Continuing the successful AASLD-KASL collaboration underway since 2023, this session highlights practice-changing innovations in hepatology from leading researchers in the U.S. and Korea. Topics include the application of artificial intelligence for non-invasive assessment of liver fibrosis in patients with MASLD, the use of speech pattern analysis as a digital biomarker for detecting hepatic encephalopathy, clinical data on autologous bone marrow-derived mesenchymal stem cell transplantation for liver cirrhosis, and AI-powered tools that synthesize clinical guidelines to support real-time decision-making. A panel discussion will follow to explore the clinical impact, implementation challenges, and global relevance of these emerging technologies.