Hepatobiliary Neoplasia 3: Response or Resistance to Therapy

Description

This session examines mechanisms of treatment resistance in hepatobiliary cancers, including tumor microenvironment and immune evasion pathways driving resistance to immunotherapy.

Presentations

5:00 PM - 5:15 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

Donor HBV exposure status is associated with increased recurrence of hepatocellular carcinoma after liver transplantation: a national registry analysis with propensity-score and weighting-based competing-risks models

Leandro Sierra, MD, | Abstract Presenter
5:15 PM - 5:30 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

Biliary loss of primary cilia and Pten drive intrahepatic cholangiocarcinoma resembling a human subtype with a poor prognosis

Geoffrey g McCaughan, MD, PhD | Abstract Presenter
5:30 PM - 5:45 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

AARS2-Mediated Lactylation Drives CCR4⁺ Treg Recruitment and Immunotherapy Resistance in Hepatocellular Carcinoma

Chunyao Fang, PhD | Abstract Presenter
5:45 PM - 6:00 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

Lipid-Associated SPP1⁺Macrophages Drive Attenuated Responses to Immune Checkpoint Inhibitors in MASLD-Associated Hepatocellular Carcinoma 

Enrui Xie, MD | Abstract Presenter
6:00 PM - 6:15 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

Integrating bulk, single-cell, and spatial transcriptomics reveals potential biomarkers of tertiary lymphoid structure-related genes in prognosis and immunotherapy response in hepatocellular carcinoma

Yuexi Yu | Abstract Presenter
6:15 PM - 6:30 PM
Convention Center - Bluebird Ballroom 1C
Recorded session

ZDHHC4+ CAFs establish an immunosuppressive CMxT niche in hepatocellular carcinoma

Suiqing Zhou, PhD | Abstract Presenter

Objectives

  • Recognize the role of the pericelluar milieu in determining therapeutic susceptibility in hepato-biliary cancers
  • Explore the cellular and subcellular basis for resistance to immunotherapy in hepatocellular carcinoma (HCC)
  • Discuss the ways in which cellular and subcellular factors influence prognosis in intrahepatic cholangiocarcinoma