This session comprises a critical discussion of the most notable and influential clinical research papers published in HEPATOLOGY in the past year by a team of associate editors from the journal HEPATOLOGY. Associate editors Yujin Hoshida, Jennifer Lai, and Manal Abdelmalek appraise the most cutting-edge, game-changing clinical science research literature. A panel discussion with the speakers, editor-in-chief Gregory Gores, and associate editor Jacqueline O’Leary highlights the clinical impact of selected papers and key challenges and opportunities in the field.