Transforming Pediatric Cholestatic Liver Disease: New Insights into Biliary Atresia and Genetic Cholangiopathies

Description

This session presents genetic and mechanistic insights into biliary atresia and pediatric cholangiopathies, alongside emerging therapies and outcomes following Kasai portoenterostomy.

Presentations

2:00 PM - 2:15 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

A phase 2-ready ASK1 inhibitor suppresses post-obstructive cholestatic inflammation and fibrosis in experimental biliary atresia

Pranavkumar Shivakumar, MPharm, PhD (Tech.), FAASLD | Abstract Presenter
2:15 PM - 2:30 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

Fibronectin–integrin α5β1 crosstalk is a therapeutic epithelial–immune axis in biliary atresia

Wenqi Li, MB | Abstract Presenter
2:30 PM - 2:45 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

ADJUVANT GRANULOCYTE COLONY-STIMULATING FACTOR AFTER KASAI PORTOENTEROSTOMY FOR BILIARY ATRESIA: A PHASE 2 RANDOMIZED CONTROLLED TRIAL

Anh - Hoa Pham Nguyen, MD | Abstract Presenter
2:45 PM - 3:00 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

Early Timepoints are Critical in Biliary Atresia: Results from Prospectively Following 831 Infants Receiving the Kasai Portoenterostomy 

Sanjiv Harpavat, MD, PhD | Abstract Presenter
3:00 PM - 3:15 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

Genotypic Spectrum and Clinical Outcomes of Genetic Liver Diseases across Asia-Pacific Countries: The ANGELD Study

Huey-Ling Chen, MD, PhD, FAASLD | Abstract Presenter
3:15 PM - 3:30 PM
Convention Center - Bluebird Ballroom 2ABC
Recorded session

Genetic analyses of 1,732 biliary atresia cases identify novel etiologic risk genes in developmental, ciliary, and cholestatic injury pathways

Ronnie Y Li, PhD, | Abstract Presenter

Objectives

  • Describe emerging genetic and molecular mechanisms contributing to biliary atresia and other pediatric cholestatic liver diseases
  • Evaluate novel biomarkers and diagnostic approaches for early disease detection and risk stratification
  • Discuss recent clinical trial outcomes and therapeutic advances for biliary atresia and Alagille syndrome
  • Assess the translational potential of gene-based, RNA-targeted, and pathway-specific therapies in pediatric hepatology