributor to Dementia
Jasmohan S. Bajaj, MD, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
4:40 PM - 5:00 PM
Nov
07
2025
San Diego, CA
Palliative Care and Symptom-Based Management
Fasiha Kanwal, MD, MSHS, AGAF, FAASLD, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
5:00 PM - 5:20 PM
Nov
07
2025
San Diego, CA
Transplant Selection in Older Adults
Jennifer C Lai, MD, MBA, Presenter
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
5:20 PM - 5:30 PM
Nov
07
2025
San Diego, CA
Q&A and Panel, Session 4
Robert J. Fontana, MD, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:39 AM - 12:39 AM
Nov
07
2025
San Diego, CA
Introduction, Session 1
Norah Terrault, MD, MPH, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:39 AM - 12:39 AM
Nov
07
2025
San Diego, CA
Introduction, Session 3
Monika Sarkar, MD, FAASLD, MAS, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:39 AM - 12:39 AM
Nov
07
2025
San Diego, CA
Introduction, Session 4
Tamar H Taddei, MD, MD, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
12:39 AM - 12:39 AM
Nov
07
2025
San Diego, CA
Introduction, Session 2
Meena B Bansal, MD, FAASLD, Moderator
ALD
Hepatitis
Liver Cancer
MASLD
Transplant
Objectives
Characterize and compare the stages and approaches to viral, cholestatic, and metabolic liver disease over the lifetime of patients with liver disease.
Recognize the contributors to liver disease in adults from genetic and acquired contributions during pregnancy, childhood, and young adulthood.
Describe the extrahepatic manifestations of health in patients with liver disease, including diet, endocrine, alcohol use, and the kidneys.
Review the unique and specific issues for liver biology, drug use, mental health, drug-induced liver injury, and liver disease therapeutic modifications in older adults.
Chair
Mazen Noureddin, MD, MHSc
Houston Methodist Hospital
Chair
Elizabeth C Verna, MD, MS, FAASLD
Columbia University Medical Center
Chair
Saul Karpen, MD, PhD, FAASLD
VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health