Cellular Signaling and Metabolic Regulation in Chronic Liver Disease
Nov
09
2025
Convention Center: Room 146A, Level 1
8:00 AM
- 9:30 AM
Description
This session explores the intricate signaling pathways and metabolic networks that govern liver injury, repair, and chronic disease progression. Presentations will cover hepatocyte-stellate cell interactions, nuclear receptor signaling, autophagy zonation, and the molecular regulation of regeneration and fibrosis. Through multiomics and tissue-specific analyses, these studies illuminate how dysregulation of cellular communication and metabolism contributes to conditions such as steatohepatitis, fibrosis, sarcopenia, and Type II diabetes.Journey Maps
Presentations
8:00 AM
- 8:15 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
Beta-arrestin-2-mediated hepatocyte-HSC interaction promotes HSC activation and fibrogenesis
Romina Fiorotto, PhD
, Abstract Presenter
Basic Science
8:15 AM
- 8:30 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
Targeting LRH-1 in Mice Promotes Liver Homeostasis and Inflammatory Attenuating Transcriptional Profiles to Ameloriate TypeII Diabetes
Wen-Xing Ding, MD, PhD, FAASLD
, Abstract Presenter
Basic Science
8:30 AM
- 8:45 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
PPAR gamma regulates PNPLA3 in a tissue specific manner in obese people and mice with metabolic dysfunction-associated steatohepatitis
Romina Fiorotto, PhD
, Abstract Presenter
Basic Science
8:45 AM
- 9:00 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
Multiomics analysis Reveals MyD88-dependent Inhibition of mitochondrial oxidative function during hyperammonemic stress causes sarcopenia of cirrhosis
Wen-Xing Ding, MD, PhD, FAASLD
, Abstract Presenter
Basic Science
9:00 AM
- 9:15 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
Spatial Organellomics: A New Window into Hepatocyte Subtypes, Zonal Diversity, and Disease Progression
Romina Fiorotto, PhD
, Abstract Presenter
Basic Science
9:15 AM
- 9:30 AM
Aug
06
2026
Convention Center - Room 146A, Level 1
Transcriptional Regulation of the Hepatic Acetylome by Nrf2 in Autophagy-Impaired Liver
Wen-Xing Ding, MD, PhD, FAASLD
, Abstract Presenter
Basic Science
Objectives
- Identify key signaling pathwaysincluding Wnt/-catenin, -arrestin, and nuclear receptorsthat regulate liver regeneration, fibrosis, and metabolic balance.
- Describe how cell-specific transcriptional and metabolic regulation contributes to chronic liver disease states such as steatohepatitis, cirrhosis, and diabetes.
- Evaluate emerging molecular insights from multiomics and zonation analyses to understand the cellular complexity of liver pathophysiology.