Emerging public health data suggest that our environment—the surroundings or conditions in which we live, work, and play—may have substantial impact on the epidemiology of liver disease and the liver health of our communities. In some cases, research in this field may be conflicting, limited in scope, or difficult to translate into clinical practice leading to substantial uncertainty around patient counseling and messaging, and from patients themselves. Presenters summarize and interpret existing research on environmental exposures and liver disease and liver health, including on the development and progression of malignant (HCC and non-HCC primary liver cancers) and nonmalignant (hepatic steatosis, inflammation, fibrosis, and cirrhosis) liver disease.