From Uncertainty to Accuracy: Optimizing Outcomes in Adult Genetic Cholestatic Liver Diseases

Nov 08 2026
Convention Center: Four Seasons Ballroom 2-3
12:30 PM - 2:00 PM
CE Credits CE Credits

Description

Progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome (ALGS) frequently present diagnostic challenges in adult clinical practice due to variable phenotypes, delayed recognition, and overlapping hepatic and extrahepatic manifestations. Key focus areas include diagnostic evaluation strategies to recognize previously undiagnosed or later-presenting disease in adults, characterization of hepatic and extrahepatic complications, and implementation of coordinated interprofessional care models. Additionally, evidence-based approaches for selecting targeted management strategies address bile acid accumulation, severe pruritus, and long-term hepatic outcomes. Interactive case-based analysis illustrates essential decision points to optimize clinical recognition, disease monitoring, and overall patient management.

Objectives

  • Evaluate and diagnose adult patients with suspected PFIC or ALGS.
  • Characterize the multisystemic nature of PFIC and ALGS and the need for coordinated interprofessional care.
  • Develop strategies for the appropriate use of targeted therapies in adult genetic cholestatic liver disease.
  • Build effective interprofessional care models for adult patients with PFIC and ALGS.