Signals Across Systems: Microbiome, Immunity, and Neuroinflammation in Liver Disorders

Nov 10 2025
Convention Center: Room 146A, Level 1
8:00 AM - 9:30 AM

World Class Speakers

Jasmohan S. Bajaj, MD, FAASLD
Abstract Presenter

Jasmohan S. Bajaj, MD, FAASLD

Virginia Commonwealth University
Gyongyi Szabo, MD, PhD, FAASLD
Abstract Presenter

Gyongyi Szabo, MD, PhD, FAASLD

Beth Israel Deaconess Medical Center
Romina Fiorotto, PhD
Abstract Presenter

Romina Fiorotto, PhD

Yale University
Bilon Dr Khambu, MSc, PhD
Moderator

Bilon Dr Khambu, MSc, PhD

Tulane University School of Medicine
Maria Serena Longhi, MD, PhD
Moderator

Maria Serena Longhi, MD, PhD

Beth Israel Deaconess Medical Center

Description

This session explores the complex, multisystem interactions that drive inflammation in liver disease, with a focus on gut-liver and liver-brain communication. Presentations highlight the roles of the microbiome in estrogen homeostasis, salivary and serum biomarkers in cirrhosis outcomes, and immune signaling pathways such as TLR8 and neutrophil recruitment in biliary and advanced liver disease. The session also delves into how hepatocyte-derived exosomes and β/γ-catenin signaling impact microbiome balance, intestinal inflammation, and neuroinflammation, underscoring new therapeutic opportunities at the interface of immunity and inter-organ communication.

Journey Maps

Presentations

8:30 AM - 8:45 AM
Apr 29 2026
Washington, D.C.

Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort

Jasmohan S. Bajaj, MD, FAASLD , Abstract Presenter
Basic Science
8:45 AM - 9:00 AM
Apr 29 2026
Washington, D.C.

Hepatocyte-derived exosomal miR-122 mediates liver-to-brain crosstalk in alcohol-exposed Alzheimer's disease mice and exacerbates neuroinflammation

Gyongyi Szabo, MD, PhD, FAASLD , Abstract Presenter
Basic Science
9:00 AM - 9:15 AM
Apr 29 2026
Washington, D.C.

Targeting neutrophil recruitment/signaling attenuates biliary disease in a mouse model of Caroli Disease

Romina Fiorotto, PhD , Abstract Presenter
Basic Science

Objectives

  • Describe how gut and salivary microbiomes influence systemic inflammation and clinical outcomes in chronic liver disease.
  • Explain the roles of exosome-mediated signaling and immune cell activation in liver-to-brain and liver-to-gut communication.
  • Evaluate emerging anti-inflammatory targetsincluding TLR8, neutrophil pathways, and /-catenin signalingfor their potential to modulate disease progression across organ systems.