Small Molecules, Big Consequences: Mechanisms of Hepatoxicity

Nov 09 2025
Convention Center: Ballroom C, Level 3
11:00 AM - 12:30 PM

World Class Speakers

Raul J. Andrade, MD, PhD, FAASLD
Abstract Presenter

Raul J. Andrade, MD, PhD, FAASLD

UNIVERSIDAD DE MÁLAGA
Dina Halegoua-DeMarzio, MD
Abstract Presenter

Dina Halegoua-DeMarzio, MD

Thomas Jefferson University Hospital
Paul H Hayashi, MD, MPH, FAASLD
Abstract Presenter

Paul H Hayashi, MD, MPH, FAASLD

FDA
Dina Halegoua-DeMarzio, MD
Moderator

Dina Halegoua-DeMarzio, MD

Thomas Jefferson University Hospital
Paul H Hayashi, MD, MPH, FAASLD
Moderator

Paul H Hayashi, MD, MPH, FAASLD

FDA

Description

This session highlights novel basic science research investigating mechanisms of hepatoxicity. This session spans liver injury and repair for a variety of disease models including acetaminophen-induced liver injury, ethanol hepatoxicity, induction of tumorgenesis and HCC, and the role of coagulation in severe acute liver injury. 

Journey Maps

Presentations

11:00 AM - 11:15 AM
Aug 06 2026
Convention Center - Ballroom C, Level 3

Acute Ethanol-Induced Mitochondrial Depolarization (mtDepo) Enhances Oxygen Consumption and Triggers Pericentral Mitophagy in Mouse Hepatocytes

Dina Halegoua-DeMarzio, MD , Abstract Presenter
Drug-Induced Liver Injury
11:15 AM - 11:30 AM
Aug 06 2026
Convention Center - Ballroom C, Level 3

The novel non-anticoagulant synthetic heparan sulfate 18-mer reduces hepatic non-parenchymal cell tissue factor induction and inhibits coagulation activation in sterile liver injury 

Paul H Hayashi, MD, MPH, FAASLD , Abstract Presenter
Drug-Induced Liver Injury
11:30 AM - 11:45 AM
Aug 06 2026
Convention Center - Ballroom C, Level 3

Integrin α4β7 promotes repair and regeneration in acetaminophen-induced liver injury by recruiting monocytes and driving their pro-reparative programming.

Raul J. Andrade, MD, PhD, FAASLD , Abstract Presenter
Drug-Induced Liver Injury
11:45 AM - 12:00 PM
Aug 06 2026
Convention Center - Ballroom C, Level 3

High-dimensional cytometry for single-cell immune profiling uncovers immunopathological mechanisms in idiosyncratic drug-induced liver injury (DILI) 

Raul J. Andrade, MD, PhD, FAASLD , Abstract Presenter
Drug-Induced Liver Injury
12:00 PM - 12:15 PM
Aug 06 2026
Convention Center - Ballroom C, Level 3

Lack of Hepatic STEAP4 impairs liver regeneration due to increased lysosomal iron accumulation and dysfunction in acetaminophen-induced liver injury in mice

Dina Halegoua-DeMarzio, MD , Abstract Presenter
Drug-Induced Liver Injury

Objectives

  • Describe key pathways for inflammation and recovery in acetaminophen-induced liver injury.
  • Discuss the interplay of metabolic factors, ammonia production, and development of HCC in pre-clinical models.
  • Outline the interplay of immune cells in drug toxicity and liver recovery.