Associate editors from the journal HEPATOLOGY lead a critical discussion of the most notable and influential translational research papers published in the past year. HEPATOLOGY associate editors Kari Nejak-Bowen, Natalie Torok, and Samar Ibrahim appraise the most cutting-edge, game-changing scientific advances. A panel discussion with the speakers, editor-in-chief Gregory Gores, and deputy editor Harmeet Malhi highlights the impact of selected papers on translational advances in the field.