Small Molecules, Big Consequences: Mechanisms of Hepatoxicity

Nov 09 2025
Convention Center: Ballroom C, Level 3
11:00 AM - 12:30 PM

World Class Speakers

Raul J. Andrade, MD, PhD, FAASLD
Abstract Presenter

Raul J. Andrade, MD, PhD, FAASLD

UNIVERSIDAD DE MÁLAGA
Dina Halegoua-DeMarzio, MD
Moderator

Dina Halegoua-DeMarzio, MD

Thomas Jefferson University Hospital
Paul H Hayashi, MD, MPH, FAASLD
Moderator

Paul H Hayashi, MD, MPH, FAASLD

FDA

Description

This session highlights novel basic science research investigating mechanisms of hepatoxicity. This session spans liver injury and repair for a variety of disease models including acetaminophen-induced liver injury, ethanol hepatoxicity, induction of tumorgenesis and HCC, and the role of coagulation in severe acute liver injury. 

Journey Maps

Presentations

11:45 AM - 12:00 PM
Apr 29 2026
Washington, D.C.

High-dimensional cytometry for single-cell immune profiling uncovers immunopathological mechanisms in idiosyncratic drug-induced liver injury (DILI) 

Raul J. Andrade, MD, PhD, FAASLD , Abstract Presenter
Drug-Induced Liver Injury

Objectives

  • Describe key pathways for inflammation and recovery in acetaminophen-induced liver injury.
  • Discuss the interplay of metabolic factors, ammonia production, and development of HCC in pre-clinical models.
  • Outline the interplay of immune cells in drug toxicity and liver recovery.