Bioengineered Liver Support, Novel Therapeutics, and Predictive Modeling in Acute Liver Failure

Description

This abstract session presents recent advances in the understanding and management of acute liver failure and acute-on-chronic liver failure. Topics include extracorporeal and bioengineered liver support devices, plasma exchange practices, novel molecular and cellular therapies, and the application of data-driven methods to guide treatment and predict outcomes.

Presentations

8:00 AM - 8:15 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Human Liver Stem Cell-derived Exosomal miR-4492 Protects from Acute Liver Failure by Inhibiting IQGAP1-mediated Disulfidptosis

Qi Yang | Abstract Presenter
8:15 AM - 8:30 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Does Continuous Renal Replacement Therapy Improve Survival in Acute Liver Failure and Acute-on-Chronic Liver Failure: A Time-Varying Analysis of 8,734 ICU Patients 

Mohamed Nadeem, MD | Abstract Presenter
8:30 AM - 8:45 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Development of a Volumetric 3D-Bioprinted Vascularized Artificial Liver for Transplantable Support in Liver Failure

Liwei Du | Abstract Presenter
8:45 AM - 9:00 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Wide Practice Variation in Plasma Exchange for Acute Liver Failure Highlights Need for Evidence-Based Guidance

Paige E Hammis, MD | Abstract Presenter
9:00 AM - 9:15 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

ISRIB as a promising savior for acute liver failure: modulating the gut microbiota-tryptophan metabolism-immune axis

Qi Jiang | Abstract Presenter
9:15 AM - 9:30 AM
Convention Center - Mile High Ballroom 2A-3A
Recorded session

Machine learning model accurately predicts spontaneous survival of phosphorus related hepatotoxicity patients treated with plasma exchange.

Ashish Goel, MD, DM, Ph.D | Abstract Presenter

Objectives

  • Describe current approaches to extracorporeal and bioengineered liver support, including early-phase clinical trial results and 3D-bioprinted liver constructs
  • Identify emerging therapeutic targets in acute liver failure, including ADAMTS13, exosomal miRNA pathways, and gut microbiotaimmune axis modulation
  • Discuss the role of data-driven tools, including time-varying survival analyses and machine learning models, in optimizing treatment decisions and prognostication in liver failure