Distinct Pathways, Shared Progress: Metabolic/Genetic Disorders & Biliary Physiology
Nov
09
2025
Convention Center: Room 145, Level 1
8:00 AM
- 9:30 AM
Description
This session highlights innovations from molecular mechanisms to drug development and clinical trials in biliary physiology and genetic and metabolic conditions. This session will spotlight cholangiocyte biology from scaffolding to repair. These research presentations will provide insights into mechanisms and therapeutics for A1AT deficiency, Wilson Disease, and hemachromatosis.Journey Maps
Presentations
8:30 AM
- 8:45 AM
Aug
06
2026
Convention Center - Room 145, Level 1
Inducible dual loss of β- and γ-catenin in bile ducts leads to cholestatic injury and mortality or repair based on the extent of cell junction loss
Vik Meadows, PhD
, Abstract Presenter
Basic Science
8:45 AM
- 9:00 AM
Aug
06
2026
Convention Center - Room 145, Level 1
New insights into pathogenic mechanisms of liver fibrosis in hemochromatosis
Grace L Guo, MBBS, PhD
, Abstract Presenter
Basic Science
9:15 AM
- 9:30 AM
Aug
06
2026
Convention Center - Room 145, Level 1
Artificial intelligence-based qFibrosis® analysis correlates with changes in histological features in alpha-1 antitrypsin deficiency-associated liver disease following treatment with fazirsiran
Grace L Guo, MBBS, PhD
, Abstract Presenter
Basic Science
Objectives
- Evaluate emerging therapies for metabolic and genetic liver disease.
- Describe basic science mechanisms of cholangiocyte development and repair and their implications for therapeutic targets.
- Discuss basic, translational, and clinical studies for treatment of biliary disorders and genetic/metabolic liver disease.