Small Molecules, Big Consequences: Mechanisms of Hepatoxicity

Nov 09 2025
Convention Center: Ballroom C, Level 3
11:00 AM - 12:30 PM

World Class Speakers

Dina Halegoua-DeMarzio, MD
Moderator

Dina Halegoua-DeMarzio, MD

Thomas Jefferson University Hospital
Paul H Hayashi, MD, MPH, FAASLD
Moderator

Paul H Hayashi, MD, MPH, FAASLD

FDA

Description

This session highlights novel basic science research investigating mechanisms of hepatoxicity. This session spans liver injury and repair for a variety of disease models including acetaminophen-induced liver injury, ethanol hepatoxicity, induction of tumorgenesis and HCC, and the role of coagulation in severe acute liver injury. 

Journey Maps

Objectives

  • Describe key pathways for inflammation and recovery in acetaminophen-induced liver injury.
  • Discuss the interplay of metabolic factors, ammonia production, and development of HCC in pre-clinical models.
  • Outline the interplay of immune cells in drug toxicity and liver recovery.