In this case-based program, presenters provide updates on key topics in general hepatology including: (1) steatotic liver disease, with emphasis on the treatment of MASH and considerations surrounding diagnosis and management of MetALD; (2) hepatitis B management based on the AASLD 2025 guidelines; and (3) primary sclerosing cholangitis, particularly addressing screening, use of pharmacotherapy, and drug development. Cases are used to give clinicians a real-world approach to management of these common liver diseases.