Signals Across Systems: Microbiome, Immunity, and Neuroinflammation in Liver Disorders
Nov
10
2025
Convention Center: Room 146A, Level 1
8:00 AM - 9:30 AM
Description
This session explores the complex, multisystem interactions that drive inflammation in liver disease, with a focus on gut-liver and liver-brain communication. Presentations highlight the roles of the microbiome in estrogen homeostasis, salivary and serum biomarkers in cirrhosis outcomes, and immune signaling pathways such as TLR8 and neutrophil recruitment in biliary and advanced liver disease. The session also delves into how hepatocyte-derived exosomes and β/γ-catenin signaling impact microbiome balance, intestinal inflammation, and neuroinflammation, underscoring new therapeutic opportunities at the interface of immunity and inter-organ communication.Objectives
- Describe how gut and salivary microbiomes influence systemic inflammation and clinical outcomes in chronic liver disease.
- Explain the roles of exosome-mediated signaling and immune cell activation in liver-to-brain and liver-to-gut communication.
- Evaluate emerging anti-inflammatory targetsincluding TLR8, neutrophil pathways, and /-catenin signalingfor their potential to modulate disease progression across organ systems.