New Frontiers in Acute-on-Chronic Liver Failure: Bridging Gaps and Pioneering Solutions

Nov 08 2025
Convention Center: Ballroom B, Level 3
2:00 PM - 3:30 PM

World Class Speakers

Jacqueline O'Leary, MD MPH
Presenter

Jacqueline O'Leary, MD MPH

UTSW
Ruben Hernaez, MD, MPH, PhD
Presenter

Ruben Hernaez, MD, MPH, PhD

Baylor College of Medicine
Jasmohan S. Bajaj, MD, FAASLD
Presenter

Jasmohan S. Bajaj, MD, FAASLD

Virginia Commonwealth University
Juan G Abraldes, MD
Presenter

Juan G Abraldes, MD

University of Alberta
Rakhi Maiwall, MD, DM
Moderator

Rakhi Maiwall, MD, DM

Institute of Liver and Biliary Sciences

Description

The Acute-on-Chronic Liver Failure (ACLF) Special Interest Group presents current clinical and research gaps pertaining to the study and care of patients with ACLF. The introductory presentation prompts further discussion on 4 distinct topics focused on: (1) outstanding care gaps in critically ill patients with ACLF; (2) the role of novel statistical methods in ACLF diagnosis and prognostication; (3) designing clinical studies in ACLF; and (4) pathways to therapeutic advancements in ACLF. The session concludes with a panel discussion.

 

Journey Maps

Presentations

2:00 PM - 2:15 PM
Nov 08 2025
San Diego, CA

Introduction to the Session: Integrating Clinical Concepts in Acute-on-Chronic Liver Failure Study Design

Jacqueline O'Leary, MD MPH, Presenter
Acute-on-Chronic Liver Failure
2:15 PM - 2:30 PM
Nov 08 2025
San Diego, CA

Outstanding Care Gaps in Critically Ill Patients With Acute-on-Chronic Liver Failure

Constantine J Karvellas, MD, SM, FRCPC, FCCM, Presenter
Acute-on-Chronic Liver Failure
2:30 PM - 2:45 PM
Nov 08 2025
San Diego, CA

Novel Statistical Approaches in Acute-on-Chronic Liver Failure Diagnosis and Prognosis

Juan G Abraldes, MD, Presenter
Acute-on-Chronic Liver Failure
2:45 PM - 3:00 PM
Nov 08 2025
San Diego, CA

Designing Clinical Studies in Acute-on-Chronic Liver Failure: Unifying Clinical Components

Ruben Hernaez, MD, MPH, PhD, Presenter
Acute-on-Chronic Liver Failure
3:15 PM - 3:30 PM
Nov 08 2025
San Diego, CA

Emerging Therapeutics for Acute-on-Chronic Liver Failure

Jasmohan S. Bajaj, MD, FAASLD, Presenter
Acute-on-Chronic Liver Failure

Objectives

  • Identify current care gaps in critically ill patients with acute-on-chronic liver failure (ACLF).
  • Assess statistical methods for developing tools to better guide ACLF diagnosis and prognostication.
  • Evaluate universal clinical components of the ACLF syndrome important for designing clinical studies in ACLF.
Chair

Christina C Lindenmeyer, MD

Cleveland Clinic
Chair

Constantine J Karvellas, MD, SM, FRCPC, FCCM

University of Alberta