MTE #14: Emerging Approaches to Managing Complex Cases of Cholestatic and Autoimmune Liver Disease in Pregnancy (Ticketed)

Expert facutly review important considerations and updates regarding the management of primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), intrahepatic cholestasis of pregnancy (ICP), and autoimmune hepatitis (AIH) in pregnancy through case-based discussion. The PBC case highlights the approach to preconception counseling of an individual on second-line PBC therapy. The ICP case highlights the association of chronic liver disease with ICP, the relevance of genetic testing, and approaches to management from ursodiol to novel secondary treatments including rifampicin and ileal bile acid transporter (IBAT) inhibitors. The AIH case focuses on key considerations across preconception, pregnancy, and postpartum periods including risk stratification, medication safety, and strategies to optimize maternal and fetal outcomes.