America’s dominance in medical research over the last few decades has been remarkable, with exponentially increasing advances that have saved millions of lives and reduced suffering. Yet dark clouds are now around us. NIH support for basic and translational research in US research universities is under attack. And even for breakthroughs that have happened, our broken health care system is not always able to deliver therapies for conditions like sickle cell anemia and hepatitis C. But there is hope. Americans are waking up to the fact that these attacks on medical research are not what they want for themselves and their families, and creative solutions are being developed to deliver cures to those who need them.