Our Livers in a Polluted Environment: Mechanisms and Clinical Implications

Expert clinicians and basic scientists come together to explore emerging insights into how environmental chemicals contribute to liver disease pathogenesis. Through a series of complementary presentations, presenters highlight mechanistic and clinical evidence linking exposures—such as polychlorinated biphenyls (PCBs), per‑ and poly‑fluoroalkyl substances (PFAs), vinyl chloride, and other high‑priority environmental toxicants—to hepatotoxicity, inflammatory signaling, metabolic dysfunction, and fibrosis. Speakers integrate cutting‑edge experimental data with clinical observations to illustrate how environmental risk factors shape susceptibility to both acute and chronic liver disease. By spanning molecular pathways, population‑level exposures, and implications for patient care, this program provides a comprehensive and forward‑looking view of the evolving intersection between environmental health and hepatology. This session brings the full weight of both clinical and basic science experts in this area, and incorporates interests at the intersection of toxicology and hepatology.